Dictyostelium Mutants

Phenotypes for Dictyostelium mutants

View other mutant types: All mutant strains - Null - Overexpression - Multiple - Other - Developmental

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Systematic Name Strain Descriptor Associated gene(s) Phenotypes
DBS0350657 [csaA]: csaAcsaAaberrant aggregation | increased calcium-independent cell-cell adhesion
DBS0350826 pinA-pinAdecreased growth rate | decreased mound size | decreased sporulation
DBS02354121C7gp130decreased cell-substrate adhesion | delayed development | increased growth rate
DBS02386015NT-5ntdelayed development of tipped mound | increased number of mound tips | increased number of early culminant tips
DBS0235584CF45-1-cf45-1increased mound size | increased glucose level | decreased mound size | decreased cell motility | increased cell-cell adhesion
DBS0235585CF50-cf50-1decreased response to Gram-negative bacterium | decreased response to Gram-positive bacterium | increased mound size | increased cell-cell adhesion | increased prespore gene expression | increased protein level | decreased protein secretion
DBS0235585CF50-cf50-2decreased response to Gram-negative bacterium | decreased response to Gram-positive bacterium | increased mound size | increased cell-cell adhesion | increased prespore gene expression | increased protein level | decreased protein secretion
DBS0235594CHE10cbpCdecreased slug migration | precocious aggregation | decreased mound size | decreased fruiting body size | delayed culmination
DBS0235595CHI2cbpCincreased slug migration
DBS0235659DD3-3-DD3-3decreased gene expression | precocious aggregation
DG1007DDB_G0269232-DDB_G0269232abolished culmination
DBS0351081DDB_G0272538-DDB_G0272538delayed aggregation | increased cell-substrate adhesion
LAS29DDB_G0273201-DDB_G0273201decreased socially cooperative development
LAS8DDB_G0273809-zplC-1decreased socially cooperative development
LAS8DDB_G0273809-zplC-2decreased socially cooperative development
LAS43DDB_G0274429-DDB_G0274429decreased socially cooperative development
DBS0351079DDB_G0274679-DDB_G0274679delayed aggregation | increased cell-substrate adhesion | decreased cell motility
LAS26DDB_G0277239-DDB_G0277239decreased socially cooperative development
LAS34DDB_G0278585-DDB_G0278585decreased socially cooperative development
LAS70DDB_G0279405-DDB_G0279405decreased socially cooperative development
LAS103DDB_G0280089-DDB_G0280089decreased socially cooperative development
LAS54DDB_G0280299-DDB_G0280299decreased socially cooperative development
DBS0351082DDB_G0281485-DDB_G0281485delayed aggregation | increased cell-substrate adhesion | decreased cell motility
DBS0351080DDB_G0281497-DDB_G0281497delayed aggregation | increased cell-substrate adhesion | decreased cell motility
LAS92DDB_G0283373-DDB_G0283373decreased socially cooperative development
LAS106DDB_G0283595-DDB_G0283595decreased socially cooperative development
DBS0351085DDB_G0284955-DDB_G0284955delayed aggregation | increased cell-substrate adhesion | decreased cell motility
LAS3DDB_G0287153-DDB_G0287153decreased socially cooperative development
LAS10DDB_G0288547-DDB_G0288547decreased socially cooperative development
LAS9DDB_G0289789-DDB_G0289789decreased socially cooperative development
DBS0351086DDB_G0290519-DDB_G0290519delayed aggregation | increased cell-substrate adhesion | decreased cell motility
LAS7DDB_G0290685-DDB_G0290685decreased socially cooperative development
DG1003DDB_G0291992-DDB_G0291992aberrant late culminant morphology
LAS39DDB_G0292148-DDB_G0292148decreased socially cooperative development
DBS0350073DDB_G0293074-DDB_G0293074decreased spore germination | delayed aggregation
DBS0351083DDB_G0293098-DDB_G0293098delayed aggregation | increased cell-substrate adhesion | decreased cell motility
DG1039DG1039-DDB_G0284037aberrant fruiting body morphogenesis
DG1040DG1040-DDB_G0276029aberrant fruiting body morphogenesis
DG1041DG1041-DDB_G0269126aberrant fruiting body morphogenesis
DG1054DG1054-DDB_G0277719aberrant fruiting body morphogenesis
DG1060DG1060-DDB_G0281953aberrant fruiting body morphogenesis
DG1062DG1062-cdl1Aaberrant fruiting body morphogenesis
DG1074DG1074-DDB_G0272108aberrant fruiting body morphogenesis
DG1080DG1080-DDB_G0281559aberrant fruiting body morphogenesis
DG1091DG1091-DG1091decreased fruiting body size
DG1098DG1098-DG1098decreased fruiting body size
DG1104DG1104-DDB_G0283535abolished aggregation
DG1106DG1106-keaAabolished aggregation
DG1110DG1110-DDB_G0269128aberrant fruiting body morphogenesis
DG1112DG1112-DG1112decreased stalk width
DG1113DG1113-DG1113increased stalk length
DG1122DG1122-DG1122aberrant fruiting body morphogenesis
DG1124DG1124-DG1124development arrests at loose mound stage
DG2033DG2033-DG2033development arrests at mound stage
DG2044DG2044-DG2044development arrests at loose mound stage
DBS0266692Dd5P4-Dd5P4increased protein localization | increased protein phosphorylation | increased contractile vacuole size | decreased defense response to Gram-negative bacterium | increased number of mound tips | aberrant contractile vacuole discharge | decreased growth rate | decreased phagocytosis | decreased engulfment during phagocytosis | aberrant endosome morphology | aberrant vacuole organization | decreased protein localization | increased cell motility | increased activation of GTPase activity
DBS0266695Dd5P4-/ [act15]: GAP5P4Dd5P4increased number of mound tips | decreased growth rate
DBS0266694Dd5P4-/ [act15]: cat5P4Dd5P4increased number of mound tips | decreased growth rate
CW0391FLAG-VwkAvwkAincreased myosin II assembly | decreased growth rate | aberrant cytokinesis | development arrests at mound stage | aberrant hypotonic response | increased protein level
DBS0236015GEG04K11 (tmcB- in KAX3)tmcBdecreased macrocyst size | aberrant macrocyst formation
DBS0236017GEG10K23 (tmcC- in KAX3)tmcCaberrant macrocyst formation
DBS0236128HB3H3babolished stream development | abolished response to cAMP
DL118HL216/ HL261gnt2decreased migratory slug size | decreased calcium-independent cell-cell adhesion | decreased fruiting body size
HL220HL220gnt2abolished gene expression | aberrant spore coat morphology | decreased calcium-independent cell-cell adhesion
HMW404HMW404manAabolished gene expression | abolished catalytic activity | abolished aggregation
HTY506HTY506pkaRaberrant spore morphology | precocious sporulation | aberrant fruiting body morphogenesis | decreased actin phosphorylation | precocious development | decreased cAMP level | decreased sporulation
HTY507HTY507rdeAprecocious aggregation | decreased mound size | increased cAMP level | aberrant fruiting body morphogenesis
DBS0236444JH.DcbfAabolished gene expression | aberrant cellular metabolic process | decreased gene expression | increased gene expression | decreased growth rate | increased pinocytosis | increased vegetative cell size | decreased fruiting body size | decreased stalk width | abolished aggregation | increased phagocytosis
DBS0236840R7nosAdevelopment arrests at mound stage
SA31SA31dscA-1abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscA-2abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscC-1abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscC-2abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscD-1abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscD-2abolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
SA31SA31dscEabolished gene expression | abolished stream development | aberrant microtubule cytoskeleton organization | decreased establishment of cell polarity
DBS0264065V00262dagAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264066V00347DDB_G0281917abolished culmination
DBS0264073V10108DDB_G0292162abolished stream development | abolished slug migration | aberrant vegetative growth | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264075V10113yakAabolished stream development | abolished slug migration | aberrant vegetative growth | abolished oscillatory cAMP signaling | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264078V10116tipBaberrant aggregation | abolished slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264079V10117DDB_G0285083aberrant slug migration | abolished culmination
DBS0264087V10125DDB_G0293302aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264088V10126tipCaberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264089V10127DG1037abolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264098V10136DDB_G0293590wild type | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264099V10137yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264106V10144comHaberrant aggregation | abolished slug migration | abolished culmination
DBS0264108V10146yakAabolished stream development | abolished slug migration | aberrant vegetative growth | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264109V10147tipAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264116V10155DDB_G0282093abolished stream development | aberrant aggregation | abolished slug migration | aberrant culmination | aberrant slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264118V10157usp12aberrant culmination | aberrant slug migration | aberrant stream morphology | abolished culmination
DBS0264125V10164comEaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264126V10165comDaberrant aggregation | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264129V10168prsCwild type | aberrant slug migration
DBS0264131V10170DDB_G0283015aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264135V10174DDB_G0288581aberrant vegetative growth | aberrant culmination | aberrant slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264145V10185abcA5wild type | aberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264150V10190yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264151V10191sfbAaberrant culmination | aberrant slug migration | abolished culmination
DBS0264152V10192tipDaberrant aggregation | abolished slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264154V10194modAaberrant culmination | aberrant slug migration
DBS0264155V10195migAaberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264157V10197yelAabolished slug migration | aberrant culmination | aberrant slug migration
DBS0264158V10198splAaberrant aggregation | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264159V10199DG1037abolished slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264160V10200DDB_G0289377aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264161V10201rgaAaberrant vegetative growth | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264163V10203modAwild type | aberrant vegetative growth | aberrant culmination
DBS0264164V10204DG1124aberrant aggregation | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264169V10209dcsAabolished culmination
DBS0264170V10210mkpAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264171V10211migAaberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264172V10212tipCaberrant aggregation | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264173V10213DG1098aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264181V10221tipDaberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264183V10223erkAaberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264185V10225acrAaberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264186V10226ggtAaberrant vegetative growth | aberrant culmination | aberrant slug migration | abolished aggregation | abolished culmination
DBS0264187V10227piaAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264188V10228comGaberrant aggregation | abolished slug migration | aberrant vegetative growth | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264189V10229dcsAaberrant oscillatory cAMP signaling | abolished culmination
DBS0264190V10230ctrAaberrant aggregation | aberrant culmination | aberrant slug migration
DBS0264193V10233piaAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264196V10236DDB_G0270872_psaberrant stream morphology
DBS0264198V10238DDB_G0269128aberrant culmination | aberrant slug migration
DBS0264199V10239kif12wild type | aberrant culmination
DBS0264201V10241lvsBaberrant culmination
DBS0264202V10242tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264204V10244gbfAaberrant culmination | aberrant slug migration
DBS0264205V10245gefAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264206V10246dicBaberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264207V10247yelAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264212V10252tagBaberrant aggregation | abolished slug migration | abolished culmination
DBS0264216V10256DDB_G0293302abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264218V10258rdeAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264220V10260gacTaberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264224V10264DDB_G0282787_RTEaberrant aggregation | wild type | abolished slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264225V10265lvsDaberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264227V10267DDB_G0292260_RTEaberrant aggregation | aberrant stream morphology
DBS0264228V10268dhkAaberrant culmination | aberrant slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264229V10269helCwild type | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264230V10270mekAaberrant vegetative growth | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264231V10271lvsBabolished stream development | abolished slug migration | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264232V10272modAabolished stream development | abolished slug migration | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264234V10274DG1113aberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264235V10275DG1122abolished stream development | wild type | abolished slug migration | aberrant vegetative growth | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264238V10278modAaberrant aggregation | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264240V10280mekAaberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264241V10281DDB_G0268266aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264242V10282phdAabolished slug migration | aberrant culmination | aberrant stream morphology
DBS0264245V10285scaAabolished stream development | abolished slug migration | aberrant vegetative growth | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264246V10286amdAwild type | aberrant culmination
DBS0264247V10287helCwild type | aberrant culmination | aberrant slug migration
DBS0264251V10300DDB_G0278333aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264269V10322roco5aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264281V10356DDB_G0275747aberrant slug migration
DBS0264284V10367DDB_G0282463aberrant vegetative growth | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264287V10431kcnma1wild type | aberrant culmination | aberrant slug migration
DBS0264290V10435gefLabolished slug migration | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264297V10445DDB_G0290835aberrant slug migration
DBS0264303V10460abcC9aberrant slug migration
DBS0264316V10483yod1aberrant aggregation | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264318V10490gefVaberrant culmination | aberrant oscillatory cAMP signaling
DBS0264319V10492med23aberrant culmination | aberrant oscillatory cAMP signaling
DBS0264320V10495DDB_G0269128wild type | aberrant culmination | aberrant slug migration
DBS0264324V10514adprt3aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264330V10529cyp508B1aberrant aggregation | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264331V10530DDB_G0270344wild type | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264334V10534DDB_G0291812wild type | aberrant culmination
DBS0264335V10535DDB_G0277165aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264337V10537gbpCabolished stream development | wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264347V10567dagAabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264349V10570DDB_G0281115wild type | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0264356V10588dhkCwild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264373V10633gtaGabolished slug migration | aberrant culmination | aberrant slug migration | abolished culmination
DBS0264390V10682clcDabolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264425V11033nfaAaberrant aggregation | wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264432V11040DDB_G0274177abolished stream development | abolished slug migration | abolished oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0264446V11055ku80aberrant vegetative growth | aberrant culmination
DBS0264464V11075cinCwild type | aberrant culmination
DBS0264489V11105DDB_G0270350_pswild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264512V11128DDB_G0278945aberrant vegetative growth | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264575V30069DDB_G0284619aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264630V30133DDB_G0272953wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264662V30165alg9wild type | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264668V30171DDB_G0285261wild type | aberrant vegetative growth | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264677V30180gpaFwild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264684V30188DDB_G0287723wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264700V30213act9wild type | aberrant culmination
DBS0264716V30230regAaberrant aggregation | abolished slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished culmination
DBS0264731V30245DDB_G0279461wild type | aberrant culmination
DBS0264773V30288DDB_G0293300wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264823V30341frmBwild type | aberrant culmination | aberrant stream morphology
DBS0264853V30371abpCaberrant aggregation | abolished slug migration | aberrant culmination | abolished culmination
DBS0264905V30427DDB_G0291926aberrant culmination | aberrant slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264992V30522DDB_G0288007wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0264994V30524prmt5aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0265002V30532lvsAwild type | abolished slug migration | aberrant oscillatory cAMP signaling | abolished aggregation | abolished culmination
DBS0265017V30547DDB_G0279105wild type | aberrant vegetative growth | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265029V30561DDB_G0277355wild type | aberrant culmination
DBS0265045V30578DDB_G0277165aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0265064V30604DDB_G0279461abolished slug migration | aberrant culmination | aberrant slug migration | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265099V30642tipCaberrant aggregation | abolished slug migration | aberrant oscillatory cAMP signaling | abolished culmination
DBS0265126V30673dicBaberrant aggregation | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0265140V30688DDB_G0279727wild type | aberrant culmination
DBS0265309V30876DDB_G0268248wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265311V30879exoc2wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265348V30921snpCwild type | aberrant culmination
DBS0265466V31043DDB_G0275917aberrant aggregation | wild type | aberrant vegetative growth | aberrant slug migration | abolished culmination
DBS0265497V31075DDB_G0282985wild type | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling | abolished aggregation
DBS0265529V31111vps13Ewild type | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265567V31151DDB_G0275539wild type | aberrant vegetative growth | abolished culmination
DBS0265588V31173ggtAaberrant vegetative growth | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265662V31255psiNwild type | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265688V31281DDB_G0286417wild type | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0265873V31480DDB_G0284177aberrant culmination
DBS0265890V31501DDB_G0282985wild type | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0265908V31523tmem184Cwild type | aberrant culmination
DBS0265911V31528DDB_G0279945aberrant culmination
DBS0265938V31568rsc12aberrant culmination
DBS0266000V31649DDB_G0290383wild type | aberrant culmination
DBS0266022V31671dhkAaberrant culmination | aberrant slug migration
DBS0266036V31685tipCaberrant aggregation | wild type | abolished slug migration | aberrant culmination | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0266084V31738dcsAwild type | aberrant culmination | abolished culmination
DBS0266088V31742dstAaberrant culmination | aberrant slug migration | abolished culmination
DBS0266089V31743DDB_G0273459aberrant aggregation | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0266153V31811gpt1wild type | aberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0266190V31853chlAaberrant aggregation | aberrant culmination | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0266195V31858DDB_G0286341wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0266246V31916psiFwild type | aberrant vegetative growth | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0266249V31919DDB_G0276251aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0266253V31923DDB_G0268314wild type | aberrant culmination
DBS0266271V31941manAaberrant aggregation | aberrant culmination | aberrant stream morphology | aberrant slug migration | aberrant oscillatory cAMP signaling
DBS0266299V31970DDB_G0280581wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0266309V31982DDB_G0286341abolished stream development | wild type | aberrant stream morphology | aberrant oscillatory cAMP signaling
DBS0266316V31989DDB_G0270342abolished stream development | wild type | abolished slug migration | aberrant culmination | aberrant oscillatory cAMP signaling
DBS0237236[AS]: [tet]: trrAtrrAdecreased growth rate | delayed development | abolished aggregation
DBS0350570[AS]PARPDDB_G0286613decreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPDDB_G0289141decreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPadprt1Adecreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPadprt1Bdecreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPadprt2decreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPadprt3decreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPadprt4decreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPpARTfdecreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350570[AS]PARPpARTgdecreased cell death | aberrant positive regulation of mitochondrial membrane potential
DBS0350559[AS]act15: adprt1Aadprt1Adevelopment arrests at loose mound stage | decreased gene expression | decreased ATP level | increased mitochondrial fission
DBS0351092[AS]aifaifaberrant cellular homeostasis | aberrant regulation of mitochondrial membrane potential | aberrant mitochondrion morphology | decreased ATP level | increased gene expression | decreased gene expression | decreased growth rate | aberrant cell cycle | increased necrotic cell death | delayed development | aberrant response to oxidative stress | aberrant cell morphology | increased mitochondrial fission | aberrant mitochondrion organization
DBS0350897[AS]carAcarA-1abolished aggregation
DBS0350897[AS]carAcarA-2abolished aggregation
DBS0237222[AS]cf60cf60increased mound size | decreased number of mounds
DBS0237228[AS]cfrA/ [AS]cfrBcfrAdecreased sexual fusion
DBS0237228[AS]cfrA/ [AS]cfrBcfrBdecreased sexual fusion
DBS0237223[AS]chcAchcAdecreased pinocytosis | delayed hypotonic response | decreased number of vacuoles | decreased vegetative cell size | aberrant vacuole organization | abolished aggregation
DBS0237224[AS]cmfAcmfAabolished aggregation
DBS0237225[AS]cupBcupBabolished aggregation
DBS0350979[AS]deeJdeeJdecreased pinocytosis | decreased phagocytosis | aberrant fruiting body morphogenesis
DBS0237226[AS]dia1dia1decreased gene expression | precocious aggregation
DBS0351176[AS]dscAdscA-1abolished stream development
DBS0351176[AS]dscAdscA-2abolished stream development
DBS0350560[AS]ecmB: adprt1Aadprt1Adevelopment arrests at slug stage
DBS0351057[AS]gshBgshBincreased slug migration
HPF414[AS]hspAhspAdecreased growth rate | aberrant fruiting body morphogenesis | decreased defense response to bacterium
DBS0351171[AS]htrAhtrAdecreased growth rate | aberrant fruiting body morphogenesis
DBS0304425[AS]mppA1mppA1delayed development
DBS0237504[AS]pikEpikEaberrant stalk morphogenesis | decreased growth rate
DBS0237231[AS]ppiAppiAincreased stalk length
DBS0350355[AS]proA-/ proB-/ lmpA-lmpAabolished sporulation | wild type
DBS0350355[AS]proA-/ proB-/ lmpA-proAabolished sporulation | wild type
DBS0350355[AS]proA-/ proB-/ lmpA-proBabolished sporulation | wild type
DBS0236827[AS]proA/ proB-proAdecreased exocytosis | decreased pinocytosis | aberrant exocytosis | increased actin filament polymerization | development arrests at slug stage | aberrant cytokinesis | decreased cell motility | abolished vegetative growth | decreased secretion of lysosomal enzymes | increased phagocytosis
DBS0236827[AS]proA/ proB-proBdecreased exocytosis | decreased pinocytosis | aberrant exocytosis | increased actin filament polymerization | development arrests at slug stage | aberrant cytokinesis | decreased cell motility | abolished vegetative growth | decreased secretion of lysosomal enzymes | increased phagocytosis
DBS0350574[AS]rps4rps4decreased spore germination | aberrant actin cytoskeleton organization | aberrant vegetative growth | decreased mound size | decreased spore size | aberrant fruiting body morphogenesis | decreased sporulation
DBS0236904[AS]rps4mrps4delayed aggregation | aberrant fruiting body morphogenesis
DBS0237234[AS]smlAsmlAdecreased fruiting body size
DBS0238748[AS]snfAsnfAdecreased number of mitochondria | decreased ATP level | increased growth rate | decreased fruiting body size | aberrant mitochondrion organization
DBS0304498[AS]sslA1sslA1decreased fruiting body size
DBS0237235[AS]tcp1tcp1decreased growth rate | development arrests at mound stage | aberrant fruiting body morphogenesis
DBS0350649[AS]vatBvatBdelayed aggregation | aberrant slug migration | aberrant response to chemical
DBS0306102[AS]vatPvatPdecreased calcium ion import | decreased growth rate | delayed development
DBS0237276[OE]: GFP: gxcAgxcAabolished aggregation
DBS0350519[OE]: egeAegeAdecreased protein level | abolished aggregation
JH182[OE]: gpaDgpaDaberrant fruiting body morphogenesis | decreased sporulation
JH258[OE]: gpaEgpaEprecocious prestalk gene expression | precocious prespore gene expression | precocious development of tipped mound
DBS0236962[OE]: pdiApdiAdelayed aggregation
DBS0237015[OE]: pdiApdiAaberrant development of tipped mound | abolished culmination | abolished slug development
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-gcAincreased lateral pseudopodium formation | aberrant chemotaxis to cAMP | aberrant stream morphology | decreased chemotaxis rate
DBS0302682[OE]: sgcA(N1106A): GFP/ gca-/ sgcA-sgcAincreased lateral pseudopodium formation | aberrant chemotaxis to cAMP | aberrant stream morphology | decreased chemotaxis rate
DBS0237284[OE]GFP: gxcA(1-750: 764-1217)gxcAdevelopment arrests at loose mound stage
DBS0237285[OE]GFP: gxcA(1-750: 764-984)gxcAdevelopment arrests at loose mound stage
DBS0350172[RNAi]allCallCdevelopment arrests at loose mound stage | decreased protein level | decreased gene expression | decreased vegetative cell size | increased growth rate
DBS0350070[RNAi]canAcanAaberrant sorus morphology | aberrant response to cation stress | increased defense response to Gram-negative bacterium | decreased fruiting body size | decreased stalk length
DBS0235409[RNAi]cnbAcnbAaberrant sorus morphology | decreased gene expression | aberrant response to cation stress | increased defense response to Gram-negative bacterium | aberrant stalk cell differentiation | decreased stalk length
DBS0349787[RNAi]ctnnActnnAabolished epithelium-like organization | abolished stalk development | aberrant protein secretion | abolished establishment of cell polarity | aberrant Golgi localization | aberrant centrosome localization | abolished culmination | aberrant protein localization
DBS0349923[RNAi]ctnnA/ [act15]: GFP-mhcActnnAaberrant stalk morphogenesis | decreased epithelium-like organization | aberrant protein localization
DBS0349944[RNAi]fttBfttBincreased number of mound tips | aberrant cytokinesis | decreased growth rate | delayed development | decreased chemotaxis to cAMP | aberrant cytoskeleton organization
DBS0237308[RNAi]gmsAgmsAdecreased sexual fusion
DBS0237309[RNAi]gsrgsrprecocious culmination | decreased cell migration to prestalk region | precocious gene expression
DBS0349871[RNAi]lkb1lkb1abolished prespore cell differentiation | delayed aggregation | aberrant slug development | aberrant sorocarp development | aberrant response to osmotic stress | aberrant response to oxidative stress | aberrant regulation of protein kinase activity | increased prestalk cell differentiation | decreased sporulation
DBS0350643[RNAi]nse1nse1aberrant response to UV | aberrant stream morphology | decreased fruiting body size
DBS0350644[RNAi]nse4nse4decreased gene expression | aberrant response to UV | aberrant stream morphology | decreased fruiting body size
DBS0238734[RNAi]sdhAsdhAabolished aggregation | decreased phototaxis
DBS0351295[RNAi]sir2Dsir2Ddecreased gene expression | delayed development
DBS0349929[RNAi]tacAtacAaberrant response to cation stress | increased gene expression | delayed development | aberrant fruiting body morphogenesis
DBS0237313[RNAi]tmcBtmcBaberrant macrocyst formation
DBS0237314[RNAi]tmcCtmcCaberrant macrocyst formation
DBS0237315[RNAi]trap1trap1decreased gene expression | delayed development
DBS0351202[act15]: 6xHis: amd1: eYFPamd1decreased gene expression | increased gene expression | aberrant vegetative growth | aberrant fruiting body morphogenesis | delayed development | mitotic G1 phase arrest
DBS0351167[act15]: 6xHis: ei24: eYFPei24aberrant aggregation | increased chemotaxis to cAMP | aberrant cell cycle | increased cAMP level | increased sporulation
DBS0350674[act15]: 6xHis: erkAerkAaberrant slug development
DBS0351253[act15]: 6xHis: sesn: eYFPsesnaberrant aggregation | decreased protein level | increased gene expression | decreased growth rate | aberrant response to oxidative stress
DBS0350049[act15]: FLAG: cycCcycCprecocious development of tipped mound
DBS0350321[act15]: FLAG: hbx4hbx4aberrant aggregation | abolished gene expression | abolished slug migration | decreased growth rate | aberrant cytokinesis
DBS0350325[act15]: FLAG: hbx4/ [ecmAO]: lacZhbx4decreased spore germination | increased prestalk gene expression | abolished prespore gene expression | increased prestalk cell differentiation
DBS0351294[act15]: FLAG: mybBmybBincreased gene expression | precocious development
DBS0238108[act15]: FLAG: ppp4C(H113Q)ppp4cdevelopment arrests at mound stage | delayed development
DBS0351292[act15]: FLAG: sir2Asir2Adelayed development
DBS0351293[act15]: FLAG: sir2Csir2Cdelayed development
DBS0351291[act15]: FLAG: sir2Dsir2Dincreased gene expression | precocious development
DBS0351097[act15]: GFP: cbpGcbpGincreased cell-substrate adhesion | increased vegetative cell size | decreased chemotaxis to cAMP | abolished aggregation
DBS0350594[act15]: GFP: cepL(1-1114)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350595[act15]: GFP: cepL(1-763)cepLincreased number of centrosomes | decreased growth rate | aberrant vegetative growth | increased fruiting body size | decreased phagocytosis | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant phototaxis
DBS0350596[act15]: GFP: cepL(763-1114)cepLdevelopment arrests at loose mound stage | abolished establishment of cell polarity | delayed aggregation | decreased vegetative cell size | increased cell-substrate adhesion | decreased chemotaxis rate | increased growth rate | aberrant phototaxis | delayed gene expression
DBS0350984[act15]: GFP: frmBfrmBdecreased spore size | aberrant stalk development
DBS0350422[act15]: GFP: gpbBgpbBaberrant vegetative growth | delayed development
DBS0237117[act15]: GFP: krsAkrsAdecreased slug migration
DBS0350852[act15]: GFP: nkaPnkaPaberrant aggregation | decreased gene expression | increased gene expression | aberrant vegetative growth | increased chemotaxis rate
DBS0235442[act15]: GFP: pldBpldBabolished aggregation
DBS0351073[act15]: GFP: rac1A(G12V)rac1Adecreased growth rate | decreased phagocytosis | aberrant cytokinesis | decreased macropinocytosis | decreased cell motility | delayed development | aberrant actin filament organization | abolished filopodium formation
DBS0351074[act15]: GFP: rac1C(G12V)rac1Cdecreased growth rate | decreased phagocytosis | aberrant cytokinesis | decreased macropinocytosis | decreased cell motility | delayed development | aberrant actin filament organization | abolished filopodium formation
DBS0238111[act15]: HA: smkAsmkAdelayed development | decreased fruiting body size | decreased establishment of cell polarity | decreased chemotaxis to cAMP
DBS0350429[act15]: RFP: abpEabpE-1delayed aggregation
DBS0350429[act15]: RFP: abpEabpE-2delayed aggregation
DBS0237227[act15]: [AS]dia2dia2aberrant extracellular cAMP signaling pathway | abolished aggregation | decreased cAMP level
DBS0237096[act15]: abpEabpE-1aberrant aggregation | increased lateral pseudopodium formation | decreased cell motility | delayed development | decreased fruiting body size
DBS0237096[act15]: abpEabpE-2aberrant aggregation | increased lateral pseudopodium formation | decreased cell motility | delayed development | decreased fruiting body size
DBS0349940[act15]: acrA(1-731): YFPacrAaberrant spore coat morphology | decreased adenylate cyclase activity
DBS0350800[act15]: adprt1Aadprt1Aincreased gene expression | decreased gene expression | decreased ATP level | delayed aggregation | aberrant cell cycle | decreased growth rate | aberrant response to oxidative stress | increased mitochondrial fission | decreased cAMP level
DBS0238088[act15]: atg1(K36A)atg1abolished macroautophagy | increased number of autophagosomes | aberrant cellular response to nitrogen starvation | abolished aggregation
JK1[act15]: carAcarA-1delayed aggregation
JK1[act15]: carAcarA-2delayed aggregation
DBS0252740[act15]: carA(I104D)carA-1increased cAMP binding | delayed aggregation | aberrant oscillatory cAMP signaling | decreased protein kinase activation
DBS0252740[act15]: carA(I104D)carA-2increased cAMP binding | delayed aggregation | aberrant oscillatory cAMP signaling | decreased protein kinase activation
DBS0252744[act15]: carA(I104E)carA-1increased cAMP binding | delayed aggregation | aberrant oscillatory cAMP signaling
DBS0252744[act15]: carA(I104E)carA-2increased cAMP binding | delayed aggregation | aberrant oscillatory cAMP signaling
DBS0252747[act15]: carA(I104H)carA-1development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252747[act15]: carA(I104H)carA-2development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252749[act15]: carA(I104K)carA-1increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation | abolished aggregation
DBS0252749[act15]: carA(I104K)carA-2increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation | abolished aggregation
DBS0252746[act15]: carA(I104N)carA-1development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252746[act15]: carA(I104N)carA-2development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252745[act15]: carA(I104Q)carA-1development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252745[act15]: carA(I104Q)carA-2development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252750[act15]: carA(I104R)carA-1development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252750[act15]: carA(I104R)carA-2development arrests at loose mound stage | increased cAMP binding | abolished oscillatory cAMP signaling | decreased protein kinase activation
DBS0252748[act15]: carA(I104Y)carA-1development arrests at loose mound stage | increased cAMP binding | aberrant oscillatory cAMP signaling | decreased protein kinase activation
DBS0252748[act15]: carA(I104Y)carA-2development arrests at loose mound stage | increased cAMP binding | aberrant oscillatory cAMP signaling | decreased protein kinase activation
DBS0351055[act15]: catAcatAdecreased slug migration | decreased fruiting body size | decreased superoxide generation | decreased sporulation
DBS0237098[act15]: cdk5(D144N)cdk5decreased pinocytosis | increased mound size | aberrant protein level | delayed aggregation | decreased phagocytosis | decreased growth rate | decreased sporulation | decreased protein secretion
DBS0237099[act15]: cf60cf60increased number of mounds | aberrant mound size
DBS0302445[act15]: cfaDcfaDdecreased growth rate | aberrant fruiting body morphogenesis
DBS0302658[act15]: cnrN: myc/ smlA-cnrNdecreased fruiting body size
DBS0302658[act15]: cnrN: myc/ smlA-smlAdecreased fruiting body size
DBS0350583[act15]: csaAcsaAdecreased cell-substrate adhesion | precocious aggregation | increased calcium-independent cell-cell adhesion
DBS0350642[act15]: cynA: GFPcynAaberrant cell motility | precocious aggregation | aberrant establishment or maintenance of cell polarity
DBS0237105[act15]: dgkAdgkAdevelopment arrests at loose mound stage | decreased chemotaxis rate | decreased myosin II assembly
DBS0237106[act15]: dhkC(394-661)dhkCdevelopment arrests at slug stage | increased slug migration
DBS0235716[act15]: dhkKdhkKprecocious aggregation | development arrests at mound stage
DBS0235705[act15]: dhkK(D1125N)dhkKaberrant extracellular cAMP signaling pathway | delayed development
DBS0235707[act15]: dhkK(H825Q)dhkKprecocious development | decreased fruiting body size
DBS0235709[act15]: dhkK(H825Q/ D1125N)dhkKaberrant slug migration | delayed culmination
DBS0237107[act15]: dng1dng1aberrant extracellular cAMP signaling pathway | decreased growth rate | precocious aggregation
DBS0350396[act15]: eif2s1(S53A)eif2s1aberrant spore morphology | decreased spore germination | decreased protein level
DBS0237108[act15]: fbxA: FLAGfbxAdecreased prespore cell differentiation
DBS0350365[act15]: fip(1163-2038)fip-1aberrant prestalk O cell differentiation
DBS0350365[act15]: fip(1163-2038)fip-2aberrant prestalk O cell differentiation
DBS0237601[act15]: gbpDgbpDaberrant aggregation | decreased cell-cell adhesion | increased guanyl-nucleotide exchange factor activity | increased cell-substrate adhesion | decreased chemotaxis to cAMP | aberrant cell morphology | increased pseudopodium formation
DBS0351056[act15]: gcsAgcsAincreased catalytic activity | decreased slug migration | aberrant gene expression | decreased fruiting body size | decreased superoxide generation | decreased sporulation
DBS0237136[act15]: gpaAgpaAincreased stalk length | aberrant cytokinesis | aberrant fruiting body morphogenesis
DBS0351058[act15]: gpaBgpaBaberrant aggregation | abolished sporulation | development arrests at mound stage | increased cAMP level | aberrant actin filament polymerization | decreased establishment of cell polarity | aberrant protein localization to plasma membrane | increased prestalk cell differentiation
DBS0237145[act15]: gpaGgpaGaberrant fruiting body morphogenesis
DBS0350971[act15]: gpaH/ AX2gpaHaberrant cytokinesis | decreased growth rate | aberrant spore germination | aberrant sorocarp development | increased cell-substrate adhesion | increased cell-cell adhesion
DBS0237147[act15]: gpaI(G38V): FLAGgpaIincreased mound size | delayed aggregation | decreased number of mounds | aberrant fruiting body morphogenesis
DBS0237148[act15]: gpaI(Q196L): FLAGgpaIincreased oscillatory cAMP signaling | decreased protein localization to plasma membrane | increased mound size | aberrant activation of adenylate cyclase activity | increased chemotaxis to cAMP | increased lateral pseudopodium formation | delayed aggregation | decreased number of mounds | increased actin filament polymerization | aberrant adaptation of signaling pathway | aberrant fruiting body morphogenesis | decreased establishment of cell polarity | decreased cGMP biosynthesis
DBS0350079[act15]: grlBgrlBdelayed aggregation
DBS0237149[act15]: grxAgrxAdecreased prespore gene expression | delayed culmination
DBS0237152[act15]: grxA/ [act15]: lacZgrxAincreased cell migration to prestalk region
DBS0351054[act15]: gshBgshBaberrant aggregation | abolished sporulation | increased gene expression | development arrests at mound stage | increased cAMP level | aberrant actin filament polymerization | decreased establishment of cell polarity
DBS0351059[act15]: gshB/ [AS]gpaBgpaBaberrant stream morphology | decreased establishment of cell polarity | decreased sporulation
DBS0351059[act15]: gshB/ [AS]gpaBgshBaberrant stream morphology | decreased establishment of cell polarity | decreased sporulation
DBS0237153[act15]: gsrgsrincreased cell migration to prestalk region | delayed culmination
DBS0350989[act15]: gst4gst4increased fruiting body size
DBS0351173[act15]: htrA(S300A)htrAdecreased growth rate | aberrant fruiting body morphogenesis
DBS0350037[act15]: mekA(299-360)mekAdecreased mound size
DBS0350034[act15]: mekA(K321A)mekAdecreased mound size
DBS0350033[act15]: mekA(S444A/ T448A)mekAdecreased mound size
DBS0237157[act15]: mkkAmkkAdevelopment arrests at mound stage | delayed development
DBS0237158[act15]: mkkA(K199A)mkkAprecocious development | decreased sporulation
DBS0237159[act15]: mkkA{deltaWD40}mkkAdevelopment arrests at mound stage | aberrant fruiting body morphogenesis | delayed development
DBS0350332[act15]: mkpB(C294V)mkpB-1decreased migratory slug size | delayed prestalk gene expression | delayed prespore gene expression | aberrant sorocarp development | decreased resistance to cisplatin
DBS0350332[act15]: mkpB(C294V)mkpB-2decreased migratory slug size | delayed prestalk gene expression | delayed prespore gene expression | aberrant sorocarp development | decreased resistance to cisplatin
DBS0237162[act15]: myc-cdk8cdk8increased number of tip-organizers | precocious development of tipped mound
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcdk8precocious development of tipped mound
DBS0350050[act15]: myc: cdk8/ [act15]: FLAG: cycCcycCprecocious development of tipped mound
DBS0238396[act15]: myc: rapA(G12V)rapAincreased protein localization to cell cortex | delayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0237167[act15]: myc: rckArckAdelayed development
DBS0237163[act15]: myc: rckA(C551A)rckAdelayed slug development | decreased chemotaxis rate
DBS0237164[act15]: myc: rckA(E510G)rckAdelayed slug development | decreased chemotaxis rate
DBS0237165[act15]: myc: rckA(E510G/ N511A)rckAdelayed slug development | decreased chemotaxis rate
DBS0237166[act15]: myc: rckA(K867A)rckAprecocious aggregation | delayed slug development | decreased chemotaxis rate
DBS0351359[act15]: myoBmyoBdecreased pinocytosis | increased protein localization to cell cortex | delayed aggregation | decreased growth rate | decreased cell motility | delayed development | decreased fruiting body size | aberrant actin filament organization
DBS0237175[act15]: myoMmyoMaberrant stream morphology | delayed development | increased pseudopodium size
DBS0237178[act15]: myoM-MtailmyoMdecreased growth rate | aberrant hypotonic response | aberrant stream morphology | aberrant hyperosmotic response | delayed development | increased pseudopodium size
DBS0237179[act15]: myr: rckArckAdelayed development | decreased chemotaxis rate
DBS0351201[act15]: odc: eYFPodcdecreased growth rate | delayed development
DBS0237183[act15]: pakA(K394A)pakAdevelopment arrests at mound stage | delayed development
DBS0237184[act15]: pakA[CA]pakAabolished aggregation
DBS0350901[act15]: pdeE: YFPpdeEdevelopment arrests at loose mound stage | decreased oscillatory cAMP signaling
DBS0349903[act15]: pisApisAaberrant development of tipped mound | decreased slug migration | delayed aggregation | decreased fruiting body size
DBS0349902[act15]: pisA: GFPpisAdecreased slug migration | increased gene expression | decreased gene expression | delayed aggregation | delayed development | decreased phototaxis
DBS0350693[act15]: pkaCpkaCprecocious development
DBS0237188[act15]: pkaC(1-497)pkaCprecocious development | decreased fruiting body size | decreased cAMP level
DBS0237189[act15]: pkaR(G135E/ G261A)pkaRdecreased protein tyrosine phosphorylation | decreased protein kinase activity | abolished cAMP binding | abolished oscillatory cAMP signaling | abolished aggregation
DBS0350609[act15]: pkaR(S133T,G135E)pkaRdecreased cAMP binding | decreased protein kinase activity | abolished oscillatory cAMP signaling | abolished aggregation
DBS0350920[act15]: pkcApkcAincreased catalytic activity | abolished aggregation
DBS0235538[act15]: pldBpldBincreased catalytic activity | increased exocytosis | decreased actin filament polymerization | aberrant chemotaxis to cAMP | abolished aggregation | decreased sporulation
DBS0349874[act15]: psaA: GFPpsaAaberrant sporulation
DBS0351577[act15]: psiApsiAdecreased prespore gene expression | decreased stalk cell differentiation
DBS0350952[act15]: rac1B(T17N)rac1Babolished establishment of cell polarity | delayed aggregation | aberrant actin filament organization | abolished chemotaxis to cAMP
DBS0350262[act15]: rbg3rbg3increased lysosome size | decreased growth rate | delayed development
DBS0350671[act15]: regA(126-316): mycregAprecocious sporulation
DBS0350575[act15]: rps4rps4decreased spore germination | aberrant actin cytoskeleton organization | aberrant vegetative growth | decreased mound size | decreased spore size | aberrant fruiting body morphogenesis | decreased sporulation
DBS0236915[act15]: rzpArzpAincreased prestalk gene expression | decreased prespore gene expression | delayed culmination
HPF437[act15]: snfA(1-379): GFPsnfAincreased stalk width | increased ATP level | decreased growth rate | increased number of mitochondria | decreased defense response to bacterium | decreased phototaxis | decreased stalk length | aberrant mitochondrion organization
DBS0350976[act15]: snfA: YFPsnfAdecreased growth rate | aberrant fruiting body morphogenesis
DBS0351053[act15]: sod2sod2decreased slug migration | decreased fruiting body size | decreased superoxide generation | decreased sporulation
DBS0237194[act15]: sodA: mycsodAaberrant response to abiotic stimulus | decreased gene expression | abolished aggregation
DBS0237195[act15]: spkA: FLAGspkA-1aberrant aggregation | decreased chemotaxis rate | aberrant actin filament organization | decreased establishment of cell polarity
DBS0237195[act15]: spkA: FLAGspkA-2aberrant aggregation | decreased chemotaxis rate | aberrant actin filament organization | decreased establishment of cell polarity
AK1209[act15]: tagA(1-890)tagAincreased number of mound tips
DBS0350862[act15]: tpt1: YFPtpt1decreased gene expression | decreased growth rate | decreased number of mounds | delayed development | aberrant fruiting body morphogenesis
DBS0237199[act15]: trrAtrrAaberrant aggregation | decreased growth rate | decreased phagocytosis | delayed culmination
DBS0351586[act6]: GFP: gefQ(S431A)gefQincreased number of mound tips | delayed development
DBS0350498[act6]: GFP: rab2A(N118I)rab2Aaberrant cell-cell adhesion | aberrant hypotonic response | increased growth rate | precocious development
DBS0350499[act6]: GFP: rab2A(Q64L)rab2Adecreased autophagic cell death | aberrant cell-cell adhesion | aberrant sorocarp development | aberrant hypotonic response | increased growth rate | increased phagocytosis
DBS0235563[act6]: abpD(33-262)abpBdecreased growth rate | delayed development
DBS0350685[act6]: csaAcsaAincreased migratory slug size | increased calcium-independent cell-cell adhesion
DBS0237205[act6]: dia1dia1delayed aggregation
DBS0236905[act6]: mrps4mrps4precocious aggregation
DBS0235444[act6]: myc: eppA(S250A)eppAdecreased growth rate | delayed development | decreased cAMP level
DBS0266836[act6]: ptpBptpBdelayed aggregation | decreased fruiting body size
DBS0237218[act6]: ptpCptpCincreased mound size | decreased growth rate
DBS0237219[act6]: ptpC(C649S)ptpCincreased mound size | decreased growth rate
DBS0350806[act6]: rabS: GFPrabSdecreased cell-cell adhesion | increased secretion of lysosomal enzymes | increased cell death | increased pinocytosis | aberrant sorocarp development | aberrant hyperosmotic response | decreased chemotaxis to cAMP | increased growth rate | increased phagocytosis
DBS0350982[act6]: rps6rps6aberrant cytokinesis | delayed development
DBS0304410[act6]: srsAsrsAincreased migratory slug size | increased mound size | decreased gene expression | delayed aggregation | aberrant fruiting body morphogenesis | decreased sporulation
DBS0237220[act6]: trap1trap1development arrests at loose mound stage | aberrant aggregation | abolished pinocytosis | increased gene expression | decreased gene expression | decreased growth rate
DBS0349955[ampA]: RFP: ampAampAdevelopment arrests at mound stage
DBS0237221[arkA]: arkA: myc2arkAaberrant aggregation
DBS0235407[carA]: carA(1-317)carA-1delayed development
DBS0235407[carA]: carA(1-317)carA-2delayed development
DBS0351495[cotB]: FLAG: fbxDfbxDdelayed culmination
DBS0350705[cotC]: pkaCpkaCaberrant sorocarp development | aberrant fruiting body morphogenesis | precocious development
DBS0351493[dscA]: His: agtAagtAdecreased sporulation
DBS0351492[dscA]: His: agtA(D132A)agtAaberrant stalk morphogenesis | abolished sporulation
DBS0237239[dscB]: GFP: rab8A(N128I)rab8Aincreased mound size | increased cell-cell adhesion | decreased fruiting body size
DBS0237240[dscB]: GFP: rab8A(Q74L)rab8Aabolished aggregation | aberrant cytoskeleton organization
DBS0237241[dscB]: GFP: rab8Brab8Bincreased mound size
DBS0237242[dscB]: GFP: rab8B(Q74L)rab8Bincreased mound size
DBS0350820[dscB]: cafAcafAincreased gene expression | precocious development
DBS0350922[dscB]: dicA(1-278)dicAincreased cell death | abolished protein binding | aberrant microtubule cytoskeleton organization | aberrant Golgi localization | aberrant mitotic sister chromatid segregation | aberrant centrosome organization
DBS0237243[dscB]: myc: rac1Brac1Bincreased rate of endocytosis | aberrant cytokinesis | decreased growth rate | delayed development
DBS0237244[dscB]: myc: rac1B(G12V)rac1Bdecreased rate of endocytosis | decreased growth rate | abolished aggregation | aberrant cell morphology
DBS0237245[dscB]: myc: rac1B(Q61L)rac1Bdecreased rate of endocytosis | decreased growth rate | abolished aggregation | aberrant cell morphology
DBS0237246[dscB]: myc: rac1B(T17N)rac1Bdecreased rate of endocytosis | decreased growth rate | abolished aggregation
DBS0351510[dscB]: rac1B(G12V): mycrac1Bdecreased pinocytosis | decreased growth rate | aberrant cytokinesis | delayed development | aberrant actin filament organization | aberrant cell morphology
DBS0351511[dscB]: rac1B(Q61L): mycrac1Bdecreased growth rate | aberrant cytokinesis | delayed development | aberrant actin filament organization | aberrant cell morphology
DBS0351512[dscB]: rac1B(T17N): mycrac1Bdecreased pinocytosis | decreased growth rate | aberrant cytokinesis | decreased chemotaxis to folate | delayed development | aberrant actin filament polymerization | aberrant cell morphology
DBS0237248[dscB]: rasG(G12T)rasGdecreased gene expression | decreased growth rate | increased cell-cell adhesion | decreased cell motility | decreased protein kinase activation | decreased fruiting body size | abolished aggregation | aberrant cell morphology | decreased sporulation
DBS0351230[ecmAO]: rasG(G12T)rasGaberrant prestalk gene expression | aberrant culmination
DBS0350703[ecmA]: pkaCpkaCdevelopment arrests at mound stage | abolished development of tipped mound
DBS0350659[ecmA]: pkaC(9-648)pkaCdevelopment arrests at tipped mound stage
DBS0350699[ecmA]: pkaR(G135E/ G261A)pkaRdecreased migratory slug size | delayed development of tipped mound | aberrant culmination | aberrant slug migration | decreased prestalk gene expression | increased slug migration | aberrant prestalk cell differentiation
DBS0350700[ecmA]: pkaR(G135E/ G261A)/ [ecmB-frag]: lacZpkaRabolished stalk cell differentiation
DBS0350704[ecmB]: pkaCpkaCdevelopment arrests at mound stage | abolished development of tipped mound
DBS0350639[ecmF]: expl3: mycexpl3aberrant stalk morphogenesis | delayed slug development
DBS0304865[expl7]: expl7: GFPexpl7aberrant late culminant morphology
DBS0237252[gpaA]: gpaA(G45V)gpaAdelayed development
DBS0237253[gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0349948[ndm]: ndm: RFPndmdevelopment arrests at mound stage
DBS0236086[pdsA-agg]: pdsApdsAprecocious development
DBS0236111[pdsA-ldev]: pdsApdsAdevelopment arrests at mound stage
DBS0236484[pkaC]: pkaCpkaCincreased gene expression | precocious prespore gene expression | decreased spore cell differentiation | aberrant fruiting body morphogenesis | precocious development | precocious gene expression | decreased cAMP level
DBS0350196[pkaC]: pkaC/ nsfA(A1854T,T1984A,C2131A,A2398T,T2574A)nsfAdecreased spore cell differentiation
DBS0350196[pkaC]: pkaC/ nsfA(A1854T,T1984A,C2131A,A2398T,T2574A)pkaCdecreased spore cell differentiation
DBS0350696[pkaC]: pkaC/ srfA-pkaCaberrant spore coat morphology | aberrant gene expression
DBS0350696[pkaC]: pkaC/ srfA-srfAaberrant spore coat morphology | aberrant gene expression
DBS0237289[psmC1]: psmC1psmC1delayed development of tipped mound | aberrant cytokinesis | delayed gene expression
DBS0350658[pspA]: pkaC(9-648)pkaCprecocious sporulation | aberrant fruiting body morphogenesis
DBS0350697[pspA]: pkaR(G135E/ G261A)pkaRabolished gene expression | decreased prespore gene expression | aberrant sorus color
DBS0351229[pspA]: rasG(G12T)rasGincreased number of mound tips | increased prestalk gene expression | decreased prespore gene expression | abolished phototaxis | increased prestalk cell differentiation
DBS0237290[ptpA1]: ptpA1ptpA1-1delayed aggregation | decreased growth rate | aberrant fruiting body morphogenesis
DBS0237290[ptpA1]: ptpA1ptpA1-2delayed aggregation | decreased growth rate | aberrant fruiting body morphogenesis
DBS0237291[ptpB]ptpBptpBdecreased growth rate | development arrests at mound stage
DBS0351231[rasD]: rasG(G12T)rasGdevelopment arrests at loose mound stage | increased number of mound tips
DBS0236867[rasG]: rasG(G12T)rasGaberrant aggregation
DBS0238351[tet]: [RNAi]cinCcinCdecreased translation | precocious aggregation | decreased growth rate
DBS0351461[tet]rasD(G12T)rasDincreased gene expression | increased prestalk cell differentiation
DBS0350494[tgrB1]: [RNAi]abcB3/ [tgrC1]: GFPabcB3delayed development | decreased cAMP level
DBS0304911[tre]: paxBpaxBabolished sporulation | aberrant endocytosis | decreased cell-substrate adhesion | aberrant chemotaxis to folate | development arrests at mound stage | decreased cell motility | increased cell-cell adhesion
DBS0350267[tre]: secGsecGincreased filopodium formation | abolished establishment of cell polarity | development arrests at mound stage | aberrant actin cytoskeleton organization | aberrant actin filament polymerization | abolished chemotaxis to cAMP | delayed gene expression
DBS0351454[unk]: GFP: piaA(G963E)piaAdelayed aggregation | decreased protein binding
DBS0350447[unk]: PTEN(H385G/ N389A/ H390A)ptendecreased protein localization to plasma membrane | decreased fruiting body size
DBS0351270[unk]: gpgA(1-65)gpgAdecreased protein localization to plasma membrane | abolished aggregation | aberrant actin filament organization | abolished chemotaxis to cAMP
DBS0236859[unk]: rasD(G12T)rasDincreased myo-inositol level | decreased gene expression | increased prestalk gene expression | decreased prespore gene expression | development arrests at tipped mound stage | increased protein kinase activation
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArapAincreased number of mound tips | aberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation
DBS0350837[unk]: rasD(G12T)/ [rasD]: rapArasDincreased number of mound tips | aberrant culmination | decreased prespore cell differentiation | aberrant gene expression | decreased stalk cell differentiation
DBS0237288[unk]skp1fpaAaberrant fruiting body morphogenesis
DBS0237288[unk]skp1fpaB-1aberrant fruiting body morphogenesis
HAD186aarA-aarAaberrant stalk morphogenesis | aberrant Golgi localization | aberrant epithelium-like organization | decreased prespore gene expression | aberrant centrosome localization | aberrant stalk development | aberrant establishment or maintenance of cell polarity | decreased sporulation
DBS0349920aarA-/ [act15]: GFP-mhcAaarAaberrant stalk morphogenesis | aberrant protein localization
DBS0350143abcA10-abcA10aberrant sorocarp development | decreased sporulation
DBS0350135abcA3-abcA3aberrant sorocarp development | aberrant fruiting body morphogenesis | decreased sporulation
DBS0350138abcA4-abcA4aberrant fruiting body morphogenesis
DBS0350139abcA5-abcA5aberrant sorocarp development | decreased sporulation
DBS0350140abcA6-abcA6decreased fruiting body size
DBS0350142abcA9-abcA9aberrant fruiting body morphogenesis | decreased sporulation
DBS0350145abcB1-abcB1delayed culmination
DBS0350146abcB4-abcB4decreased sporulation
DBS0350147abcB5-abcB5decreased growth rate | delayed culmination
DBS0350153abcC13-abcC13aberrant sorocarp development | delayed culmination | decreased sporulation
DBS0350154abcC14-abcC14aberrant sorocarp development | decreased fruiting body size | decreased sporulation
DBS0350148abcC2-abcC2aberrant sorocarp development | delayed culmination
DBS0350149abcC3-abcC3delayed culmination
DBS0350150abcC6-abcC6aberrant sorocarp development | delayed culmination
DBS0350151abcC8-abcC8decreased growth rate | increased number of early culminant tips | decreased sporulation
DBS0350155abcD2-abcD2decreased fruiting body size
DBS0350156abcF1-abcF1aberrant sorocarp development | delayed culmination | decreased sporulation
DBS0350157abcF2-abcF2delayed development of tipped mound | decreased sporulation
DBS0350158abcF4-abcF4aberrant sorocarp development | aberrant fruiting body morphogenesis
DBS0350164abcG10-abcG10delayed development of tipped mound | decreased fruiting body size | decreased sporulation
DBS0350165abcG15-abcG15aberrant sorocarp development | decreased sporulation
DBS0350166abcG16-abcG16delayed culmination
DBS0350167abcG17-abcG17-1decreased fruiting body size | decreased sporulation
DBS0350167abcG17-abcG17-2decreased fruiting body size | decreased sporulation
DBS0350168abcG18-abcG18decreased sporulation
DBS0350169abcG19-abcG19delayed aggregation | decreased fruiting body size
DBS0350160abcG2-abcG2delayed development of tipped mound | decreased fruiting body size
DBS0350170abcG22-abcG22delayed development of tipped mound | aberrant sorocarp development
DBS0350171abcG24-abcG24decreased sporulation | delayed culmination
DBS0350161abcG5-abcG5delayed culmination
DBS0350162abcG6-abcG6decreased sporulation
DBS0351078abcG6-abcG6delayed aggregation | increased cell-substrate adhesion | decreased cell motility
DBS0350163abcG7-abcG7delayed development of tipped mound | decreased fruiting body size | decreased sporulation
DBS0350159abcH2-abcH2decreased sporulation
DBS0351531abiA-/ AX2abiAabolished protein localization to pseudopodium | decreased migratory slug size | aberrant filopodium formation | aberrant macropinocytosis | decreased cell motility | aberrant pseudopodium formation | decreased fruiting body size
LAS53abkD-abkDaberrant socially cooperative development
DBS0351065abnC-abnCdelayed aggregation | increased cell-substrate adhesion | decreased cell motility
DBS0351087abpB-/ abpA-abpAdecreased pinocytosis | decreased growth rate | increased cell-cell adhesion | decreased vegetative cell size | aberrant fruiting body morphogenesis | aberrant hyperosmotic response | precocious gene expression | decreased chemotaxis to cAMP
DBS0351087abpB-/ abpA-abpBdecreased pinocytosis | decreased growth rate | increased cell-cell adhesion | decreased vegetative cell size | aberrant fruiting body morphogenesis | aberrant hyperosmotic response | precocious gene expression | decreased chemotaxis to cAMP
DBS0351088abpB-/ abpC-abpBdecreased prespore gene expression | decreased prestalk gene expression | aberrant fruiting body morphogenesis | aberrant hyperosmotic response | decreased chemotaxis to cAMP
DBS0351088abpB-/ abpC-abpCdecreased prespore gene expression | decreased prestalk gene expression | aberrant fruiting body morphogenesis | aberrant hyperosmotic response | decreased chemotaxis to cAMP
DBS0235425abpB-/ fimA-abpBdecreased vegetative cell size | decreased fruiting body size | decreased sporulation
DBS0235425abpB-/ fimA-fimAdecreased vegetative cell size | decreased fruiting body size | decreased sporulation
DBS0235427abpD-abpDdecreased cell-cell adhesion | decreased spore germination | aberrant sorocarp development | delayed development
DBS0350529abpG-abpGincreased actin filament polymerization | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0235562acaA-acaAabolished stream development | abolished gene expression | abolished establishment of cell polarity | decreased gene expression | increased cellular thermotolerance | abolished aggregation | decreased adenylate cyclase activity | decreased cAMP level
DBS0350720acaA-/ [acaA-agg]: acaA: mycacaAdecreased gene expression | decreased fruiting body size
DBS0350721acaA-/ [acaA-psp]: acaA: mycacaAdecreased gene expression | decreased mound size | decreased fruiting body size
DBS0350702acaA-/ [act15]: HA: pkaCacaAwild type | delayed development | decreased cAMP level
DBS0350702acaA-/ [act15]: HA: pkaCpkaCwild type | delayed development | decreased cAMP level
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acaAdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-acrAdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350725acaA-/ [act15]: HA: pkaC/ acrA-pkaCdecreased gene expression | abolished adenylate cyclase activity | development arrests at tipped mound stage
DBS0350737acaA-/ [act15]: acaAacaAaberrant slug development
DBS0350738acaA-/ [act15]: acaA(1-390;398-1407)acaAabolished aggregation
DBS0350603acaA-/ [act15]: cap: GFPacaAdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350603acaA-/ [act15]: cap: GFPcapdevelopment arrests at loose mound stage | increased calcium-dependent cell-cell adhesion | wild type
DBS0350051acapA-acapAaberrant exocytosis | aberrant filopodium formation | increased defense response to Gram-negative bacterium | aberrant endocytosis | aberrant cytokinesis | aberrant stream morphology | decreased cell motility | delayed development | aberrant lysosome organization
DBS0306126acapA-/ acapB-acapAdecreased sporulation
DBS0306126acapA-/ acapB-acapBdecreased sporulation
TL177acbA-acbAdecreased response to Gram-negative bacterium | abolished cell migration to prestalk region | abolished spore cell differentiation | decreased sporulation | decreased resistance to cisplatin
DBS0350194acbA-/ [act15]: acbA(Y72A)acbAabolished spore cell differentiation
AK1211acbA-/ tagA-acbAincreased prestalk B cell differentiation
AK1211acbA-/ tagA-tagAincreased prestalk B cell differentiation
DBS0235440acgA-acgAabolished polyketide metabolic process | decreased spore germination | decreased spore cell differentiation | precocious spore germination | abolished response to biotic stimulus
DBS0237788acgA-acgAdecreased prespore cell differentiation | decreased prespore gene expression
DG1100acrA-acrAdecreased gene expression | increased stalk length | decreased prespore gene expression | decreased sporulation
DBS0349939acrA-acrAaberrant spore coat morphology | decreased stalk width
DBS0350723acrA-/ [act15]: acaA(L394S)acaAprecocious spore germination
DBS0350723acrA-/ [act15]: acaA(L394S)acrAprecocious spore germination
DBS0237786acrA-/ [act15]: acgA(1-401)acgAdecreased prespore gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0237786acrA-/ [act15]: acgA(1-401)acrAdecreased prespore gene expression | decreased prespore cell differentiation | decreased sporulation
DBS0350724acrA-/ [pkaC]: pkaCacrAdecreased spore germination | decreased fruiting body size | precocious development | decreased sporulation
DBS0350724acrA-/ [pkaC]: pkaCpkaCdecreased spore germination | decreased fruiting body size | precocious development | decreased sporulation
DBS0351249act5-/ [act5]: RFP/ NC4act5increased chemotaxis to folate | increased fruiting body size | increased growth rate
DBS0350445adcC-/ adcB-adcBincreased oscillatory cAMP signaling | aberrant endocytosis | delayed aggregation | aberrant regulation of protein kinase activity
DBS0350445adcC-/ adcB-adcCincreased oscillatory cAMP signaling | aberrant endocytosis | delayed aggregation | aberrant regulation of protein kinase activity
DBS0351248adprt1A-adprt1Adecreased gene expression | increased gene expression | decreased ATP level | delayed mitotic cell cycle | decreased growth rate | delayed aggregation | increased prestalk gene expression | decreased mound size | aberrant response to oxidative stress | decreased fruiting body size | increased mitochondrial fission | decreased cAMP level | abolished chemotaxis to cAMP
DBS0238203adrm1-adrm1-1decreased catalytic activity | precocious gene expression | aberrant response to nutrient | precocious development
HW420agtA-agtAdevelopment arrests at slug stage
HW520agtA-/ gnt1(1-253/ H104D)agtAdevelopment arrests at slug stage
HW520agtA-/ gnt1(1-253/ H104D)gnt1development arrests at slug stage
DBS0235457ahhA-ahhAaberrant late culminant morphology
DBS0235513alrA-alrAincreased mound size | decreased cell motility | decreased glucose level | decreased protein secretion
DBS0235474alxA-alxAdevelopment arrests at loose mound stage | aberrant standing slug morphology | decreased growth rate
DBS0235475alxA-alxAabolished sporulation | aberrant standing slug morphology | aberrant cellular process | decreased gene expression | development arrests at mound stage
DBS0235488alxA-/ [act15]: FLAG: alxAalxAdelayed development
DBS0235476alxA-/ [act15]: alxA(1-596): myc2alxAaberrant standing slug morphology
DBS0235478alxA-/ [act15]: alxA(155-697): myc2alxAaberrant standing slug morphology
DBS0235479alxA-/ [act15]: alxA(293-697): myc2alxAaberrant standing slug morphology
DBS0235480alxA-/ [act15]: alxA(460-794): myc2alxAaberrant standing slug morphology
DG1114amdA-amdAdecreased spore germination | aberrant sorus color | increased prestalk A cell differentiation
HM1158amdA-amdAdecreased fruiting body size | decreased sporulation | increased cell differentiation
DBS0235490amiB-amiBabolished aggregation
DBS0235491amiB-amiBaberrant cell motility | increased gene expression | decreased gene expression | decreased oscillatory cAMP signaling | decreased cGMP-mediated signaling | abolished aggregation | decreased chemotaxis to cAMP
DBS0235493ampA-ampAdelayed development of tipped mound | delayed prestalk gene expression | precocious prespore gene expression | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant gene expression | delayed development | decreased prestalk cell differentiation
DBS0349953ampA/ [ampA]: TAPampAincreased protein secretion | development arrests at mound stage
BS155amtA-amtAdecreased slug migration | decreased mound size | decreased fruiting body size | increased growth rate | decreased ammonia level
DBS0267100amtA-amtAincreased number of mounds | increased glucose level | decreased mound size | decreased ammonia level | decreased stalk length | aberrant sporulation | increased intracellular ammonia level
BS165amtA-/ amtC-amtAdecreased protein localization to nucleus | aberrant slug migration | decreased ammonia level | delayed gene expression
BS165amtA-/ amtC-amtCdecreased protein localization to nucleus | aberrant slug migration | decreased ammonia level | delayed gene expression
BS154amtC-amtCabolished protein localization to nucleus | development arrests at slug stage | aberrant gene expression | decreased prestalk gene expression | aberrant fruiting body morphogenesis | decreased ammonia level | delayed culmination
DBS0235501amtC-/ [act15]: cudAamtCdelayed culmination
DBS0235501amtC-/ [act15]: cudAcudAdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAamtCdelayed culmination
DBS0235502amtC-/ [ecmA]: cudAcudAdelayed culmination
DBS0235503amtC-/ [pspA]: cudAamtCdevelopment arrests at slug stage
DBS0235503amtC-/ [pspA]: cudAcudAdevelopment arrests at slug stage
DBS0236890amtC-/ regA-amtCprecocious sporulation
DBS0236890amtC-/ regA-regAprecocious sporulation
DBS0349869ap1b1-ap1b1aberrant aggregation | aberrant cell separation during cytokinesis | aberrant contractile vacuole organization | decreased growth rate | aberrant hypotonic response | decreased protein stabilization
DBS0350296aph1-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350299aph1-/ ncstn-aph1decreased phagocytosis | decreased prespore cell differentiation
DBS0350299aph1-/ ncstn-ncstndecreased phagocytosis | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-aph1aberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350300aph1-/ psenA-psenAaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0235505apm1-apm1decreased spore germination | aberrant contractile vacuole organization | decreased growth rate | aberrant endosome morphology | aberrant hypotonic response | delayed development | decreased stalk width
DBS0235509aprA-aprAaberrant cellular homeostasis | increased mound size | decreased spore germination | increased cell death | aberrant cytokinesis | aberrant vegetative growth | aberrant fruiting body morphogenesis | increased growth rate | abolished chemorepellant activity | decreased sporulation
DBS0235510aprA-/ [act15]: aprAaprAdecreased growth rate | aberrant fruiting body morphogenesis
DBS0238124aqpA-aqpAdecreased spore germination | decreased sporulation
DBS0351067araA-araAdelayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0235511arkA-arkAincreased gene expression | aberrant fruiting body morphogenesis
DBS0235512arkA-/ [arkA]: arkA: myc2arkAaberrant aggregation
DBS0349998arpB+/ aprB-/ [act15]: myc: arpB(Y200F/ T235A/ T236A)arpBdecreased actin filament polymerization | delayed aggregation | decreased fruiting body size | decreased establishment of cell polarity | decreased chemotaxis to cAMP | delayed gene expression
HR131atg1-atg1abolished macroautophagy | increased number of autophagosomes | aberrant autophagy | decreased defense response to Gram-negative bacterium | aberrant cellular response to nitrogen starvation | decreased growth rate | abolished spore cell differentiation | aberrant vacuole organization | abolished stalk cell differentiation | abolished aggregation | increased defense response to fungus | decreased defense response to Gram-positive bacterium | aberrant protein localization
DBS0238092atg1-/ [act15]: atg1(1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238087atg1-/ [act15]: atg1(K36A)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238089atg1-/ [act15]: atg1(K36A/ 1-628)atg1aberrant cellular response to nitrogen starvation | abolished aggregation
DBS0238093atg1-/ [act15]: atg1(P138S)atg1abolished aggregation
DBS0266655atg1-/ iplA-atg1decreased necrotic cell death
DBS0266655atg1-/ iplA-iplAdecreased necrotic cell death
DBS0350884atg101-atg101increased number of tip-organizers | decreased autophagy
DBS0351232atg12-atg12decreased pinocytosis | increased cell death | decreased spore germination | decreased catalytic activity | increased gene expression | increased number of mound tips | increased protein modification | decreased phagocytosis | aberrant phagosome maturation | aberrant fruiting body morphogenesis
DBS0351233atg12-/ tipD-atg12decreased pinocytosis | increased cell death | decreased spore germination | increased gene expression | increased number of mound tips | increased protein modification | decreased phagocytosis | aberrant phagosome maturation | aberrant fruiting body morphogenesis
DBS0351233atg12-/ tipD-tipDdecreased pinocytosis | increased cell death | decreased spore germination | increased gene expression | increased number of mound tips | increased protein modification | decreased phagocytosis | aberrant phagosome maturation | aberrant fruiting body morphogenesis
DBS0350883atg13-atg13aberrant autophagy | abolished aggregation
HR75atg5-atg5increased number of tip-organizers | aberrant macroautophagy | abolished sporulation | aberrant cellular response to nitrogen starvation | abolished aggregation | aberrant protein localization
DBS0351478atg5-atg5abolished sporulation | decreased gene expression | delayed development
DBS0351582atg5-atg5increased cell death | decreased catalytic activity | decreased growth rate | aberrant phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis | increased growth rate
DBS0351583atg5-/ atg12-atg12increased cell death | decreased catalytic activity | decreased growth rate | decreased phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis
DBS0351583atg5-/ atg12-atg5increased cell death | decreased catalytic activity | decreased growth rate | decreased phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis
DBS0351584atg5-/ atg12-/ tipD-atg12increased cell death | decreased catalytic activity | decreased growth rate | aberrant phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis | increased growth rate
DBS0351584atg5-/ atg12-/ tipD-atg5increased cell death | decreased catalytic activity | decreased growth rate | aberrant phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis | increased growth rate
DBS0351584atg5-/ atg12-/ tipD-tipDincreased cell death | decreased catalytic activity | decreased growth rate | aberrant phagocytosis | increased protein modification | decreased macropinocytosis | aberrant fruiting body morphogenesis | increased growth rate
HR174 atg6-atg6Aincreased number of tip-organizers | aberrant macroautophagy | decreased defense response to Gram-negative bacterium | aberrant cellular response to nitrogen starvation | decreased spore cell differentiation | decreased defense response to fungus | decreased fruiting body size | decreased stalk length | decreased sporulation
HR79atg7-atg7increased number of tip-organizers | aberrant macroautophagy | abolished sporulation | decreased defense response to Gram-negative bacterium | aberrant cellular response to nitrogen starvation | abolished spore cell differentiation | aberrant protein localization
DBS0351476atg7-atg7aberrant sorus morphology | decreased spore germination | decreased gene expression | decreased prespore cell differentiation | delayed development
DBS0351477atg7-/ [act15]: YFP: atg7(C563A)atg7aberrant sorus morphology | decreased spore germination | delayed development
DBS0351479atg7-/ [act15]: pkaC: YFPatg7decreased gene expression | decreased sporulation
DBS0351479atg7-/ [act15]: pkaC: YFPpkaCdecreased gene expression | decreased sporulation
HR141atg8-atg8aincreased number of tip-organizers | aberrant macroautophagy | aberrant spore morphology | aberrant cellular response to nitrogen starvation | decreased spore cell differentiation | aberrant vacuole organization | decreased fruiting body size | decreased defense response to Gram-positive bacterium | decreased sporulation
DBS0351222atg8a-atg8aincreased cell death | decreased catalytic activity | increased number of mound tips | decreased growth rate | decreased phagocytosis | increased protein modification | delayed development | decreased fruiting body size | aberrant lysosome organization
DBS0351224atg8a-/ atg8b-atg8aincreased cell death | decreased catalytic activity | decreased growth rate | decreased phagocytosis | increased protein modification | aberrant sorocarp development | aberrant lysosome organization
DBS0351224atg8a-/ atg8b-atg8bincreased cell death | decreased catalytic activity | decreased growth rate | decreased phagocytosis | increased protein modification | aberrant sorocarp development | aberrant lysosome organization
DBS0351223atg8b-atg8bprecocious development | aberrant lysosome organization
DBS0305977atg9-atg9increased stalk width | decreased pinocytosis | abolished sporulation | aberrant sorus morphology | aberrant autophagy | decreased protein localization to autophagosome | increased number of mound tips | decreased gene expression | decreased phagocytosis | decreased growth rate | abolished catalytic activity | aberrant slug development | aberrant slug migration | aberrant protein modification | aberrant phagosome maturation | decreased prespore cell differentiation | aberrant fruiting body morphogenesis | delayed development | abolished phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPatg9decreased growth rate | aberrant fruiting body morphogenesis | abolished phototaxis
DBS0350534atg9-/ [act15]: cdcD: RFPcdcDdecreased growth rate | aberrant fruiting body morphogenesis | abolished phototaxis
DBS0351480atg9-/ [act15]: pkaC: YFPatg9abolished sporulation
DBS0351480atg9-/ [act15]: pkaC: YFPpkaCabolished sporulation
DBS0350731atg9-/ tipD-atg9decreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0350731atg9-/ tipD-tipDdecreased pinocytosis | aberrant phagosome maturation | development arrests at tipped mound stage
DBS0351503bcas3-bcas3decreased number of autophagosomes | aberrant fruiting body morphogenesis | aberrant phototaxis | decreased sporulation
DBS0351039bzpF-bzpFdecreased spore germination | decreased gene expression | aberrant fruiting body morphogenesis | aberrant sporulation | decreased sporulation
DBS0350419bzpR-bzpRincreased stalk width | aberrant sorus morphology | decreased sporulation
TL97cadA-cadAincreased number of tip-organizers | decreased calcium-dependent cell-cell adhesion | decreased protein level | increased gene expression | abolished cell migration to prestalk region | increased chemotaxis to cAMP | aberrant cytokinesis | decreased sporulation | delayed culmination | increased prestalk cell differentiation
DBS0235561cap-capdecreased protein level | aberrant pinocytosis | aberrant contractile vacuole organization | aberrant cytokinesis | decreased cell motility | delayed development | aberrant response to osmotic stress
JB4carA-carA-1abolished aggregation
JB4carA-carA-2abolished aggregation
JS14carA-carA-1abolished protein tyrosine phosphorylation | abolished protein localization to nucleus | aberrant phagocytosis | increased cell-substrate adhesion | decreased oscillatory cAMP signaling | decreased cGMP-mediated signaling | aberrant regulation of GTPase activity | abolished aggregation | aberrant regulation of protein kinase activity | abolished chemotaxis to cAMP
JS14carA-carA-2abolished protein tyrosine phosphorylation | abolished protein localization to nucleus | aberrant phagocytosis | increased cell-substrate adhesion | decreased oscillatory cAMP signaling | decreased cGMP-mediated signaling | aberrant regulation of GTPase activity | abolished aggregation | aberrant regulation of protein kinase activity | abolished chemotaxis to cAMP
DBS0351266carA-/ [act15]: gpbA: YFPcarA-1abolished aggregation
DBS0351266carA-/ [act15]: gpbA: YFPcarA-2abolished aggregation
DBS0351266carA-/ [act15]: gpbA: YFPgpbAabolished aggregation
RI4carA-/ carC-carA-1decreased actin filament polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cGMP-mediated signaling | abolished chemotaxis to cAMP
RI4carA-/ carC-carA-2decreased actin filament polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cGMP-mediated signaling | abolished chemotaxis to cAMP
RI4carA-/ carC-carCdecreased actin filament polymerization | abolished activation of GTPase activity | abolished aggregation | abolished cGMP-mediated signaling | abolished chemotaxis to cAMP
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-1abolished stream development | aberrant activation of adenylate cyclase activity | aberrant chemotaxis to cAMP | aberrant oscillatory cAMP signaling | aberrant actin filament polymerization
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carA-2abolished stream development | aberrant activation of adenylate cyclase activity | aberrant chemotaxis to cAMP | aberrant oscillatory cAMP signaling | aberrant actin filament polymerization
DBS0350568carA-/ carC-/ [act15]: carA(261-359;S299A,S302G,S303G,S304G,S308A,S324G,S325A,S331A)(369-392;S383A,S385A)carCabolished stream development | aberrant activation of adenylate cyclase activity | aberrant chemotaxis to cAMP | aberrant oscillatory cAMP signaling | aberrant actin filament polymerization
DBS0235570carB-carBdevelopment arrests at mound stage
DBS0350661carB-carBdevelopment arrests at mound stage | abolished development of tipped mound | increased prespore gene expression | decreased prestalk gene expression
DBS0235568carD-carDdecreased migratory slug size | decreased slug migration | increased prespore gene expression | decreased prestalk gene expression | aberrant slug migration | aberrant fruiting body morphogenesis | decreased stalk length | decreased prestalk cell differentiation
DBS0235573carmil-carmildecreased pinocytosis | decreased actin filament polymerization | decreased growth rate | decreased mound size
DBS0235574catB-catBdecreased spore resistance to hydrogen peroxide | aberrant gene expression | delayed development | delayed gene expression
DBS0350249cbhA-cbhAdelayed development
DBS0304455cblA-cblA-1aberrant slug development | abolished basal disc formation | aberrant signal transduction
DBS0304455cblA-cblA-2aberrant slug development | abolished basal disc formation | aberrant signal transduction
DBS0235661cdk8-cdk8decreased gene expression | aberrant gene expression | abolished aggregation
DBS0350435cdk8-cdk8decreased spore germination | decreased gene expression | aberrant gene expression | abolished aggregation
DBS0350437cdk8-/ [act15]: myc: cdk8(D194A)cdk8decreased spore germination | abolished aggregation
DBS0350265cepK-cepKdecreased protein level | decreased protein localization to nuclear envelope | aberrant chemotaxis to cAMP | decreased growth rate | decreased mound size | decreased vegetative cell size | decreased fruiting body size
DBS0302444cfaD-cfaDaberrant cellular homeostasis | increased cell death | decreased spore germination | aberrant vegetative growth | aberrant cytokinesis | aberrant fruiting body morphogenesis | increased growth rate | decreased sporulation
HO103chcA-chcAabolished sporulation | abolished cytokinesis | abolished gene expression | delayed aggregation | abolished vegetative growth | aberrant fruiting body morphogenesis
DBS0350524chdA-chdAaberrant culmination | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350525chdB-chdBaberrant gene expression | delayed development
DBS0350526chdC-chdCdecreased growth rate | development arrests at mound stage | aberrant gene expression | aberrant chromatin assembly | decreased chemotaxis to cAMP
DBS0350528chdC-/ [ecmA]: lacZchdCdecreased prestalk cell differentiation
DBS0350527chdC-/ [pspA]: lacZchdCdecreased prespore cell differentiation
HM1522chlA-chlAabolished DIF-1 biosynthesis | aberrant slug development | aberrant fruiting body morphogenesis
LAS1chtB-chtBdecreased socially cooperative development | increased growth rate
CCR2chtC-chtCdecreased socially cooperative development | decreased prestalk A cell differentiation
LAS5chtC-REMIchtCdecreased socially cooperative development
DBS0305614chtC-inschtCdecreased socially cooperative development | decreased prestalk A cell differentiation
DBS0235601clc-clcabolished cytokinesis | decreased protein localization to plasma membrane | aberrant hypotonic response | abolished vegetative growth | aberrant fruiting body morphogenesis
DBS0235604clc-/ [act15]: GFP-clc(146-194)clcabolished cytokinesis | wild type | aberrant fruiting body morphogenesis
DBS0235605clc-/ [act15]: GFP-clc(85-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphogenesis
DBS0235607clc-/ [act15]GFP: clc(1-124)clcabolished cytokinesis | wild type | aberrant fruiting body morphogenesis
DBS0350473cln3-cln3aberrant aggregation | increased protein secretion | aberrant cell separation during cytokinesis | decreased hypotonic response | aberrant cellular process | increased pinocytosis | delayed aggregation | aberrant cell adhesion | aberrant slug migration | aberrant hyperosmotic response | precocious development | increased growth rate | decreased chemotaxis to cAMP | decreased protein secretion
DBS0235612cmfB-cmfBdecreased gene expression | abolished aggregation
DBS0302655cnrN-cnrNincreased oscillatory cAMP signaling | increased number of mounds | decreased spore germination | increased actin filament polymerization | aberrant cytokinesis | aberrant stream morphology | increased growth rate | abolished positive regulation of chemorepellant activity | decreased sporulation
DG1016comB-comBabolished culmination
DBS0235618comC-comCaberrant aggregation | aberrant stream morphology
DBS0235619comD-comDabolished culmination
DBS0235620comE-comEaberrant fruiting body morphogenesis | aberrant sorus color
DBS0235621comF-comF-1abolished aggregation
DBS0235621comF-comF-2abolished aggregation
DBS0235622comG-comGincreased number of tip-organizers | development arrests at mound stage
DBS0235623comH-comHdevelopment arrests at mound stage
DBS0350370corA-corAdecreased defense response to Gram-negative bacterium | decreased gene expression | aberrant chemotaxis to cAMP | aberrant response to cAMP | decreased phagocytosis | aberrant cellular response to extracellular stimulus | decreased establishment of cell polarity | abolished aggregation
DBS0351521corA-/ [act15]: FLAG: corA(1-432)corAabolished aggregation
DBS0350851corA-/ aip1-aip1aberrant endocytosis | aberrant cytokinesis | increased actin filament polymerization | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased vegetative cell size | increased protein level | decreased chemotaxis to cAMP
DBS0350851corA-/ aip1-corAaberrant endocytosis | aberrant cytokinesis | increased actin filament polymerization | development arrests at mound stage | decreased growth rate | aberrant nucleus morphology | increased vegetative cell size | increased protein level | decreased chemotaxis to cAMP
DBS0349942cosA-cosAdecreased cell motility | decreased fruiting body size | decreased chemotaxis to cAMP | aberrant actin filament organization | increased pseudopodium formation
TL55cotA-cotAdecreased spore germination | aberrant spore coat morphology | abolished cellulose binding
TL53cotA-/ cotB-cotAaberrant spore coat morphology
TL53cotA-/ cotB-cotBaberrant spore coat morphology
TL56cotA-/ cotB-/ cotC-cotAdecreased spore germination | aberrant spore coat morphology | abolished cellulose binding
TL56cotA-/ cotB-/ cotC-cotBdecreased spore germination | aberrant spore coat morphology | abolished cellulose binding
TL56cotA-/ cotB-/ cotC-cotCdecreased spore germination | aberrant spore coat morphology | abolished cellulose binding
TL57cotA-/ cotB-/ cotC-cotAaberrant spore coat morphology
TL57cotA-/ cotB-/ cotC-cotBaberrant spore coat morphology
TL57cotA-/ cotB-/ cotC-cotCaberrant spore coat morphology
TL26cotB-cotBdecreased spore germination | aberrant spore coat morphology | abolished cellulose binding
TL54cotB-/ cotC-cotBaberrant spore coat morphology
TL54cotB-/ cotC-cotCaberrant spore coat morphology
TL52cotC-cotCaberrant spore coat morphology
HW07cotE(1-235)cotEaberrant spore coat morphology
DBS0351045cox3-cox3decreased defense response to Gram-negative bacterium | decreased gene expression | decreased growth rate | aberrant fruiting body morphogenesis | aberrant phototaxis
DBS0238297cpnA-/ NC4A2cpnAdelayed hypotonic response | increased migratory slug size | decreased post-lysosomal vacuole size | increased mound size | aberrant thermotaxis | increased contractile vacuole size | increased exocytosis | decreased growth rate | aberrant cytokinesis | aberrant stalk cell differentiation | development arrests at slug stage | decreased number of post-lysosomal vacuoles | aberrant fruiting body morphogenesis | delayed development | abolished phototaxis
DBS0238320cpnA-/ [act15]: GFP: cpnAcpnAdelayed hypotonic response | decreased culmination | delayed development
DBS0235627crlA-/ KAX3crlAdelayed development of tipped mound | abolished polyketide metabolic process | increased mound size | decreased spore germination | decreased spore cell differentiation | decreased cell migration to prestalk region | increased growth rate
DBS0235628crlA-/ [crlA]: crlAcrlAincreased mound size
DBS0235633crtf-crtfabolished sporulation | decreased gene expression | abolished aggregation
DBS0351557cryS-crySdecreased pinocytosis | decreased culmination | decreased phagocytosis | aberrant cytokinesis | decreased growth rate
AX2-T10csaA-csaAdecreased cell-cell adhesion | decreased culmination | abolished protein localization to cell-cell contact zone | delayed aggregation | increased cell-substrate adhesion | decreased sporulation
TL73csaA-/ csbA-/ csbC-/ csbC-csaAincreased stalk width | aberrant late culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbAincreased stalk width | aberrant late culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbBincreased stalk width | aberrant late culminant morphology
TL73csaA-/ csbA-/ csbC-/ csbC-csbCincreased stalk width | aberrant late culminant morphology
TL72csbA-/ csbB-/ csbC-csbAincreased resistance to cisplatin | aberrant cytokinesis | aberrant late culminant morphology
TL72csbA-/ csbB-/ csbC-csbBincreased resistance to cisplatin | aberrant cytokinesis | aberrant late culminant morphology
TL72csbA-/ csbB-/ csbC-csbCincreased resistance to cisplatin | aberrant cytokinesis | aberrant late culminant morphology
WTC127cshA-cshAdevelopment arrests at loose mound stage | decreased phagocytosis | decreased growth rate | delayed aggregation
DBS0235624ctnA-ctnAincreased cGMP-mediated signaling | aberrant cellular metabolic process | increased glucose level | decreased protein level | increased mound size | decreased catalytic activity | increased guanylyl cyclase activity | decreased actin filament polymerization | decreased oscillatory cAMP signaling | increased cell-cell adhesion | increased protein level | increased cell motility | decreased myosin II assembly
DBS0235636ctnB-ctnBincreased number of mounds | decreased gene expression | decreased fruiting body size
DG1071ctr9-ctr9aberrant fruiting body morphogenesis
DG1058ctrA-ctrAdecreased fruiting body size
HS1151ctxA-ctxAaberrant cytokinesis | decreased growth rate | aberrant stream morphology | aberrant cellular response to stress
DBS0349922ctxA-/ [act15]: GFP-mhcActxAaberrant protein localization to basolateral plasma membrane | aberrant stalk morphogenesis | aberrant development of tipped mound
DBS0235599ctxA-/ ctxB-ctxAabolished stream development | aberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | increased lateral pseudopodium formation | aberrant cytokinesis | development arrests at mound stage | aberrant chemotaxis to cAMP | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished aggregation | aberrant regulation of protein kinase activity | increased bleb assembly
DBS0235599ctxA-/ ctxB-ctxBabolished stream development | aberrant cellular response to fluid shear stress | abolished adenylate cyclase activity | increased lateral pseudopodium formation | aberrant cytokinesis | development arrests at mound stage | aberrant chemotaxis to cAMP | decreased cell motility | aberrant regulation of GTPase activity | aberrant cell morphology | abolished aggregation | aberrant regulation of protein kinase activity | increased bleb assembly
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPacaAaberrant fruiting body morphogenesis
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPctxAaberrant fruiting body morphogenesis
DBS0349972ctxA-/ ctxB-/ [act15]: acaA: YFPctxBaberrant fruiting body morphogenesis
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-1abolished stream development | abolished adenylate cyclase activity | development arrests at tight mound stage
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPcarA-2abolished stream development | abolished adenylate cyclase activity | development arrests at tight mound stage
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPctxAabolished stream development | abolished adenylate cyclase activity | development arrests at tight mound stage
DBS0349973ctxA-/ ctxB-/ [act15]: carA: YFPctxBabolished stream development | abolished adenylate cyclase activity | development arrests at tight mound stage
DBS0235600ctxB-ctxBaberrant cytokinesis | aberrant stream morphology | aberrant cell morphology
DBS0350404ctxC-ctxCincreased pinocytosis | decreased oscillatory cAMP signaling | aberrant stream morphology | decreased chemotaxis to cAMP | increased growth rate | increased phagocytosis
DBS0235639cudA-cudAabolished sporulation | decreased gene expression | development arrests at slug stage | decreased prespore gene expression | abolished stalk cell differentiation
DBS0235640culA-culAincreased number of tip-organizers | development arrests at tipped mound stage
DBS0235641culA-/ [cotC]: culAculAincreased sorus size | decreased stalk length | decreased sporulation
DBS0235642culA-/ [ecmA]: culAculAincreased sorus size | decreased stalk length
DBS0266745culB-culBincreased number of mound tips | precocious prestalk gene expression | aberrant slug development | decreased fruiting body size | decreased sporulation
DBS0266761culB-/ [act15]: pkaCculBabolished sporulation | precocious prestalk gene expression | abolished aggregation | abolished prespore gene expression
DBS0266761culB-/ [act15]: pkaCpkaCabolished sporulation | precocious prestalk gene expression | abolished aggregation | abolished prespore gene expression
DBS0266760culB-/ pkaR-culBabolished sporulation | precocious prestalk gene expression | abolished aggregation | abolished prespore gene expression
DBS0266760culB-/ pkaR-pkaRabolished sporulation | precocious prestalk gene expression | abolished aggregation | abolished prespore gene expression
DBS0235651cybA-cybAabolished sporulation | aberrant sorocarp development
DBS0350641cynA-cynAaberrant cell motility | decreased actin filament polymerization | aberrant chemotaxis to cAMP | delayed aggregation | aberrant cell morphology
DBS0351047cytB-cytBdecreased defense response to Gram-negative bacterium | decreased gene expression | development arrests at mound stage | decreased growth rate | aberrant phototaxis
AK108dagA-dagAabolished gene expression | decreased gene expression | abolished activation of adenylate cyclase activity | abolished aggregation | decreased chemotaxis to cAMP
DBS0235653darA-darAdecreased mound size | abolished aggregation
DG1099dcsA-dcsAabolished stalk development | abolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk cell differentiation
DG1128dcsA-dcsAabolished stalk development | abolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis
TL127dcsA-dcsAabolished stalk development | abolished sporulation | aberrant spore coat morphology | abolished cellulose biosynthesis | abolished stalk cell differentiation | aberrant stalk development
DBS0349967dcx-/ lis1(D327H)dcxabolished aggregation
DBS0349967dcx-/ lis1(D327H)lis1abolished aggregation
DBS0349804detA-detAincreased mound size | decreased growth rate | delayed development
DBS0349813detA-/ [cotB]: GFPdetAdecreased prespore cell differentiation
DBS0349811detA-/ [ecm0]: lacZdetAaberrant prestalk O cell differentiation
DBS0349812detA-/ [ecmA0]: GFPdetAincreased prestalk cell differentiation
DBS0349808detA-/ [ecmA0]: lacZdetAincreased prestalk cell differentiation
DBS0349809detA-/ [ecmA]: lacZdetAincreased prestalk A cell differentiation
DBS0349810detA-/ [ecmB]: lacZdetAdelayed development
DBS0350392dgat1-dgat1aberrant cellular metabolic process | abolished lipid droplet formation | increased sporulation
DBS0350393dgat1-/ dgat2-dgat1abolished lipid droplet formation | decreased growth rate | increased sporulation | aberrant endoplasmic reticulum membrane organization
DBS0350393dgat1-/ dgat2-dgat2abolished lipid droplet formation | decreased growth rate | increased sporulation | aberrant endoplasmic reticulum membrane organization
DBS0349911dgcA-dgcAdecreased gene expression | development arrests at slug stage | abolished stalk cell differentiation
DBS0349917dgcA-/ [act15]: dgcA(1-124): YFPdgcAdevelopment arrests at slug stage
DBS0349918dgcA-/ [act15]: dgcA(1-273): YFPdgcAdevelopment arrests at slug stage
DBS0349916dgcA-/ [act15]: dgcA(350-521): YFPdgcAdevelopment arrests at slug stage
DBS0235695dgkA-dgkAdecreased spore germination | increased myosin II assembly | aberrant sorocarp development | decreased chemotaxis rate
AK299dhkA-dhkAaberrant stalk morphogenesis | increased prestalk gene expression | aberrant gene expression | aberrant fruiting body morphogenesis | increased sporulation | abolished response to biotic stimulus | decreased sporulation
DBS0350665dhkA-/ [act15]: dhkA(D2076N)dhkAdecreased sporulation
DBS0350664dhkA-/ [act15]: dhkA(H1396Q)dhkAdecreased sporulation
DBS0235703dhkA-/ [pkaC]: pkaCdhkAaberrant stalk morphogenesis
DBS0235703dhkA-/ [pkaC]: pkaCpkaCaberrant stalk morphogenesis
TL134dhkA-/ dhkB-dhkAabolished sporulation | increased stalk length | decreased stalk width
TL134dhkA-/ dhkB-dhkBabolished sporulation | increased stalk length | decreased stalk width
HR49dhkA-/ fbxA-dhkAaberrant fruiting body morphogenesis | decreased sporulation | decreased cAMP level
HR49dhkA-/ fbxA-fbxAaberrant fruiting body morphogenesis | decreased sporulation | decreased cAMP level
HR51dhkA-/ fbxA-dhkAaberrant fruiting body morphogenesis | decreased sporulation
HR51dhkA-/ fbxA-fbxAaberrant fruiting body morphogenesis | decreased sporulation
HR50dhkA-/ fbxA-dhkAabolished culmination | decreased sporulation
HR50dhkA-/ fbxA-fbxAabolished culmination | decreased sporulation
DBS0350663dhkA-/ pkaR-dhkAdecreased sporulation
DBS0350663dhkA-/ pkaR-pkaRdecreased sporulation
DBS0350662dhkA-/ regA-dhkAdecreased sporulation
DBS0350662dhkA-/ regA-regAdecreased sporulation
DBS0235704dhkB-dhkBprecocious spore germination | decreased cAMP level | aberrant sorus color
TL135dhkC-dhkCprecocious culmination | decreased spore germination | precocious aggregation | precocious development | precocious gene expression
DBS0350379dhkD-dhkDabolished stream development | aberrant slug development | aberrant sorocarp development | precocious gene expression | aberrant late culminant morphology
DBS0350381dhkD-/ [ecmAO]: lacZdhkDaberrant prestalk cell differentiation
DBS0350382dhkD-/ [ecmB]: lacZdhkDaberrant prestalk cell differentiation
DBS0350383dhkD-/ [pspA]: lacZdhkDaberrant prespore cell differentiation
LAS99dhkE-dhkEdecreased socially cooperative development
DBS0351297dhkI-dhkI-1aberrant chemotaxis to cAMP | delayed aggregation
DBS0351297dhkI-dhkI-2aberrant chemotaxis to cAMP | delayed aggregation
DBS0235710dhkK-dhkKaberrant slug migration | delayed culmination | delayed gene expression
DBS0235712dhkK-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphogenesis
DBS0235714dhkK-/ regA-dhkKprecocious development
DBS0235714dhkK-/ regA-regAprecocious development
DBS0348046dhkM-dhkMabolished autophagosome organization | aberrant autophagic cell death
DBS0348047dhkM-dhkMabolished autophagosome organization | abolished actin filament depolymerization | abolished cellulose biosynthesis | abolished autophagic cell death
DBS0350173dhkM-dhkMdecreased autophagic vacuole organization | delayed development
DBS0235719dia1-/ [act6]: trap1dia1aberrant aggregation | decreased fruiting body size
DBS0235719dia1-/ [act6]: trap1trap1aberrant aggregation | decreased fruiting body size
DBS0235895dimA-dimAincreased standing slug length | increased migratory slug size | abolished prestalk cell differentiation | decreased standing slug width | aberrant fruiting body morphogenesis | increased prespore cell differentiation | decreased prestalk O cell differentiation
DBS0235899dimA-/ dimB-dimAincreased migratory slug size | increased standing slug length | aberrant chemotaxis to cAMP | decreased standing slug width
DBS0235899dimA-/ dimB-dimBincreased migratory slug size | increased standing slug length | aberrant chemotaxis to cAMP | decreased standing slug width
DBS0235901dimB-dimBdecreased prestalk B cell differentiation | abolished response to DIF-1 | increased gene expression | aberrant prespore gene expression | aberrant chemotaxis to cAMP
DBS0235902dimB-/ [cotB]: lacZdimBincreased prespore cell differentiation
DBS0235906dimB-/ [ecmAO]: lacZdimBdecreased prestalk O cell differentiation
DBS0235907dimB-/ [ecmO]: lacZdimBaberrant prestalk cell differentiation
DBS0350495dio3-dio3decreased cell-cell adhesion | aberrant aggregation | decreased gene expression | decreased growth rate | decreased prespore cell differentiation | decreased chemotaxis to folate | increased prestalk cell differentiation | decreased cAMP level | decreased phototaxis
DBS0235913dmpA-dmpAaberrant stream morphology | aberrant fruiting body morphogenesis | delayed development | decreased stalk cell differentiation | decreased sporulation | aberrant sorus color
HM1030dmtA-dmtAdelayed development of tipped mound | abolished DIF-1 biosynthesis | decreased outer basal disc size | wild type | abolished prestalk O cell differentiation | decreased standing slug width | decreased lower cup size | decreased prestalk gene expression | aberrant vacuole organization | aberrant fruiting body morphogenesis | delayed development | decreased prestalk O cell differentiation | decreased prestalk cell differentiation
DBS0349975dmtA-/ [dimB]: dimBdimBdecreased prestalk B cell differentiation
DBS0349975dmtA-/ [dimB]: dimBdmtAdecreased prestalk B cell differentiation
HM1196dmtA-/ stlA-dmtAdecreased outer basal disc size | decreased prestalk O cell differentiation
HM1196dmtA-/ stlA-stlBdecreased outer basal disc size | decreased prestalk O cell differentiation
DBS0235915dng1-dng1decreased growth rate | delayed aggregation
DBS0235916dnmA-dnmAdecreased DNA methylation on cytosine | aberrant late culminant morphology | aberrant sorus color | decreased sporulation
DG2015docA-docAdevelopment arrests at mound stage
LAS32docA-docAdecreased socially cooperative development
DBS0350459docD-/ docA-docAaberrant fruiting body morphogenesis | delayed development | decreased chemotaxis to cAMP
DBS0350459docD-/ docA-docDaberrant fruiting body morphogenesis | delayed development | decreased chemotaxis to cAMP
DBS0235920dokA-dokAaberrant hyperosmotic response | aberrant sorus color | decreased sporulation
DBS0349789dotA-dotAaberrant response to UV | decreased growth rate | decreased spore size | delayed development | abolished histone H3-K79 methylation
DBS0351070dspA-dspAdelayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0235925dstA-dstAabolished gene expression | increased gene expression | aberrant prestalk gene expression | abolished cell migration to prestalk region | decreased gene expression | delayed aggregation | decreased prestalk gene expression | decreased cell motility | abolished stalk cell differentiation | aberrant fruiting body morphogenesis
DBS0235926dstA-dstAaberrant prestalk gene expression | abolished cell migration to prestalk region | delayed aggregation | decreased cell motility | abolished stalk cell differentiation | aberrant fruiting body morphogenesis
DBS0238237dstA-/ GFP: dstA(237-707): ORF+dstAabolished culmination | decreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dstAdecreased stalk length
DBS0238236dstA-/ GFP: dstA(237-707): ORF+/ [OE]dutA(751-1322)dutAdecreased stalk length
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2C2Caberrant fruiting body morphogenesis
DBS0252824dstA-/ GFP: dstA(237-707): ORF+/ [act15]: 2CdstAaberrant fruiting body morphogenesis
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165DDB_G0276165aberrant fruiting body morphogenesis
DBS0252826dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0276165dstAaberrant fruiting body morphogenesis
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325DDB_G0282325aberrant fruiting body morphogenesis
DBS0252825dstA-/ GFP: dstA(237-707): ORF+/ [act15]: DDB_G0282325dstAaberrant fruiting body morphogenesis
DBS0235937dtfA-dtfAdelayed development of tipped mound | decreased cell-cell adhesion | aberrant cytokinesis | aberrant cell migration to prestalk region | aberrant fruiting body morphogenesis
DBS0350500dupA-dupAincreased defense response to Gram-negative bacterium | abolished aggregation
DBS0347874dymA-dymAdecreased pinocytosis | aberrant cell separation during cytokinesis | aberrant mitochondrion morphology | decreased phagolysosome size | increased basal disc size | decreased growth rate | aberrant nucleus morphology | increased vegetative cell size | aberrant endosome morphology | aberrant phagosome maturation | delayed development | aberrant stalk development | aberrant fruiting body morphogenesis | decreased establishment of cell polarity | aberrant pseudopodium formation | abolished phagosome acidification | increased phagocytosis | aberrant intracellular distribution of mitochondria
HJW117ecmA-ecmAincreased standing slug length | decreased standing slug width | decreased slime trail
DBS0350904efbA-efbAaberrant cytokinesis | delayed development
DBS0235945egeA-egeAdecreased activation of adenylate cyclase activity | decreased gene expression | abolished aggregation
DBS0350520egeA-/ [unk]: YFP: carAcarA-1development arrests at mound stage
DBS0350520egeA-/ [unk]: YFP: carAcarA-2development arrests at mound stage
DBS0350520egeA-/ [unk]: YFP: carAegeAdevelopment arrests at mound stage
DBS0350521egeA-/ [unk]: pkaCegeAdecreased gene expression | abolished aggregation
DBS0350521egeA-/ [unk]: pkaCpkaCdecreased gene expression | abolished aggregation
DBS0235946egeB-egeBdevelopment arrests at mound stage
DBS0351166ei24-ei24aberrant aggregation | decreased spore germination | increased gene expression | decreased gene expression | decreased growth rate | aberrant cell cycle | delayed development | decreased chemotaxis to cAMP | decreased fruiting body size | decreased cAMP level | decreased sporulation
DBS0302590elmoA-elmoAincreased protein localization to pseudopodium | decreased culmination | abolished establishment of cell polarity | increased actin filament polymerization | decreased cell motility | delayed development | increased pseudopodium formation | increased phagocytosis
DBS0350065elmoE-elmoEdecreased culmination | decreased actin filament polymerization at leading edge | decreased chemotaxis to cAMP
DBS0302448epnA-epnAaberrant spore morphology | decreased spore germination | abolished protein localization to cell cortex | aberrant cytokinesis | abolished protein localization to plasma membrane | aberrant actin cytoskeleton organization | abolished protein phosphorylation
DBS0302457epnA-/ [act15]: GFP: epnA(253-677)epnAaberrant spore morphology | abolished protein localization to plasma membrane | abolished protein localization to clathrin-coated pit
DBS0302474epnA-/ [act15]: epnA(R65A/ K78A): GFPepnAaberrant spore morphology | abolished protein localization to plasma membrane | abolished phosphatidylinositol-4,5-bisphosphate binding | abolished protein localization to clathrin-coated pit | abolished protein phosphorylation
DBS0302475epnA-/ [act15]: epnA(T107A): GFPepnAaberrant spore morphology | abolished protein localization to plasma membrane
DBS0235947eppA-eppAdecreased growth rate | delayed development | decreased chemotaxis to folate | decreased chemotaxis to cAMP | decreased cAMP level
DBS0350028erkA-erkAdecreased mound size | decreased chemotaxis to cAMP
DBS0350622erkA-erkAaberrant development of tipped mound | aberrant stream morphology | abolished protein kinase activation | aberrant cellular response to extracellular stimulus | abolished positive regulation of chemorepellant activity
DBS0350623erkA-erkAdecreased mound size | precocious development
DBS0351474erkA-/ regA-erkAdecreased mound size | aberrant fruiting body morphogenesis
DBS0351474erkA-/ regA-regAdecreased mound size | aberrant fruiting body morphogenesis
HS174erkB-erkBdecreased catalytic activity | aberrant phagocytosis | decreased cell motility | decreased prespore gene expression | decreased prestalk gene expression | aberrant sorocarp development | decreased chemotaxis to folate | abolished aggregation | decreased chemotaxis to cAMP | aberrant cell morphology | decreased sporulation
AK240erkB-erkBabolished aggregation | decreased sporulation
DBS0350606erkB-erkBdecreased prespore cell differentiation
DBS0350683erkB-/ [ecmA]: lacZerkBaberrant cell migration to prestalk region
DBS0350682erkB-/ [unk]: erkB(P140S)erkBabolished sporulation
DBS0235949erkB-/ regA-erkBincreased oscillatory cAMP signaling | abolished aggregation
DBS0235949erkB-/ regA-regAincreased oscillatory cAMP signaling | abolished aggregation
DBS0350240fam21-fam21abolished exocytosis | aberrant vegetative growth | decreased protein localization to post-lysosomal vacuole | decreased protein processing in phagocytic vesicle | aberrant autophagic cell death | aberrant phagosome maturation | aberrant lysosome organization
DBS0235953fbxA-fbxAdecreased sporulation
HR6fbxA-fbxAdecreased socially cooperative development
HR42fbxA-/ [act15]: myc: fbxAfbxAabolished culmination | decreased sporulation
DBS0235954fbxA-/ [ecmA]: GFP(S65T)fbxAincreased prespore cell differentiation
HR46fbxA-/ regA-fbxAaberrant fruiting body morphogenesis | decreased sporulation
HR46fbxA-/ regA-regAaberrant fruiting body morphogenesis | decreased sporulation
HR48fbxA-/ regA-fbxAaberrant fruiting body morphogenesis | decreased sporulation
HR48fbxA-/ regA-regAaberrant fruiting body morphogenesis | decreased sporulation
DBS0235956fbxA1-fbxAdevelopment arrests at slug stage | aberrant fruiting body morphogenesis | increased slug migration | delayed culmination
DBS0235957fbxA2-fbxAdevelopment arrests at slug stage | aberrant fruiting body morphogenesis | increased slug migration | delayed culmination
DBS0235958fbxA3-fbxAdevelopment arrests at slug stage | aberrant fruiting body morphogenesis | increased slug migration | delayed culmination
DG1148fcpA-fcpAaberrant fruiting body morphogenesis
DBS0235960fcsA-fcsAdecreased fatty acid level | decreased lipid droplet formation | increased sporulation
DBS0350129fcsB-/ fcsA-fcsAdecreased catalytic activity | decreased growth rate | delayed development
DBS0350129fcsB-/ fcsA-fcsBdecreased catalytic activity | decreased growth rate | delayed development
DBS0235969forC-forCaberrant culmination | aberrant fruiting body morphogenesis | development arrests at tipped mound stage
DBS0350280forC-forCdelayed aggregation | aberrant sorocarp development | decreased chemotaxis to cAMP | decreased sporulation | abolished slug development | delayed gene expression
DBS0350287forF-forFdecreased fruiting body size | aberrant phototaxis | increased chemotaxis rate
HW440fpaA(P143A)fpaAdelayed aggregation | increased response to hypoxia
HW435fpaB-/ AX2fpaB-1decreased response to hypoxia | increased culmination | increased stalk length
HW435fpaB-/ AX2fpaB-2decreased response to hypoxia | increased culmination | increased stalk length
DBS0302506frmA-frmAdelayed aggregation | decreased cell motility | decreased mound size | increased cell-substrate adhesion | aberrant cell morphology
DBS0304440frmA-/ [unk]: GFPfrmAdecreased gene expression | aberrant sorocarp development | increased cell-cell adhesion | delayed development | abolished phototaxis
DBS0350983frmB-frmBaberrant aggregation | increased mound size | decreased cell-substrate adhesion | increased fruiting body size
DG1066fut1-fut1aberrant fruiting body morphogenesis
DBS0305025gabT-gabTprecocious development | decreased sporulation
DG1094gacT-gacTaberrant fruiting body morphogenesis
DBS0235989gadA-gadAdecreased spore cell differentiation | decreased sporulation
DBS0350071gadA-gadAdecreased spore germination
DBS0350077gadA-/ gadB-gadAdelayed aggregation
DBS0350077gadA-/ gadB-gadBdelayed aggregation
DBS0350072gadB-gadBdelayed aggregation
TL198gbfA-gbfAabolished gene expression | development arrests at mound stage
DBS0305094gbfA-gbfAabolished autophagosome organization | abolished autophagic cell death
DBS0235994gbpC-gbpCdecreased protein kinase activation | decreased fruiting body size
DBS0235995gbpC-gbpCaberrant chemotaxis to cAMP | aberrant myosin II filament organization | decreased chemotaxis rate | aberrant cyclic nucleotide binding | aberrant cell morphology | decreased establishment of cell polarity | decreased fruiting body size
DBS0302680gbpC-gbpCabolished protein localization to nucleus | decreased mound size | abolished protein phosphorylation
DBS0349868gbpC-/ [act15]: gbpC(1-2331: 2470-2631): GFPgbpCaberrant stream morphology | decreased chemotaxis to cAMP
DBS0235996gbpC-/ gbpD-gbpCdelayed aggregation | decreased chemotaxis rate | decreased establishment of cell polarity | increased bleb assembly
DBS0235996gbpC-/ gbpD-gbpDdelayed aggregation | decreased chemotaxis rate | decreased establishment of cell polarity | increased bleb assembly
DBS0235998gbpD-/ [act15]: gbpDgbpDincreased lateral pseudopodium formation | increased cell-substrate adhesion | decreased chemotaxis rate | aberrant actin filament organization | abolished aggregation
DG1120gbqA-gbqAaberrant fruiting body morphogenesis
DBS0302679gca-/ sgcA-gcAincreased lateral pseudopodium formation | aberrant activation of GTPase activity | aberrant chemotaxis to cAMP | aberrant taxis | aberrant stream morphology | decreased mound size | decreased chemotaxis rate | decreased fruiting body size
DBS0302679gca-/ sgcA-sgcAincreased lateral pseudopodium formation | aberrant activation of GTPase activity | aberrant chemotaxis to cAMP | aberrant taxis | aberrant stream morphology | decreased mound size | decreased chemotaxis rate | decreased fruiting body size
DBS0236002gcsA-gcsAabolished sporulation | aberrant cellular metabolic process | decreased gene expression | increased gene expression | development arrests at mound stage | abolished vegetative growth | mitotic G1 phase arrest | abolished aggregation | abolished prespore gene expression
DBS0350387gcsA-/ [act15]: carAcarA-1abolished aggregation
DBS0350387gcsA-/ [act15]: carAcarA-2abolished aggregation
DBS0350387gcsA-/ [act15]: carAgcsAabolished aggregation
DBS0236003gcsA-/ [act15]: gcsAgcsAdecreased spore germination | development arrests at mound stage
DBS0236004gdt1-gdt1increased gene expression | decreased growth rate | precocious aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)gdt1increased gene expression | abolished aggregation
DBS0237190gdt1-/ [act15]: pkaR(G135E/ G261A)pkaRincreased gene expression | abolished aggregation
DBS0236095gdt1-/ gpaB-gdt1increased gene expression | abolished aggregation
DBS0236095gdt1-/ gpaB-gpaBincreased gene expression | abolished aggregation
DBS0236006gdt2-gdt2increased gene expression | precocious aggregation
RI19gefA-gefAdecreased actin filament polymerization | decreased gene expression | decreased activation of GTPase activity | abolished activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased chemotaxis rate | abolished aggregation | increased protein kinase activation
JB10gefA-gefAabolished aggregation
DBS0350821gefA-gefAdecreased actin filament polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | decreased protein kinase activation | abolished aggregation
DBS0236009gefB-/ AX3gefBabolished pinocytosis | delayed aggregation | increased actin filament polymerization | decreased phagocytosis | decreased growth rate | decreased mound size | abolished vegetative growth | aberrant fruiting body morphogenesis | aberrant cell morphology | increased bleb assembly | aberrant cytoskeleton organization
DBS0350569gefE-gefEdecreased activation of GTPase activity | increased gene expression | decreased response to DIF-1 | increased prespore cell differentiation
DBS0350822gefH-gefHdecreased actin filament polymerization | decreased activation of GTPase activity | aberrant chemotaxis to cAMP | delayed development | decreased protein kinase activation
DBS0350823gefH-/ gefA-gefAdecreased actin filament polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0350823gefH-/ gefA-gefHdecreased actin filament polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
HSB61gefM-gefMincreased cGMP-mediated signaling | decreased lateral pseudopodium retraction | aberrant activation of adenylate cyclase activity | development arrests at mound stage | decreased chemotaxis rate
DBS0304968gefQ-gefQdecreased positive regulation of GTPase activity | increased number of mound tips | increased myosin II assembly | increased lateral pseudopodium formation | abolished cell migration to prestalk region | abolished guanyl-nucleotide exchange factor activity | decreased growth rate | decreased fruiting body size | abolished phototaxis
DBS0350811gflB-gflBdecreased culmination | decreased protein localization to cell cortex | aberrant G protein-coupled receptor signaling | delayed aggregation | decreased mound size | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | increased actin filament polymerization at leading edge | decreased myosin II assembly
DG1109ggtA-ggtAaberrant fruiting body morphogenesis
DBS0266723glcS-/ DH1glcSaberrant stalk morphogenesis | decreased glycogen level | decreased spore size | decreased fruiting body size
DBS0351101glkA-glkAaberrant aggregation | decreased protein localization to cell cortex | decreased protein level | decreased chemotaxis to cAMP | decreased myosin II assembly | increased activation of GTPase activity | increased protein kinase activation
HL250gmd(G108D)gmddecreased spore germination | decreased growth rate
DBS0236079gmsA-gmsAdecreased sexual fusion
DBS0236080gmsA-gmsAdecreased sexual fusion
HW503gnt1(1-253/ H104D)gnt1aberrant stalk morphogenesis | development arrests at slug stage | increased response to hypoxia
DBS0238382gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0238383gnt15-gnt15decreased gene expression | decreased growth rate | increased calcium-independent cell-cell adhesion | abolished aggregation | abolished culmination
DBS0235414gp130-gp130decreased response to Gram-positive bacterium | decreased cell-substrate adhesion | delayed development | increased growth rate
DBS0236087gpaA-gpaAaberrant aggregation | increased stalk length | aberrant response to cAMP | decreased stalk width
DBS0236092gpaA-/ [gpaA]: gpaA(G45V)gpaAdelayed development
DBS0236093gpaA-/ [gpaA]: gpaA(Q206L)gpaAincreased basal disc size
DBS0238605gpaA-/ rpkA-gpaAdelayed aggregation | abolished aggregation
DBS0238605gpaA-/ rpkA-rpkAdelayed aggregation | abolished aggregation
DBS0236575gpaB-gpaBdecreased response to cAMP | abolished activation of GTPase activity | aberrant phagocytosis | decreased cGMP-mediated signaling | decreased protein kinase activation | abolished aggregation | abolished chemotaxis to cAMP
JH104gpaB-gpaBdecreased gene expression | decreased activation of GTPase activity | abolished activation of adenylate cyclase activity | abolished aggregation | abolished chemotaxis to cAMP
DBS0236096gpaB-/ [act15]: gpaBgpaBabolished aggregation
DBS0266942gpaB-/ [act15]: gpaBgpaBdelayed aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaBabolished aggregation
DBS0266939gpaB-/ [act15]: gpaB(1-345): gpaD(337-345)gpaDabolished aggregation
DBS0351103gpaB-/ [act15]: gpaB(C4A)gpaBabolished protein localization to plasma membrane | decreased cGMP-mediated signaling | abolished aggregation
DBS0237137gpaB-/ [act15]: gpaB(D154V)gpaBaberrant aggregation | decreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased oscillatory cAMP signaling | decreased chemotaxis rate
DBS0237138gpaB-/ [act15]: gpaB(E190G)gpaBaberrant aggregation | decreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased oscillatory cAMP signaling
DBS0237139gpaB-/ [act15]: gpaB(I104S)gpaBaberrant aggregation | decreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased oscillatory cAMP signaling | decreased chemotaxis rate
DBS0237140gpaB-/ [act15]: gpaB(L110S)gpaBaberrant aggregation | decreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased oscillatory cAMP signaling | decreased chemotaxis rate
DBS0237141gpaB-/ [act15]: gpaB(L76P)gpaBabolished aggregation
DBS0237142gpaB-/ [act15]: gpaB(N74D)gpaBdecreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased oscillatory cAMP signaling | decreased chemotaxis rate | abolished aggregation
DBS0237143gpaB-/ [act15]: gpaB(R64G)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0237144gpaB-/ [act15]: gpaB(S155P)gpaBdecreased chemotaxis rate | abolished aggregation
DBS0351267gpaB-/ [act15]: gpbA: YFPgpaBabolished aggregation
DBS0351267gpaB-/ [act15]: gpbA: YFPgpbAabolished aggregation
DBS0236097gpaB-/ [gpaA]: gpaBgpaBabolished aggregation
DBS0350373gpaB-/ regA-gpaBdecreased number of mounds
DBS0350373gpaB-/ regA-regAdecreased number of mounds
DBS0235986gpaC-gpaCaberrant activation of adenylate cyclase activity | decreased gene expression | increased protein kinase activity | abolished aggregation
JH417gpaD-gpaDdecreased gene expression | aberrant macropinocytosis | decreased spore cell differentiation | aberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased protein kinase activation | abolished protein phosphorylation | decreased cGMP biosynthesis | decreased sporulation
DBS0266944gpaD-/ [act15]: gpaBgpaBaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0266944gpaD-/ [act15]: gpaBgpaDaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaBaberrant fruiting body morphogenesis | decreased cGMP biosynthesis
DBS0266946gpaD-/ [act15]: gpaB(1-345): gpaD(337-345)gpaDaberrant fruiting body morphogenesis | decreased cGMP biosynthesis
DBS0350608gpaD-/ [act15]: gpaD(Q200L)gpaDdevelopment arrests at loose mound stage | decreased chemotaxis to folate | decreased protein kinase activation
DBS0350607gpaD-/ [act15]: gpaD(R107E,R108E)gpaDdevelopment arrests at slug stage | aberrant slug development
DBS0266945gpaD-/ [act15]: gpaEgpaDaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0266945gpaD-/ [act15]: gpaEgpaEaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaDaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0266947gpaD-/ [act15]: gpaE(1-339): gpaD(337-345)gpaEaberrant fruiting body morphogenesis | decreased chemotaxis to folate | decreased cGMP biosynthesis
DBS0350374gpaD-/ regA-gpaDaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350374gpaD-/ regA-regAaberrant aggregation | abolished slug migration | decreased sporulation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZgpaDincreased prestalk O cell differentiation
DBS0350378gpaD-/ regA-/ [ecmB]: lacZregAincreased prestalk O cell differentiation
JH257gpaE-gpaEdelayed development of tipped mound | increased chemotaxis to folate | delayed prestalk gene expression | increased vegetative cell size | delayed prespore gene expression | decreased cell migration to prestalk region
DBS0266941gpaE-/ [act15]: gpaEgpaEprecocious development of tipped mound
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaDprecocious development of tipped mound
DBS0266948gpaE-/ [act15]: gpaE(1-339): gpaD(337-345)gpaEprecocious development of tipped mound
DBS0350678gpaE-/ [act15]: gpaE(K10E/ K11E)gpaEdelayed development of tipped mound | delayed gene expression
DBS0350624gpaE-/ erkA-erkAwild type | decreased mound size | precocious development
DBS0350624gpaE-/ erkA-gpaEwild type | decreased mound size | precocious development
LW1gpaG-gpaGwild type | decreased spore cell differentiation | aberrant GABA signaling pathway
DBS0236107gpaH-gpaHwild type | increased cell death | decreased spore germination | abolished negative chemotaxis | increased growth rate | abolished positive regulation of chemorepellant activity | decreased sporulation
DBS0350975gpaH-/ [ecmO]: lacZgpaHaberrant cell differentiation
DBS0236109gpaI-gpaIincreased number of mounds | aberrant cellular homeostasis | increased establishment of cell polarity | increased cell death | aberrant activation of adenylate cyclase activity | increased chemotaxis to cAMP | precocious aggregation | increased actin filament polymerization | aberrant adaptation of signaling pathway | decreased mound size | decreased oscillatory cAMP signaling | decreased lateral pseudopodium formation | decreased fruiting body size | increased growth rate | aberrant protein localization to plasma membrane | increased cGMP biosynthesis
DBS0351544gpat-gpataberrant lipid storage | decreased lipid droplet formation | increased sporulation | increased phagocytosis
LW5gpbA-gpbAaberrant taxis | increased resistance to N-Phenylthiourea | abolished aggregation
LW6gpbA-gpbAdecreased protein localization to plasma membrane | aberrant cellular homeostasis | aberrant extracellular cAMP signaling pathway | decreased positive regulation of GTPase activity | increased cell death | abolished chemotaxis to folate | aberrant phagocytosis | aberrant chemotaxis | abolished activation of adenylate cyclase activity | decreased cGMP-mediated signaling | decreased engulfment during phagocytosis | aberrant sorocarp development | decreased chemotaxis to folate | decreased protein kinase activation | decreased chemotaxis to cAMP | abolished actin filament polymerization | increased growth rate | aberrant protein localization | aberrant signal transduction
LW14gpbA-/ [act15]: carAcarA-1aberrant calcium-mediated signaling | decreased protein kinase activation | abolished aggregation
LW14gpbA-/ [act15]: carAcarA-2aberrant calcium-mediated signaling | decreased protein kinase activation | abolished aggregation
LW14gpbA-/ [act15]: carAgpbAaberrant calcium-mediated signaling | decreased protein kinase activation | abolished aggregation
LW17gpbA-/ [act15]: carCcarCabolished aggregation
LW17gpbA-/ [act15]: carCgpbAabolished aggregation
DBS0351260gpbA-/ [act15]: gpbA(A99T/ Y271H/ C335M)gpbAabolished activation of adenylate cyclase activity | aberrant fruiting body morphogenesis
DBS0351261gpbA-/ [act15]: gpbA(M30V/ K85R/ S104P/ Q163H)gpbAdevelopment arrests at mound stage | abolished activation of adenylate cyclase activity | decreased chemotaxis to cAMP
DBS0351263gpbA-/ [act15]: gpbA(M48T/ I52T/ E310G)gpbAwild type | decreased activation of adenylate cyclase activity | decreased gene expression | aberrant slug development
DBS0351259gpbA-/ [act15]: gpbA(N147D/ H149R/ N237S)gpbAdevelopment arrests at mound stage | abolished activation of adenylate cyclase activity | abolished chemotaxis to cAMP
DBS0351264gpbA-/ [act15]: gpbA(R13G/ N74S/ S79P/ H149R/ V178A/ V194R/ F293L)gpbAdecreased activation of adenylate cyclase activity | decreased gene expression | development arrests at tipped mound stage
DBS0351262gpbA-/ [act15]: gpbA(S196G/ V199D/ C211R)gpbAdecreased activation of adenylate cyclase activity | aberrant fruiting body morphogenesis
DBS0351258gpbA-/ [act15]: gpbA(V88A/ F229S/ D235V)gpbAabolished activation of adenylate cyclase activity | aberrant fruiting body morphogenesis | decreased chemotaxis to cAMP
DBS0350477gpr89-gpr89aberrant spore morphology | aberrant mitochondrion morphology | abolished cell migration to prestalk region | decreased gene expression | aberrant slug development | abolished vegetative growth | decreased cell motility | decreased fruiting body size | precocious gene expression | decreased phototaxis | delayed gene expression
DBS0304814grlA-grlAdelayed prestalk gene expression | decreased prestalk gene expression | decreased spore cell differentiation | decreased sporulation | delayed culmination
DBS0304815grlA-/ [act15]: grlA: GFPgrlAaberrant development of tipped mound
DBS0350074grlB-grlBdecreased small molecule binding | aberrant positive regulation of chemorepellant activity | delayed aggregation | aberrant vegetative growth | delayed gene expression
DBS0350078grlB-/ grlE-grlBdecreased small molecule binding | delayed aggregation
DBS0350078grlB-/ grlE-grlEdecreased small molecule binding | delayed aggregation
DBS0236112grlE-grlEdecreased spore cell differentiation | aberrant GABA signaling pathway | decreased sporulation
DBS0236113grlE-grlEdelayed aggregation | aberrant gene expression | decreased chemotaxis to cAMP
DBS0350075grlE-grlEdecreased spore germination | delayed aggregation
DBS0238865grlJ-grlJincreased migratory slug size | aberrant spore morphology | decreased spore germination | precocious development | decreased fruiting body size | precocious gene expression
DBS0350283grlJ-grlJaberrant spore morphology | increased resistance to N-Phenylthiourea
DBS0238686grpA-grpAdecreased spore germination | abolished protein secretion
ARK200gskA-gskAabolished stream development | increased gene expression | decreased gene expression | increased protein localization to plasma membrane | decreased chemotaxis to cAMP | decreased sporulation
DBS0236114gskA-gskAaberrant aggregation | decreased protein localization to cell cortex | decreased slug migration | aberrant sorus morphology | aberrant extracellular cAMP signaling pathway | decreased gene expression | abolished protein localization to plasma membrane | abolished protein phosphorylation | decreased chemotaxis to folate | decreased stalk length | abolished chemotaxis to cAMP
HM338gskA-gskAprecocious aggregation | decreased prespore cell differentiation | aberrant mitotic spindle elongation | aberrant fruiting body morphogenesis | increased prestalk cell differentiation | decreased sporulation
DBS0349881gskA-/ [act15]: gskA(Y214F)gskAabolished stream development
DBS0350427gskA-/ gskA(K85R): GFPgskAaberrant aggregation
DBS0350988gst4-gst4decreased fruiting body size
DBS0266891gtaC-gtaCdecreased mound size | aberrant stream morphology | abolished stalk cell differentiation | aberrant prestalk B cell differentiation
DBS0350347gtaC-gtaCabolished gene expression | decreased fruiting body size | abolished aggregation
DBS0350357gtaC-/ [act15]: GFP: gtaC(C500,503,522,525S)gtaCaberrant gene expression | abolished aggregation | decreased fruiting body size
DBS0350361gtaC-/ [act15]: gtaC: (468-496): GFP: gtaCgtaCdevelopment arrests at mound stage | decreased mound size | precocious development
DBS0266892gtaC-KDgtaCabolished stalk cell differentiation
DBS0351091gtaG-gtaGdecreased gene expression | development arrests at slug stage | aberrant slug development | decreased prestalk A cell differentiation | decreased sporulation
DBS0236120gxcA-gxcAdecreased activation of GTPase activity | decreased actin filament polymerization | delayed development
DBS0236121gxcB-gxcBdecreased exocytosis | delayed development | aberrant cytoskeleton organization
DBS0350256gxcC-gxcCdelayed development
DBS0238825gxcDD-gxcDDaberrant stream morphology | delayed development
LAS105gxcKK-gxcKKdecreased socially cooperative development
DBS0350268gxcT-gxcTaberrant activation of GTPase activity | increased lateral pseudopodium formation | aberrant cytokinesis | decreased growth rate | delayed aggregation | decreased establishment of cell polarity | decreased chemotaxis to cAMP | decreased fruiting body size | aberrant protein localization to plasma membrane
DBS0236131hbx2-/ warA-hbx2increased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0236131hbx2-/ warA-warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0350324hbx4-/ [ecmAO]: lacZhbx4increased prespore cell differentiation
DBS0350879hbx9-hbx9decreased cell-cell adhesion | decreased gene expression | delayed aggregation | decreased growth rate | decreased chemotaxis to cAMP
DBS0350880hbx9-/ [ecmA]: lacZhbx9increased prestalk A cell differentiation
DBS0305109hdaB-hdaBdecreased sporulation | decreased histone deacetylase activity
HM1012helC-helCdecreased gene expression | delayed development | aberrant fruiting body morphogenesis
HM444helC-helCdecreased gene expression | aberrant fruiting body morphogenesis | delayed development
DG1059helE-helEincreased slug migration
DBS0236163helF-helFincreased migratory slug size | increased stalk cell differentiation | delayed development | increased post-transciptional gene silencing by RNA
DBS0350878hephA-hephAincreased response to cAMP | delayed aggregation | aberrant sorocarp development | decreased cAMP level
DBS0350362hfnA-hfnAincreased phototaxis | decreased migratory slug size | increased slug migration
DBS0350363hfnA-/ [ecmO]: lacZhfnAaberrant slug development | aberrant prestalk O cell differentiation
DBS0350364hfnA-/ abpC-abpCwild type | aberrant prestalk O cell differentiation | decreased phototaxis
DBS0350364hfnA-/ abpC-hfnAwild type | aberrant prestalk O cell differentiation | decreased phototaxis
DBS0351593hgrA-hgrAaberrant macrocyst formation
DBS0351593hgrA-matAaberrant macrocyst formation
DBS0351590hgrA-/ KAX3hgrAaberrant macrocyst formation
DBS0351594hgrB-hgrBaberrant macrocyst formation
DBS0351594hgrB-matAaberrant macrocyst formation
DBS0351591hgrB-/ KAX3hgrBaberrant macrocyst formation
DBS0238583hipA-hipAdecreased spore germination | aberrant spore morphology | aberrant cortical actin cytoskeleton organization | aberrant spore coat morphology | increased protein localization to plasma membrane
DBS0305951hipA-/ epnA-epnAdecreased spore germination | aberrant spore morphology
DBS0305951hipA-/ epnA-hipAdecreased spore germination | aberrant spore morphology
DBS0349776htt-httaberrant cell separation during cytokinesis | decreased growth rate | decreased chemotaxis rate | delayed development | delayed gene expression | decreased myosin II assembly
DBS0349788htt-httaberrant aggregation | abolished stream development | development arrests at loose mound stage | aberrant cellular response to starvation | aberrant spore morphology | decreased spore germination | abolished cell motility in response to calcium ion | increased number of mound tips | aberrant sorocarp development | aberrant hypotonic response | aberrant actin filament organization | abolished culmination | decreased sporulation | aberrant prespore cell differentiation | abolished calcium-independent cell-cell adhesion | abolished protein level | abolished chemotaxis to cAMP
DBS0351281htt-httabolished gene expression | aberrant sorus morphology | decreased gene expression | decreased growth rate | aberrant slug development | aberrant sorocarp development | delayed development | decreased cAMP level | aberrant prestalk cell differentiation
DBS0349794ibrA-ibrAaberrant stalk development
DBS0252699icmA-icmA-1abolished sporulation | abolished stream development | aberrant extracellular cAMP signaling pathway | abolished establishment of cell polarity | development arrests at mound stage | abolished vegetative growth | aberrant oscillatory cAMP signaling | aberrant fruiting body morphogenesis | aberrant protein localization to nucleus | delayed gene expression | aberrant protein localization
DBS0252699icmA-icmA-2abolished sporulation | abolished stream development | aberrant extracellular cAMP signaling pathway | abolished establishment of cell polarity | development arrests at mound stage | abolished vegetative growth | aberrant oscillatory cAMP signaling | aberrant fruiting body morphogenesis | aberrant protein localization to nucleus | delayed gene expression | aberrant protein localization
BS153ifkA-ifkAincreased mound size | precocious aggregation | precocious gene expression | decreased protein secretion
BS161ifkA-/ ifkB-ifkAincreased mound size | increased number of mound tips | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphogenesis
BS161ifkA-/ ifkB-ifkBincreased mound size | increased number of mound tips | increased cell-cell adhesion | increased cell-substrate adhesion | aberrant fruiting body morphogenesis
DBS0236425ino1-ino1increased number of mound tips | decreased phagocytosis | abolished vegetative growth | increased 2,3-bisphosphoglycerate level | decreased myo-inositol level
DBS0350801ino1-ino1aberrant cellular metabolic process | increased number of autophagosomes | decreased cell-substrate adhesion | aberrant phosphatidylinositol metabolism | aberrant cytokinesis | abolished vegetative growth | aberrant fruiting body morphogenesis | decreased myo-inositol level
DBS0266326iplA-iplAabolished cellulose biosynthesis | abolished autophagosome organization | abolished autophagic cell death | aberrant autophagic cell death
HM1038iplA-iplAaberrant cell motility | precocious aggregation | delayed aggregation | aberrant chemotaxis | aberrant calcium-mediated signaling | increased bleb assembly | increased chemotaxis to arachidonic acid | abolished positive regulation of chemorepellant activity
DBS0252878iptA-iptAdecreased spore germination | aberrant sporulation
DBS0350057keaA-keaAaberrant extracellular cAMP signaling pathway | decreased gene expression | delayed aggregation | decreased growth rate | decreased cAMP level
DBS0236494kif7-kif7decreased cell migration to prestalk region
DBS0351502knkA-knkAdecreased spore germination | aberrant spore morphology | decreased number of autophagosomes | decreased prespore gene expression | aberrant fruiting body morphogenesis | aberrant phototaxis | decreased sporulation
DBS0238720krsA-krsAabolished stream development | precocious culmination | abolished activation of adenylate cyclase activity | decreased vegetative cell size | decreased mound size | aberrant hyperosmotic response | precocious gene expression | decreased cAMP level
DBS0238722krsA-/ [act15]: GFP: krsA(K49R)krsAaberrant stream morphology
DBS0238723krsA-/ [act15]: GFP: krsA(T173A)krsAabolished stream development
DBS0238725krsA-/ [act15]: GFP: krsA(deltaC)krsAaberrant stream morphology
DBS0238724krsA-/ [act15]: GFP: krsA(deltaKinase)krsAabolished stream development
DBS0238726krsA-/ [act15]: GFP: krsA(deltaNS)krsAabolished stream development
DBS0350598krsB-krsBaberrant stream morphology | decreased cell motility | increased cell-substrate adhesion | delayed development | decreased chemotaxis to cAMP
DBS0350599krsB-/ [tet]: krsB(T176A): GFPkrsBaberrant stream morphology
DBS0350600krsB-/ krsA-krsAaberrant stream morphology | delayed development
DBS0350600krsB-/ krsA-krsBaberrant stream morphology | delayed development
DBS0236498lagD-tgrD1aberrant aggregation | abolished stream development | aberrant extracellular cAMP signaling pathway
DBS0236499limB-limBdecreased cell-substrate adhesion | abolished cell migration to prestalk region | development arrests at mound stage | delayed prestalk gene expression | aberrant cell-cell adhesion | decreased prestalk gene expression | decreased chemotaxis rate | aberrant actin filament organization | decreased establishment of cell polarity
DBS0236502limB-/ [act15]: paxB: GFPlimBdevelopment arrests at mound stage
DBS0236502limB-/ [act15]: paxB: GFPpaxBdevelopment arrests at mound stage
DBS0236500limB-/ [cotC]: limBlimBdevelopment arrests at mound stage
DBS0236729limB-/ paxB-limBdevelopment arrests at mound stage
DBS0236729limB-/ paxB-paxBdevelopment arrests at mound stage
DBS0350563limC-limCdelayed aggregation | decreased growth rate | aberrant cytokinesis | aberrant response to osmotic stress
DBS0350564limD1-limD1increased lateral pseudopodium formation | delayed aggregation | decreased growth rate | aberrant cytokinesis | aberrant response to osmotic stress | decreased chemotaxis to cAMP | decreased establishment of cell polarity | aberrant actin filament organization
DBS0350565limD1-/ limC-limCdelayed aggregation | aberrant cytokinesis | abolished vegetative growth | aberrant response to osmotic stress | decreased chemotaxis to cAMP | aberrant actin filament organization | decreased establishment of cell polarity
DBS0350565limD1-/ limC-limD1delayed aggregation | aberrant cytokinesis | abolished vegetative growth | aberrant response to osmotic stress | decreased chemotaxis to cAMP | aberrant actin filament organization | decreased establishment of cell polarity
DG1006lipA-lipAabolished culmination
DG1056lipB-captCaberrant fruiting body morphogenesis
DBS0349950lmbd2B-lmbd2Baberrant chemotaxis | delayed development | aberrant cell morphology | increased pseudopodium formation
DBS0350354lmpA-lmpAdecreased lysosomal protein degradation | decreased pinocytosis | decreased protein level | decreased phagocytosis | decreased growth rate | decreased cell motility | decreased protein processing in phagocytic vesicle | aberrant phagosome maturation | decreased fruiting body size | decreased defense response to Gram-positive bacterium | decreased sporulation
DBS0236516lrrA-lrrAincreased mound size | decreased spore germination | decreased cell-substrate adhesion | abolished establishment of cell polarity | decreased gene expression | development arrests at mound stage | increased actin filament polymerization | abolished positive chemotaxis | abolished aggregation | delayed gene expression
DBS0350407lrrB-lrrBaberrant thermotaxis | delayed slug development | aberrant gene expression | aberrant sorocarp development | decreased prestalk gene expression | aberrant phototaxis | aberrant late culminant morphology
DBS0350478lrrB-/ [ecmB]: lacZlrrBaberrant prestalk B cell differentiation
DBS0350476lrrB-/ [ecmO]: lacZlrrBaberrant prestalk O cell differentiation
DBS0236517lst8-lst8aberrant activation of adenylate cyclase activity | decreased actin filament polymerization | decreased chemotaxis rate | abolished aggregation | decreased myosin II assembly | abolished positive regulation of chemorepellant activity
DBS0349933macA-macAaberrant macrocyst formation | decreased sexual fusion
DBS0351251matA-matAabolished mating type determination
HM1524matA-matAabolished mating type determination
DBS0350211mef2A-mef2Adecreased growth rate | aberrant sorocarp development | aberrant stream morphology | decreased sporulation
DBS0350212mef2A-mef2Adecreased growth rate | aberrant stream morphology | aberrant sorocarp development | aberrant gene expression | decreased sporulation
DBS0350213mef2A-/ [ecmA]: lacZmef2Aaberrant prestalk A cell differentiation
DBS0350214mef2A-/ [ecmB]: lacZmef2Aaberrant prestalk B cell differentiation
DBS0350215mef2A-/ [pspA]: lacZmef2Adecreased prespore cell differentiation
DBS0236543mekA-mekAdecreased mound size | precocious development | abolished chemotaxis to cAMP
DBS0350036mekA-/ [act15]: mekA(299-360)mekAdecreased mound size
DBS0350035mekA-/ [act15]: mekA(K321A)mekAdecreased mound size
DBS0350032mekA-/ [act15]: mekA(S444A/ T448A)mekAdecreased mound size
DBS0350031mekA-/ [act15]: mekA(S444E/ T448E)mekAdevelopment arrests at mound stage
DBS0238098mekA-/ ppp4C-mekAdecreased mound size
DBS0238098mekA-/ ppp4C-ppp4cdecreased mound size
DBS0238109mekA-/ ppp4C-/ [act15]: FLAG: pppCppp4cdecreased mound size | precocious development
DBS0236542mekA-/ smkA-mekAdecreased mound size
DBS0236542mekA-/ smkA-smkAdecreased mound size
DBS0236544mfeA-mfeAaberrant cellular metabolic process | decreased protein level | aberrant extracellular cAMP signaling pathway | development arrests at mound stage
DBS0266843mgp1-mgp1increased phototaxis | abolished stream development | increased filopodium formation | aberrant contractile vacuole organization | decreased cell motility | decreased fruiting body size | decreased stalk width | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp1increased filopodium formation | aberrant contractile vacuole organization | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266846mgp1-/ mgp2-mgp2increased filopodium formation | aberrant contractile vacuole organization | aberrant culmination | decreased cell motility | decreased phototaxis | decreased stalk length
DBS0266844mgp2-mgp2increased migratory slug size | increased mound size
HS1mhcA-mhcAdevelopment arrests at mound stage | aberrant cytokinesis | decreased growth rate | increased actin filament polymerization | aberrant hypotonic response | aberrant regulation of GTPase activity | abolished bleb assembly | aberrant regulation of protein kinase activity | aberrant cellular response to stress
HS2207mhcA-mhcAabolished cytokinesis | development arrests at mound stage
HK323mhcA-mhcAdecreased cell motility | aberrant stream morphology
DBS0350808mhcA-/ [act15]: mhcA(1-933: 1455-2116]mhcAwild type | aberrant cytokinesis | aberrant fruiting body morphogenesis
DBS0238158mhcA-/ [act15]: mhcA(81-2116)mhcAdecreased growth rate | development arrests at tipped mound stage
DBS0236552mhcA-/ [mhcA]: mhcA(1-1224)mhcAaberrant cytokinesis | development arrests at mound stage
DBS0236557mhkA-/ [act15]: mhkAmhkAdecreased growth rate | development arrests at mound stage | aberrant cytokinesis | decreased myosin II assembly
DG1069mhkC-mhkCaberrant fruiting body morphogenesis
DBS0236559midA-midAdecreased pinocytosis | aberrant cellular homeostasis | aberrant spore morphology | decreased glycogen level | increased ammonia level | decreased thermotaxis | increased autophagy | decreased mitochondrial fission | decreased growth rate | decreased phagocytosis | decreased vegetative cell size | increased slug migration | increased glutamate level | decreased phototaxis
DG1020migA-migAabolished slug migration | decreased mound size | aberrant fruiting body morphogenesis | decreased fruiting body size
DBS0350025mip1-mip1-1increased mound size | decreased chemotaxis to cAMP
DBS0350025mip1-mip1-2increased mound size | decreased chemotaxis to cAMP
DBS0236561mkcA-/ tagB-mkcAdecreased sporulation
DBS0236561mkcA-/ tagB-tagBdecreased sporulation
DBS0236562mkcA-/ tagC-mkcAdecreased sporulation
DBS0236562mkcA-/ tagC-tagCdecreased sporulation
DG1101mkcB-mkcBdecreased fruiting body size
DBS0236564mkkA-mkkAprecocious culmination | decreased sorus size | increased stalk length
DG1121mkpA-mkpAabolished aggregation
DBS0236566mlcE-mlcEaberrant cytokinesis | decreased growth rate | delayed aggregation | aberrant taxis | aberrant sorocarp development | decreased cell motility | aberrant gene expression
DBS0236567mlcR-mlcRaberrant cytokinesis | development arrests at mound stage | aberrant myosin II filament organization
DBS0351550mlcR-/ [ecmAO]: GFPmlcRaberrant development of tipped mound
DBS0349919mlkA-/ [act15]: GFP-mhcAmlkAaberrant stalk morphogenesis
DG1033modA-modAdecreased response to Gram-negative bacterium | abolished catalytic activity | aberrant fruiting body morphogenesis
DBS0266903mpl1-mpl1abolished stream development | decreased cell motility | decreased chemotaxis to cAMP | abolished aggregation
DBS0349986mrfA-mrfAaberrant slug migration | delayed development
DBS0350390mrfA-/ [act15]: myc: mrfA(S767A): FLAGmrfAaberrant protein modification | delayed development
DBS0349987mrfA-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZdimBdecreased prestalk A cell differentiation
DBS0349988mrfA-/ dimB-/ [emcA]: lacZmrfAdecreased prestalk A cell differentiation
DBS0236569mrps4-mrps4delayed aggregation | aberrant fruiting body morphogenesis
DBS0304881mrps4-mrps4delayed aggregation
DBS0304882mtDNA-DidioMp05abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp21abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp26abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp27abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp30abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp35abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-DidioMp36abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-ai2aabolished vegetative growth | abolished aggregation
DBS0304882mtDNA-ai2babolished vegetative growth | abolished aggregation
DBS0304882mtDNA-ai3abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-ai4abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-atp1abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-atp4abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-atp6abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-atp8abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-atp9abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-cox1/ 2abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-cox3abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-cytBabolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrpl11abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrpl14abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrpl16abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrpl2abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrpl6abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps12abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps13abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps14abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps19abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps2abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps4abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps7abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-mrps8abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad1abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad11abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad2abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad3abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad4abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad4Labolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad5abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad6abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad7abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-nad9abolished vegetative growth | abolished aggregation
DBS0304882mtDNA-rnlAabolished vegetative growth | abolished aggregation
DBS0350868mtpn-mtpndecreased actin filament polymerization | decreased growth rate | decreased cell motility | aberrant stream morphology | decreased macropinocytosis
DBS0236570mybB-mybBdecreased gene expression | decreased activation of adenylate cyclase activity | decreased cGMP-mediated signaling | abolished aggregation
DBS0236571mybB-mybBabolished aggregation
HM388mybC-mybCdecreased gene expression | development arrests at slug stage | decreased prespore gene expression | abolished culmination
DBS0236572mybE-mybEincreased migratory slug size | increased gene expression | abolished outer basal disc formation
DBS0237709mybE-/ [mrrA]: lacZmrrAaberrant prestalk cell differentiation
DBS0237709mybE-/ [mrrA]: lacZmybEaberrant prestalk cell differentiation
DBS0236573mybE-/ mybE: GFPmybEwild type | aberrant prestalk cell differentiation
HDT1myoA-myoAaberrant aggregation | decreased lateral pseudopodium retraction | delayed aggregation | decreased cell motility | decreased chemotaxis rate | aberrant pseudopodium formation | decreased chemotaxis to cAMP
HDT2myoA-myoAincreased secretion of lysosomal enzymes | delayed aggregation
HDT5myoA-/ myoB-myoAdecreased pinocytosis | increased secretion of lysosomal enzymes | increased filopodium formation | aberrant aggregation | aberrant endosomal transport | decreased defense response to Gram-negative bacterium | aberrant cortical actin cytoskeleton organization | increased lateral pseudopodium formation | decreased growth rate | delayed aggregation | decreased cell motility | decreased fruiting body size | aberrant actin filament organization | decreased chemotaxis to cAMP | aberrant cytoskeleton organization
HDT5myoA-/ myoB-myoBdecreased pinocytosis | increased secretion of lysosomal enzymes | increased filopodium formation | aberrant aggregation | aberrant endosomal transport | decreased defense response to Gram-negative bacterium | aberrant cortical actin cytoskeleton organization | increased lateral pseudopodium formation | decreased growth rate | delayed aggregation | decreased cell motility | decreased fruiting body size | aberrant actin filament organization | decreased chemotaxis to cAMP | aberrant cytoskeleton organization
DBS0350990myoA-/ myoB-/ [act15]: myoBmyoAdelayed aggregation
DBS0350990myoA-/ myoB-/ [act15]: myoBmyoBdelayed aggregation
DBS0351038myoA-/ myoF-myoAdecreased lateral pseudopodium retraction | decreased cell motility | decreased chemotaxis to cAMP | aberrant cell morphology | abolished aggregation
DBS0351038myoA-/ myoF-myoFdecreased lateral pseudopodium retraction | decreased cell motility | decreased chemotaxis to cAMP | aberrant cell morphology | abolished aggregation
DBS0236579myoB-myoBincreased secretion of lysosomal enzymes | aberrant aggregation | decreased lateral pseudopodium retraction | decreased cell motility | decreased chemotaxis to cAMP
DBS0236580myoB-myoBincreased lateral pseudopodium formation | decreased phagocytosis | delayed aggregation | decreased cell motility
DBS0236583myoB-/ [AS]myoDmyoBdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased mound size | decreased cell motility
DBS0236583myoB-/ [AS]myoDmyoDdecreased pinocytosis | aberrant aggregation | decreased growth rate | decreased phagocytosis | decreased mound size | decreased cell motility
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoBdecreased pinocytosis | aberrant aggregation | decreased pinosome size | decreased growth rate | decreased phagocytosis | decreased mound size | decreased cell motility | increased number of pinosomes
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoCdecreased pinocytosis | aberrant aggregation | decreased pinosome size | decreased growth rate | decreased phagocytosis | decreased mound size | decreased cell motility | increased number of pinosomes
DBS0236584myoB-/ [AS]myoD/ [KD]myoCmyoDdecreased pinocytosis | aberrant aggregation | decreased pinosome size | decreased growth rate | decreased phagocytosis | decreased mound size | decreased cell motility | increased number of pinosomes
HDT6myoB-/ myoC-myoBincreased secretion of lysosomal enzymes | decreased pinocytosis | increased filopodium formation | decreased growth rate | decreased cell motility | decreased fruiting body size | aberrant actin filament organization | aberrant cytoskeleton organization
HDT6myoB-/ myoC-myoCincreased secretion of lysosomal enzymes | decreased pinocytosis | increased filopodium formation | decreased growth rate | decreased cell motility | decreased fruiting body size | aberrant actin filament organization | aberrant cytoskeleton organization
DBS0351031myoD-/ myoE-myoDdecreased fruiting body size
DBS0351031myoD-/ myoE-myoEdecreased fruiting body size
DBS0351034myoD-/ myoE-/ myoF-myoDdecreased actin filament polymerization | aberrant engulfment during phagocytosis | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0351034myoD-/ myoE-/ myoF-myoEdecreased actin filament polymerization | aberrant engulfment during phagocytosis | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0351034myoD-/ myoE-/ myoF-myoFdecreased actin filament polymerization | aberrant engulfment during phagocytosis | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0351033myoD-/ myoF-myoDdecreased fruiting body size
DBS0351033myoD-/ myoF-myoFdecreased fruiting body size
DBS0351032myoE-/ myoF-myoEdecreased fruiting body size
DBS0351032myoE-/ myoF-myoFdecreased fruiting body size
HDT8myoF-myoFaberrant aggregation | wild type | increased lateral pseudopodium formation | decreased cell motility | decreased chemotaxis to cAMP | aberrant cell morphology
DBS0350251myoG-myoGdecreased protein localization to plasma membrane | decreased actin filament polymerization | abolished establishment of cell polarity | aberrant chemotaxis to cAMP | abolished aggregation
DBS0236589myoI-myoIdecreased spore germination
DBS0349844myoK-myoKaberrant cortical actin cytoskeleton organization | delayed aggregation | decreased phagocytosis | aberrant engulfment during phagocytosis | aberrant phagosome maturation | decreased chemotaxis rate | aberrant cell morphology | delayed phagosome acidification
DBS0351046nad2-nad2decreased defense response to Gram-negative bacterium | decreased gene expression | decreased growth rate | aberrant fruiting body morphogenesis | aberrant phototaxis
HC476ncsA-ncsAincreased cAMP level | precocious gene expression | precocious development
HC477ncsA-ncsAincreased cAMP level | precocious gene expression | precocious development
DBS0350297ncstn-ncstnaberrant culmination | abolished catalytic activity | decreased prespore cell differentiation
DBS0350301ncstn-/ psenA-ncstnaberrant culmination | decreased prespore cell differentiation
DBS0350301ncstn-/ psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0349947ndm-ndmaberrant chemotaxis | increased pinocytosis | decreased fruiting body size | aberrant pseudopodium formation
DBS0350121ndufaf5-ndufaf5aberrant spore morphology | decreased growth rate | delayed development | aberrant phototaxis | decreased fruiting body size | decreased sporulation
DBS0304633nfaA-nfaAaberrant extracellular cAMP signaling pathway | aberrant activation of GTPase activity | increased actin filament polymerization | delayed aggregation | decreased cell motility | aberrant regulation of GTPase activity | aberrant regulation of protein kinase activity | aberrant protein localization to plasma membrane | decreased chemotaxis to cAMP | increased pseudopodium formation
DBS0351061ngap-ngapaberrant regulation of fruiting body formation | aberrant extracellular cAMP signaling pathway | aberrant adaptation of signaling pathway | increased actin filament polymerization | aberrant chemotaxis to cAMP | aberrant regulation of protein kinase activity | decreased establishment of cell polarity | increased activation of GTPase activity
DBS0236604nhe1-nhe1abolished cell motility in response to calcium ion | decreased intracellular pH | abolished establishment of cell polarity | decreased actin filament polymerization | decreased chemotaxis rate | delayed development | aberrant actin filament organization | decreased establishment of cell polarity | abolished chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)aip1abolished aggregation | abolished chemotaxis to cAMP
DBS0350006nhe1-/ [act15]: GFP: aip1(E125A, E167A, F181A, F193A)nhe1abolished aggregation | abolished chemotaxis to cAMP
DBS0350001nhe1-/ [act15]: aip1(168-597)aip1delayed development
DBS0350001nhe1-/ [act15]: aip1(168-597)nhe1delayed development
DBS0236606nosA null (15-S-12)nosAdevelopment arrests at mound stage
DBS0236607nosA null (2E4)nosAdevelopment arrests at mound stage
DBS0235950nosA-nosAdevelopment arrests at mound stage | aberrant protein modification
DBS0236608noxA-noxAabolished sporulation | aberrant sorocarp development
DBS0236611noxA-/ [act15]: noxA: myc2noxAaberrant fruiting body morphogenesis
DBS0236610noxA-/ noxBnoxAabolished sporulation | aberrant sorocarp development | decreased superoxide generation
DBS0236610noxA-/ noxBnoxBabolished sporulation | aberrant sorocarp development | decreased superoxide generation
DBS0236612noxB-noxBabolished sporulation | aberrant sorocarp development | decreased superoxide generation
DBS0236613noxC-noxCabolished sporulation | aberrant sorocarp development
DBS0350092nrampB-nrampBdecreased defense response to Gram-negative bacterium | delayed aggregation
DBS0350093nrampB-/ nramp1-nramp1increased number of tip-organizers | decreased defense response to Gram-negative bacterium | delayed aggregation
DBS0350093nrampB-/ nramp1-nrampBincreased number of tip-organizers | decreased defense response to Gram-negative bacterium | delayed aggregation
DBS0236955nxnA-nxnAdecreased lysosomal protein degradation | decreased culmination | decreased growth rate | delayed development | decreased chemotaxis to cAMP
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnAdevelopment arrests at mound stage
DBS0236702nxnA-/ [act15]: GFP: nxnB nxnBdevelopment arrests at mound stage
DBS0236704osbA-osbAincreased slug migration | precocious development
DBS0304465padA(1-276)padAaberrant aggregation | decreased cell-cell adhesion | decreased gene expression | development arrests at slug stage | delayed aggregation | aberrant stalk cell differentiation | aberrant chemotaxis to cAMP | aberrant stream morphology | aberrant fruiting body morphogenesis | delayed development
DBS0236705pakA-pakAaberrant cytokinesis | delayed development | decreased myosin II assembly
DBS0349885pakA-pakAdelayed development | decreased chemotaxis to cAMP | increased bleb assembly
DBS0350428pakB-/ [act15]: RFP: abpEabpE-1decreased chemotaxis to cAMP | aberrant establishment or maintenance of cell polarity | abolished aggregation | abolished protein localization to leading edge
DBS0350428pakB-/ [act15]: RFP: abpEabpE-2decreased chemotaxis to cAMP | aberrant establishment or maintenance of cell polarity | abolished aggregation | abolished protein localization to leading edge
DBS0350428pakB-/ [act15]: RFP: abpEpakBdecreased chemotaxis to cAMP | aberrant establishment or maintenance of cell polarity | abolished aggregation | abolished protein localization to leading edge
DBS0350281pakD-pakDaberrant cellular homeostasis | aberrant filopodium formation | aberrant actin cytoskeleton organization | abolished negative regulation of vegetative growth | abolished aggregation | aberrant actin filament polymerization | aberrant establishment or maintenance of cell polarity | decreased chemotaxis to cAMP | increased growth rate | aberrant cellular response to extracellular stimulus | abolished positive regulation of chemorepellant activity
DBS0350282pakD-/ [act15]: pakDpakDdevelopment arrests at mound stage
LAS45pats1-pats1decreased socially cooperative development
DBS0236728paxB-paxBdecreased exocytosis | decreased cell-substrate adhesion | abolished slug migration | increased chemotaxis to cAMP | development arrests at mound stage | decreased prespore gene expression | aberrant fruiting body morphogenesis | decreased cell migration to prestalk region | increased phagocytosis
DBS0236730paxB-/ [ecmA]: paxB: GFPpaxBdecreased cell migration to prestalk region
DBS0236732paxB-/ [pspA]: paxB: GFPpaxBdecreased cell migration to prestalk region
DBS0236734pde4-pde4decreased culmination | abolished stream development | delayed slug development | increased number of early culminant tips | increased protein level | delayed culmination
DBS0350517pdeD-pdeDdecreased 3',5'-cyclic-GMP phosphodiesterase activity | increased fruiting body size | aberrant stream morphology
DBS0350893pdeD-/ pdeE-/ [unk]: pdeEpdeDdelayed aggregation
DBS0350893pdeD-/ pdeE-/ [unk]: pdeEpdeEdelayed aggregation
DBS0236740pdiA-pdiAdecreased mound size | aberrant oscillatory cAMP signaling | decreased fruiting body size
DBS0350817pdkA-pdkAdecreased mound size | decreased protein kinase activation
DBS0350799pdkA-/ pdkB-pdkAaberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation | decreased establishment of cell polarity
DBS0350799pdkA-/ pdkB-pdkBaberrant chemotaxis to cAMP | development arrests at mound stage | decreased protein kinase activation | decreased establishment of cell polarity
DBS0350818pdkB-pdkBdecreased mound size
DBS0237029pdsA-pdsAaberrant chemotaxis to cAMP | aberrant stream morphology
UK7pdsA-pdsAdecreased 3',5'-cyclic-AMP phosphodiesterase activity | decreased gene expression | aberrant sorocarp development | abolished aggregation
HPX235pdsA-pdsAabolished catalytic activity | abolished aggregation
DBS0236749pefB-/ noxC-noxCabolished sporulation | aberrant sorocarp development
DBS0236749pefB-/ noxC-pefBabolished sporulation | aberrant sorocarp development
DBS0305022pgtB-pgtBaberrant cellular metabolic process | aberrant spore coat morphology | aberrant hyperosmotic response
DBS0305024pgtB-/ pgtC-pgtBaberrant cellular metabolic process | aberrant spore coat morphology | aberrant hyperosmotic response
DBS0305024pgtB-/ pgtC-pgtCaberrant cellular metabolic process | aberrant spore coat morphology | aberrant hyperosmotic response
DBS0236752phdA-phdAdecreased actin filament polymerization | decreased mound size | decreased chemotaxis rate | decreased fruiting body size
DBS0236755phg1A-phg1Aincreased secretion of lysosomal enzymes | decreased lysosomal protein degradation | decreased protein level | decreased cell-substrate adhesion | decreased gene expression | aberrant defense response to bacterium | aberrant cytokinesis | decreased phagocytosis | abolished defense response to bacterium | decreased growth rate | development arrests at slug stage | decreased protein localization to cell surface | aberrant phagocytosis | increased lysosomal pH | decreased protein stabilization
DBS0304872phg1A-/ phg1B-phg1Aincreased secretion of lysosomal enzymes | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0304872phg1A-/ phg1B-phg1Bincreased secretion of lysosomal enzymes | decreased cell-substrate adhesion | decreased phagocytosis | decreased growth rate | development arrests at tipped mound stage | abolished culmination
DBS0304866phg1B-phg1Bincreased secretion of lysosomal enzymes | decreased protein level | decreased phagocytosis | decreased growth rate | abolished culmination
DBS0236758phg2-phg2decreased cell-substrate adhesion | decreased phagocytosis | aberrant cytokinesis | decreased cell motility | aberrant cell morphology | aberrant actin filament organization | precocious development | precocious gene expression | aberrant response to nutrient
DBS0236762phlp1-phlp1decreased response to cAMP | aberrant regulation of protein modification | abolished chemotaxis to folate | decreased growth rate | abolished protein localization to plasma membrane | decreased cGMP-mediated signaling | abolished aggregation | abolished chemotaxis to cAMP
DBS0350824phr-phraberrant chemotaxis to cAMP | delayed development
HW288phyA-phyAabolished sporulation | abolished stalk development | abolished peptidyl-proline hydroxylation | abolished culmination | increased response to hypoxia
DBS0266770phyA-/ [ecmA]: phyA(R276A): mycphyAabolished peptidyl-proline hydroxylation | abolished culmination
piaA(G917D)piaA
DBS0236769piaA(G917D)/ [act15]: piaApiaAdelayed aggregation
DBS0351455piaA(G917D)/ [unk]: GFP: piaA(G963E)piaAabolished aggregation
DBS0236771piaA-piaAabolished aggregation | decreased myosin II assembly | increased phagocytosis
DBS0236779pik6-pik6decreased gene expression | abolished aggregation
DBS0236773pikA-/ pikB-pikAabolished stream development | decreased pinocytosis | aberrant aggregation | decreased exocytosis | aberrant activation of adenylate cyclase activity | aberrant macropinocytosis | abolished protein localization to plasma membrane | delayed aggregation | decreased spore cell differentiation | increased cAMP level | abolished vegetative growth | aberrant sorocarp development | aberrant phagolysosome formation | aberrant phagosome maturation | decreased phosphatidylinositol biosynthesis | aberrant fruiting body morphogenesis | aberrant actin filament organization | aberrant cell morphology
DBS0236773pikA-/ pikB-pikBabolished stream development | decreased pinocytosis | aberrant aggregation | decreased exocytosis | aberrant activation of adenylate cyclase activity | aberrant macropinocytosis | abolished protein localization to plasma membrane | delayed aggregation | decreased spore cell differentiation | increased cAMP level | abolished vegetative growth | aberrant sorocarp development | aberrant phagolysosome formation | aberrant phagosome maturation | decreased phosphatidylinositol biosynthesis | aberrant fruiting body morphogenesis | aberrant actin filament organization | aberrant cell morphology
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikAaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | aberrant macropinocytosis | decreased growth rate | decreased phagocytosis | decreased cell motility | increased bleb assembly | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikBaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | aberrant macropinocytosis | decreased growth rate | decreased phagocytosis | decreased cell motility | increased bleb assembly | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikCaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | aberrant macropinocytosis | decreased growth rate | decreased phagocytosis | decreased cell motility | increased bleb assembly | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikFaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | aberrant macropinocytosis | decreased growth rate | decreased phagocytosis | decreased cell motility | increased bleb assembly | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | aberrant signal transduction
HM1200pikA-/ pikB-/ pikC-/ pikF-/ pikG-pikGaberrant aggregation | decreased pinocytosis | decreased protein tyrosine phosphorylation | increased chemotaxis to folate | aberrant macropinocytosis | decreased growth rate | decreased phagocytosis | decreased cell motility | increased bleb assembly | decreased chemotaxis to cAMP | aberrant protein localization to plasma membrane | aberrant signal transduction
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikAaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikBaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikCaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikFaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-pikGaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
HM1295pikA-/ pikB-/ pikC-/ pikF-/ pikG-/ pten-ptenaberrant aggregation | decreased defense response to Gram-negative bacterium | decreased growth rate | decreased cell motility | increased resistance to N-Phenylthiourea
DBS0238073pikA-/ pikB-/ plaA-pikAdecreased actin filament polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0238073pikA-/ pikB-/ plaA-pikBdecreased actin filament polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0238073pikA-/ pikB-/ plaA-plaAdecreased actin filament polymerization | delayed aggregation | aberrant chemotaxis to cAMP | abolished positive chemotaxis
DBS0236777pikD1pikDabolished slug migration | delayed aggregation | decreased mound size | aberrant fruiting body morphogenesis | decreased sporulation
LAS31pikG-pikGaberrant socially cooperative development
DBS0350828pinA-/ [ecmAO]: lacZpinAaberrant prestalk cell differentiation
DBS0350827pinA-/ [pspA]: lacZpinAaberrant prespore cell differentiation
DBS0349901pisA-pisAincreased gene expression | precocious development | decreased fruiting body size | aberrant prestalk cell differentiation
DBS0236783pkaC-pkaCabolished gene expression | increased protein phosphorylation | aberrant response to abiotic stimulus | decreased protein level | decreased gene expression | decreased activation of GTPase activity | abolished catalytic activity | aberrant response to cAMP | increased cellular thermotolerance | aberrant myosin II filament organization | decreased protein kinase activation | abolished aggregation | aberrant actin filament organization | aberrant protein localization to plasma membrane | aberrant protein localization to cell cortex | abolished chemotaxis to cAMP | increased protein kinase activation | increased activation of GTPase activity | abolished positive regulation of chemorepellant activity
DBS0350694pkaC-/ [act15]: pkaCpkaCabolished culmination
DBS0350707pkaC-/ [act6]: pkaC(330-648)pkaCabolished aggregation
DBS0236782pkaC-/ gdt1-gdt1increased gene expression | abolished aggregation
DBS0236782pkaC-/ gdt1-pkaCincreased gene expression | abolished aggregation
HTY217pkaR(A31T)pkaRabolished protein kinase activation | precocious development
DBS0235411pkaR-pkaRabolished stream development | increased resistance to valproic acid | decreased spore germination | aberrant extracellular cAMP signaling pathway | aberrant response to lithium | increased gene expression | precocious sporulation | increased lateral pseudopodium formation | aberrant chemotaxis to cAMP | decreased cell motility | decreased fruiting body size | aberrant cell morphology
DBS0236785pkbA-/ pkgB-pkbAaberrant chemotaxis to cAMP | abolished vegetative growth | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | aberrant cellular response to extracellular stimulus | increased activation of GTPase activity | increased protein kinase activation
DBS0236785pkbA-/ pkgB-pkgBaberrant chemotaxis to cAMP | abolished vegetative growth | decreased chemotaxis rate | abolished protein phosphorylation | abolished aggregation | aberrant cellular response to extracellular stimulus | increased activation of GTPase activity | increased protein kinase activation
DBS0350916pkcA-pkcAdecreased cell-cell adhesion | decreased protein level | increased chemotaxis to cAMP | decreased gene expression | increased number of mound tips | increased actin filament polymerization | aberrant oscillatory cAMP signaling | decreased fruiting body size | abolished positive regulation of chemorepellant activity
DBS0350918pkcA-pkcAaberrant aggregation | decreased catalytic activity | aberrant cytokinesis | aberrant sorocarp development
DBS0350919pkcA-/ [act15]: pldBpkcAaberrant aggregation | decreased sporulation
DBS0350919pkcA-/ [act15]: pldBpldBaberrant aggregation | decreased sporulation
DBS0236786pkgB-pkgBdecreased protein phosphorylation | development arrests at mound stage | abolished spore cell differentiation
DBS0304638pkgB-pkgBdecreased cell-substrate adhesion | development arrests at mound stage | decreased chemotaxis rate | decreased taxis | increased cell motility | increased bleb assembly
DBS0236789pkgB-/ [act15]: pkgB(K182M)pkgBdevelopment arrests at mound stage
DBS0350319pks17-pks17decreased fatty acid level | increased gene expression | delayed development | decreased fruiting body size
LAS44pks2-pks2decreased socially cooperative development
LAS19pks26-pks26aberrant socially cooperative development
DBS0238068plaA-plaAaberrant chemotaxis to cAMP | abolished aggregation | abolished positive regulation of chemorepellant activity
DBS0238067plaA-plaAabolished aggregation
DBS0306196plaA-plaAaberrant chemotaxis to cAMP | decreased bleb assembly | decreased necrotic cell death
DG1067plbG-plbGdecreased stalk width | decreased stalk length
HAD236plc-plcdecreased protein localization to plasma membrane | aberrant chemotaxis to cAMP | decreased protein localization to cytoplasm | decreased protein kinase activation | abolished aggregation
HD10plc-plcaberrant cellular homeostasis | wild type | aberrant spore germination
DBS0236796pldB-pldBdecreased catalytic activity | precocious aggregation
DBS0236797pldB-/ [act15]: pldB: GFPpldBabolished aggregation
DBS0350604pldB-/ [unk]: GFPpldBincreased cell migration to prestalk region
DBS0350605pldB-/ [unk]: lacZpldBincreased cell migration to prestalk region
DBS0236799plip-plipdelayed aggregation
DBS0350007png-pngdelayed aggregation | decreased mound size | aberrant fruiting body morphogenesis
DBS0350492png-/ [ecmAO]: lacZpngaberrant prestalk cell differentiation
DBS0350491png-/ [ecmA]: lacZpngaberrant prestalk A cell differentiation
DBS0350493png-/ [pspA]: lacZpngdecreased prespore cell differentiation
DBS0236820ponA-ponAprecocious aggregation | decreased actin nucleation | aberrant sorocarp development | aberrant pseudopodium formation
DBS0236821ponA-ponAprecocious aggregation | decreased actin nucleation | aberrant sorocarp development | aberrant pseudopodium formation
DG1057potA-potAaberrant fruiting body morphogenesis
DBS0236824ppk1-ppk1decreased growth rate | decreased phagocytosis | decreased fruiting body size | delayed culmination | decreased sporulation
ASH01ppk1-ppk1aberrant cellular homeostasis | decreased ATP level | decreased growth rate | aberrant spore germination | aberrant macromolecule biosynthesis | decreased fruiting body size | increased growth rate
DBS0238099ppp4C-ppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAppp4cdevelopment arrests at mound stage | delayed development
DBS0238110ppp4C-/ [act15]: smkAsmkAdevelopment arrests at mound stage | delayed development
DBS0266803psenA-psenAaberrant culmination | decreased prespore cell differentiation
DBS0350302psenA-psenAdecreased prespore cell differentiation | aberrant calcium-mediated signaling
DBS0350304psenA-/ psenB-psenAincreased gene expression | abolished prespore cell differentiation | development arrests at mound stage | increased protein modification | decreased phagocytosis | aberrant calcium-mediated signaling | increased cAMP level | aberrant sorocarp development | decreased macropinocytosis | aberrant phagosome maturation | decreased protein processing in phagocytic vesicle | decreased prestalk gene expression | decreased stalk cell differentiation
DBS0350304psenA-/ psenB-psenBincreased gene expression | abolished prespore cell differentiation | development arrests at mound stage | increased protein modification | decreased phagocytosis | aberrant calcium-mediated signaling | increased cAMP level | aberrant sorocarp development | decreased macropinocytosis | aberrant phagosome maturation | decreased protein processing in phagocytic vesicle | decreased prestalk gene expression | decreased stalk cell differentiation
DBS0350303psenB-psenBdecreased prespore cell differentiation | aberrant calcium-mediated signaling
DBS0350298psenB-/ psenA-psenAaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
DBS0350298psenB-/ psenA-psenBaberrant culmination | decreased phagocytosis | abolished catalytic activity | decreased prespore cell differentiation
HOK2psiA-psiAabolished prespore cell division
DBS0236828pslA-pslAabolished sporulation | increased mound size | decreased sorus size | aberrant prestalk gene expression | increased stalk length | abolished stalk cell differentiation | abolished prespore gene expression
DBS0236829psmC1-psmC1increased resistance to spectinomycin | aberrant standing slug morphology | abolished slug migration | increased vegetative cell size
HW70pspB-pspBaberrant spore coat morphology | precocious spore germination
DBS0302352psrA-psrAdecreased culmination | increased protein phosphorylation | decreased activation of GTPase activity | delayed prestalk gene expression | decreased cell motility | delayed development | increased protein kinase activation
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)gskAdecreased culmination | decreased prespore gene expression | delayed development | increased protein kinase activation
DBS0302357psrA-/ [act15]: gskA(K84M/ K85M)psrAdecreased culmination | decreased prespore gene expression | delayed development | increased protein kinase activation
HM1289pten-ptenaberrant cell motility | decreased lateral pseudopodium retraction | decreased cell motility | decreased macropinocytosis | abolished aggregation | decreased chemotaxis to cAMP
DBS0236830pten-ptendecreased response to Gram-negative bacterium | decreased positive regulation of GTPase activity | decreased actin filament polymerization | decreased lateral pseudopodium retraction | abolished protein localization to plasma membrane | decreased growth rate | increased actin filament polymerization | decreased phagocytosis | decreased bleb assembly | decreased cell motility | increased protein localization to plasma membrane | decreased chemotaxis to cAMP | abolished aggregation | aberrant pseudopodium formation | increased pseudopodium formation | aberrant signal transduction | abolished positive regulation of chemorepellant activity
DBS0236832ptpA1-ptpA1-1decreased prespore cell differentiation | precocious development | increased prestalk O cell differentiation
DBS0236832ptpA1-ptpA1-2decreased prespore cell differentiation | precocious development | increased prestalk O cell differentiation
DBS0236833ptpB-ptpBincreased migratory slug size
DBS0350675ptpB-/ [act15]: 6xHis: erkAerkAaberrant stream morphology
DBS0350675ptpB-/ [act15]: 6xHis: erkAptpBaberrant stream morphology
DBS0236835pufA-pufAincreased protein kinase activity | aberrant fruiting body morphogenesis | increased protein level | precocious development
DBS0304391pyk3-pyk3increased prespore gene expression | decreased prestalk gene expression | increased prespore cell differentiation | delayed culmination
DBS0236836pykA-pykAdecreased growth rate | abolished aggregation
DBS0350017qdpr-qdprdecreased spore germination | decreased growth rate | abolished catalytic activity | aberrant response to oxidative stress
DBS0236839qkgA-qkgA-1increased mound size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0236839qkgA-qkgA-2increased mound size | delayed aggregation | aberrant vegetative growth | aberrant nucleus organization | increased growth rate | abolished negative chemotaxis
DBS0351552qkgA-qkgA-1aberrant aggregation | decreased actin filament polymerization | aberrant cytokinesis | decreased cell motility | decreased chemotaxis to cAMP
DBS0351552qkgA-qkgA-2aberrant aggregation | decreased actin filament polymerization | aberrant cytokinesis | decreased cell motility | decreased chemotaxis to cAMP
DBS0236841racB-racBdecreased actin filament polymerization | delayed aggregation | aberrant fruiting body morphogenesis | decreased chemotaxis rate | decreased myosin II assembly
DBS0236842racC-racCdecreased protein localization to plasma membrane | decreased actin filament polymerization | aberrant cytokinesis | aberrant stream morphology | decreased chemotaxis rate | aberrant cell morphology | aberrant protein localization
DBS0350271racE-racEdecreased protein phosphorylation | increased lateral pseudopodium formation | aberrant cytokinesis | delayed aggregation | decreased growth rate | aberrant regulation of GTPase activity | aberrant protein localization to plasma membrane | decreased establishment of cell polarity | decreased chemotaxis to cAMP
DBS0236845racF2(N17T)racF2increased cell-cell adhesion | decreased sexual fusion
DBS0236843racF2-racF2increased mound size | increased cell-cell adhesion | decreased sexual fusion
DBS0351149rapC-rapCincreased number of mound tips | aberrant cytokinesis | increased cell-substrate adhesion | decreased cell motility | aberrant cell morphology
DBS0350864rapgap3-/ AX2rapgap3delayed aggregation | decreased chemotaxis to cAMP | decreased fruiting body size
DBS0350863rapgap3-/ KAX3rapgap3delayed development of tipped mound | increased calcium-dependent cell-cell adhesion | decreased cell motility | aberrant cell migration to prestalk region | aberrant regulation of GTPase activity
DBS0350316rapgap9-rapgap9increased filopodium formation | increased actin filament polymerization | aberrant cytokinesis | decreased spore size | increased cell-substrate adhesion | decreased chemotaxis to cAMP
DBS0350628rapgapB-rapgapBaberrant aggregation | increased cell-substrate adhesion | aberrant regulation of GTPase activity | aberrant actin filament organization
DBS0350631rapgapB-/ [ecmA]: lacZrapgapBaberrant cell migration to prestalk region
DBS0350632rapgapB-/ [ecmO]: lacZrapgapBaberrant cell migration to prestalk region
DBS0236853rasC-/ AX2rasCincreased rate of endocytosis | aberrant response to cAMP | decreased cell motility | increased vegetative cell size | abolished protein kinase activation | decreased protein kinase activation | decreased taxis | abolished aggregation | aberrant pseudopodium formation | aberrant actin filament organization | aberrant protein localization to cell cortex | aberrant cellular response to extracellular stimulus
DBS0236854rasC-/ JH10rasCwild type | aberrant gene expression | decreased protein kinase activation | abolished aggregation | abolished chemotaxis to cAMP
DBS0350740rasC-/ [rasC]: rasGrasCabolished activation of adenylate cyclase activity | abolished aggregation
DBS0350740rasC-/ [rasC]: rasGrasGabolished activation of adenylate cyclase activity | abolished aggregation
DBS0350741rasC-/ [rasC]: rasG(D30A)rasCaberrant aggregation | decreased activation of adenylate cyclase activity
DBS0350741rasC-/ [rasC]: rasG(D30A)rasGaberrant aggregation | decreased activation of adenylate cyclase activity
DBS0236855rasC-/ dmpA-dmpAabolished stream development
DBS0236855rasC-/ dmpA-rasCabolished stream development
DBS0236856rasC-/ pikD1pikDincreased establishment of cell polarity | increased chemotaxis to cAMP | aberrant gene expression | aberrant fruiting body morphogenesis | decreased protein kinase activation | abolished aggregation
DBS0236856rasC-/ pikD1rasCincreased establishment of cell polarity | increased chemotaxis to cAMP | aberrant gene expression | aberrant fruiting body morphogenesis | decreased protein kinase activation | abolished aggregation
DBS0236857rasC-/ rasD-rasCabolished aggregation
DBS0236857rasC-/ rasD-rasDabolished aggregation
DBS0236858rasC-/ rasG-rasCaberrant cell separation during cytokinesis | wild type | aberrant cell motility | decreased activation of adenylate cyclase activity | decreased gene expression | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | abolished vegetative growth | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP | abolished positive regulation of chemorepellant activity
DBS0236858rasC-/ rasG-rasGaberrant cell separation during cytokinesis | wild type | aberrant cell motility | decreased activation of adenylate cyclase activity | decreased gene expression | abolished guanylyl cyclase activity | abolished chemotaxis to folate | decreased growth rate | aberrant chemotaxis to folate | abolished protein kinase activation | abolished vegetative growth | decreased cell motility | increased protein level | abolished aggregation | delayed gene expression | abolished chemotaxis to cAMP | abolished positive regulation of chemorepellant activity
DBS0351459rasD-/ AX3rasDincreased gene expression | increased prespore cell differentiation
DBS0236862rasG-/ AX2rasGdecreased pinocytosis | decreased gene expression | delayed aggregation | aberrant taxis | decreased cGMP-mediated signaling | decreased protein kinase activation | delayed gene expression
DBS0351460rasG-/ AX3rasGincreased prestalk cell differentiation
DBS0236863rasG-/ JH10rasGaberrant cell separation during cytokinesis | wild type | decreased gene expression | delayed aggregation | abolished activation of GTPase activity | aberrant chemotaxis to folate | decreased growth rate | decreased cGMP-mediated signaling | decreased protein kinase activation | delayed gene expression
DBS0350261rbg3-rbg3precocious development | increased growth rate
DBS0236877rblA-rblAincreased cell migration to prestalk region | decreased spore germination | decreased gene expression | increased gene expression | abolished negative regulation of vegetative growth | decreased growth rate | aberrant vegetative growth | decreased vegetative cell size | precocious development | increased prestalk cell differentiation
DBS0349999rblA-/ [act15]: GFPrblAincreased cell migration to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgbtgincreased cell migration to prestalk region
DBS0349996rblA-/ [act15]: GFP/ [act15]: myc: btgrblAincreased cell migration to prestalk region
DBS0236878rbrA-rbrAincreased gene expression | decreased gene expression | development arrests at slug stage | aberrant prespore gene expression | decreased cell migration to prestalk region | decreased phototaxis | decreased sporulation
DBS0305613rccA-rccAincreased resistance to cheating during development
DBS0236880rckA-rckAincreased mound size | precocious aggregation | delayed slug development | delayed prestalk gene expression | delayed prespore gene expression | increased chemotaxis rate
DBS0236885rckA-/ [act15]: myc: rckArckAdelayed development | decreased chemotaxis rate
DBS0236881rckA-/ [act15]: myc: rckA(C551A)rckAdelayed slug development | decreased chemotaxis rate
DBS0236883rckA-/ [act15]: myc: rckA(E510G/ N511A)rckAdelayed slug development | decreased chemotaxis rate
DBS0236884rckA-/ [act15]: myc: rckA(K867A)rckAdevelopment arrests at mound stage | decreased chemotaxis rate
FR17rdeA-rdeAprecocious aggregation | decreased mound size | aberrant fruiting body morphogenesis | precocious development | precocious gene expression
FR17rdeA-rdeAprecocious aggregation | decreased mound size | aberrant fruiting body morphogenesis | precocious development | precocious gene expression
DBS0350688rdeA-/ acaA-acaAincreased cAMP level | decreased sporulation
DBS0350688rdeA-/ acaA-rdeAincreased cAMP level | decreased sporulation
DBS0266664redA-redAdevelopment arrests at mound stage | aberrant mound color
DG1047redA-redAdevelopment arrests at mound stage | aberrant mound color
DBS0236889regA-regAincreased resistance to cisplatin | aberrant chemotaxis to cAMP | increased cAMP level | aberrant fruiting body morphogenesis
DBS0236958regA-regAdecreased spore germination | precocious sporulation | abolished protein localization to cell cortex | increased lateral pseudopodium formation | aberrant chemotaxis to cAMP
HR45regA-regAaberrant fruiting body morphogenesis
DBS0350372regA-/ KAX3regAprecocious sporulation | increased sporulation
DBS0235706regA-/ [act15]: dhkK(D1125N)dhkKaberrant fruiting body morphogenesis | precocious development
DBS0235706regA-/ [act15]: dhkK(D1125N)regAaberrant fruiting body morphogenesis | precocious development
DBS0235708regA-/ [act15]: dhkK(H825Q)dhkKaberrant fruiting body morphogenesis | precocious development
DBS0235708regA-/ [act15]: dhkK(H825Q)regAaberrant fruiting body morphogenesis | precocious development
DBS0351475regA-/ [act15]: erkAerkAdelayed slug development
DBS0351475regA-/ [act15]: erkAregAdelayed slug development
DBS0351472regA-/ [act15]: regA(R588A,R589A,L594A,I595A,L596A)regAdelayed development
DBS0351284regA-/ [act15]: regA(S142A)regAaberrant fruiting body morphogenesis | precocious development
DBS0351283regA-/ [act15]: regA(S142E)regAdelayed development
DBS0351285regA-/ [act15]: regA(S413A)regAincreased mound size | delayed development
DBS0351286regA-/ [act15]: regA(S413E)regAincreased mound size | delayed development
DBS0351287regA-/ [act15]: regA(T676A)regAdelayed sporulation
DBS0351288regA-/ [act15]: regA(T676E)regAaberrant fruiting body morphogenesis | precocious development
DBS0350670regA-/ [regA]: regA(D212N)regAprecocious sporulation
DBS0350380regA-/ dhkD-dhkDaberrant fruiting body morphogenesis
DBS0350380regA-/ dhkD-regAaberrant fruiting body morphogenesis
DBS0351473regA-/ regA(R588A,R589A,L594A,I595A,L596)regAprecocious sporulation | decreased mound size | increased protein binding | aberrant fruiting body morphogenesis
DBS0236891regA-/ tagB-regAdecreased sporulation
DBS0236891regA-/ tagB-tagBdecreased sporulation
DBS0236892regA-/ tagC-regAdecreased sporulation
DBS0236892regA-/ tagC-tagCdecreased sporulation
DBS0236893rgaA-rgaAabolished cell migration to prestalk region | aberrant cytokinesis | abolished stalk cell differentiation | decreased protein kinase activation | abolished culmination | decreased sporulation
DBS0349935rgaA-rgaAaberrant stalk morphogenesis | increased number of tip-organizers | aberrant cellular response to fluid shear stress | increased actin filament polymerization | increased growth rate | increased cell motility | aberrant actin filament organization
DBS0349921rgaA-/ [act15]: GFP-mhcArgaAaberrant stalk morphogenesis | aberrant development of tipped mound | abolished protein localization to apical plasma membrane
DBS0350020rgfA-/ [act15]: rgfArgfAdecreased chemotaxis to folate | delayed development
DBS0350192ric8-ric8abolished gene expression | abolished chemotaxis to folate | decreased chemotaxis to cAMP | abolished aggregation | aberrant signal transduction
DBS0236900ripA-ripAdecreased guanylyl cyclase activity | abolished activation of adenylate cyclase activity | decreased chemotaxis rate | decreased taxis | abolished aggregation | decreased establishment of cell polarity | aberrant regulation of protein kinase activity | decreased myosin II assembly | increased phagocytosis
DBS0351068rnf113-rnf113delayed aggregation | increased cell-substrate adhesion | decreased cell motility
DBS0350096roco11-roco11increased stalk length
DBS0350095roco4-roco4delayed slug development | aberrant stalk development | delayed culmination
DBS0238225rpkA-rpkAdevelopment arrests at loose mound stage | decreased defense response to Gram-negative bacterium | aberrant cellular response to nitrogen starvation | decreased phagocytosis | decreased cell motility | decreased establishment of cell polarity | abolished aggregation | aberrant cellular response to extracellular stimulus
DBS0236875rtoA-rtoAdecreased rate of endocytosis | increased defense response to Gram-negative bacterium | increased prestalk cell differentiation | delayed culmination
DBS0236911rtoA-rtoAdelayed development
DBS0236914rzpA-rzpAaberrant aggregation | decreased slug migration | increased mound size | increased prespore gene expression | decreased prestalk gene expression | delayed development
DBS0351564sbdS(1-30,TS18,31-274)sbdsdevelopment arrests at loose mound stage | aberrant cellular process | abolished vegetative growth
DG1105scaA-scaAabolished aggregation
DBS0350825scaA-scaAdecreased actin filament polymerization | aberrant chemotaxis to cAMP | abolished activation of GTPase activity | decreased protein kinase activation | abolished aggregation
DBS0236924scrA-scrAincreased number of tip-organizers | abolished protein localization to endolysosome | decreased exocytosis | decreased pinocytosis | decreased actin filament polymerization | increased lateral pseudopodium formation | decreased phagocytosis | decreased vegetative cell size | decreased fruiting body size | precocious development
DBS0350264sepA-sepAaberrant cytokinesis | delayed aggregation | decreased growth rate | decreased fruiting body size
DBS0351252sesn-sesnincreased mound size | aberrant standing slug morphology | decreased gene expression | decreased autophagy | aberrant response to oxidative stress
DBS0236928set1-set1precocious aggregation | abolished histone H3-K4 methylation | precocious gene expression
DG1008sfbA-sfbAdecreased fruiting body size
DBS0350889sgcA-/ AX2sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
DBS0350888sgcA-/ AX3sgcAaberrant aggregation | decreased guanylyl cyclase activity | aberrant chemotaxis to cAMP
SA555sglA-sglAincreased stalk width | increased resistance to cisplatin | increased mound size | decreased lateral pseudopodium retraction | decreased gene expression | abolished slug migration | decreased cell motility | decreased chemotaxis rate | decreased fruiting body size | aberrant cytoskeleton organization | decreased sporulation | increased resistance to carboplatin
SA554sglA-sglAdelayed aggregation | decreased mound size
DBS0236934shkA-shkAaberrant aggregation | decreased phagocytosis | aberrant cytokinesis | decreased chemotaxis rate | decreased fruiting body size | decreased establishment of cell polarity | aberrant actin filament organization
DBS0351170sir2A-sir2Aabolished slug migration | increased number of mound tips | increased gene expression | decreased gene expression | decreased growth rate | aberrant sorocarp development | decreased autophagy | decreased chemotaxis to cAMP | decreased cAMP level
DBS0350859sir2D-sir2Ddecreased gene expression | increased gene expression | increased number of mound tips | delayed aggregation | decreased growth rate | decreased autophagy | decreased mound size | decreased stalk length
DBS0350860sir2D-/ [ecmAO]: lacZsir2Ddecreased prestalk cell differentiation
DBS0350861sir2D-/ [pspA]: lacZsir2Daberrant prespore cell differentiation
DBS0236938smkA-smkAaberrant cytokinesis | delayed development | decreased chemotaxis rate | decreased myosin II assembly
HDB7YAsmlA-smlAincreased oscillatory cAMP signaling | decreased cell-cell adhesion | aberrant cellular metabolic process | decreased response to Gram-negative bacterium | increased resistance to cisplatin | decreased protein level | decreased guanylyl cyclase activity | increased myosin II assembly | increased actin filament polymerization | decreased cGMP-mediated signaling | decreased mound size | increased protein level | decreased secretion of lysosomal enzymes | increased cell motility | decreased fruiting body size
DBS0302657smlA-/ cnrN-cnrNdecreased fruiting body size
DBS0302657smlA-/ cnrN-smlAdecreased fruiting body size
DBS0304496smlA-/ sslA1(CR11)smlAincreased fruiting body size
DBS0304496smlA-/ sslA1(CR11)sslA1increased fruiting body size
DBS0350977snfA-snfAdecreased pinocytosis | increased cell death | decreased autophagic cell death | decreased phagocytosis | decreased number of autophagosomes | aberrant sorocarp development | decreased prespore cell differentiation | aberrant gene expression | aberrant protein modification | increased growth rate | aberrant prestalk cell differentiation | aberrant sporulation
DBS0302524sodC-sodCaberrant aggregation | decreased positive regulation of GTPase activity | decreased actin filament polymerization | increased actin filament polymerization | aberrant chemotaxis to cAMP | increased protein localization to plasma membrane | decreased chemotaxis rate | aberrant regulation of GTPase activity | aberrant protein localization to plasma membrane | aberrant cell morphology | increased protein kinase activation
DBS0350966spaA-spaAabolished sporulation
HL351spiA-spiAdecreased spore germination
DBS0236943spkA-1-/ spkA-2-spkA-1decreased cell-substrate adhesion | aberrant cytokinesis | decreased mound size | decreased chemotaxis rate | decreased establishment of cell polarity | aberrant cell morphology | decreased fruiting body size
DBS0236943spkA-1-/ spkA-2-spkA-2decreased cell-substrate adhesion | aberrant cytokinesis | decreased mound size | decreased chemotaxis rate | decreased establishment of cell polarity | aberrant cell morphology | decreased fruiting body size
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-1aberrant aggregation | decreased chemotaxis rate | aberrant actin filament organization | decreased establishment of cell polarity
DBS0236944spkA-1-/ spkA-2-/ [act15]: spkA: FLAGspkA-2aberrant aggregation | decreased chemotaxis rate | aberrant actin filament organization | decreased establishment of cell polarity
DBS0236945splA-splAabolished sporulation | aberrant spore morphology | increased sorus size | aberrant sorus color | decreased stalk length
DBS0236947spnA-spnAabolished prespore cell differentiation | development arrests at mound stage | abolished prestalk cell differentiation | aberrant sorocarp development
DBS0236948spnA-/ arkA-arkAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0236948spnA-/ arkA-spnAdecreased gene expression | increased sorus size | decreased stalk length | delayed gene expression
DBS0236949spr-sprdecreased spore germination | decreased pteridine level | decreased cytochrome C oxidase activity | decreased growth rate
DBS0350914spsA-spsAdecreased stalk length
DBS0236950srfA(1-8): lacZsrfAdecreased slug migration | aberrant fruiting body morphogenesis | delayed culmination
DBS0236951srfA-srfAaberrant spore morphology | decreased spore germination | aberrant spore coat morphology | decreased gene expression
DBS0266691srfB-srfBabolished stream development | aberrant extracellular cAMP signaling pathway | increased lateral pseudopodium formation | precocious aggregation | decreased growth rate | increased pinocytosis | aberrant cytokinesis | precocious gene expression
DBS0304409srsA-srsAincreased mound size | decreased gene expression | increased gene expression | delayed aggregation
DBS0304497sslA1-/ sslA1(CR11)sslA1increased fruiting body size | decreased oscillatory cAMP signaling | decreased cGMP-mediated signaling
DBS0236952stkA-stkAdecreased gene expression | increased prestalk gene expression | delayed prespore gene expression | aberrant fruiting body morphogenesis | increased prestalk cell differentiation
HM1157stlA-stlAaberrant aggregation | abolished sporulation | wild type | increased gene expression | decreased gene expression | aberrant stream morphology | decreased spore cell differentiation | decreased chemotaxis to cAMP | aberrant sorus color | abolished MPBD level | decreased cAMP level | aberrant sporulation
DBS0350222stlA-/ [cotB]: lacZstlAdecreased sporulation | aberrant prespore cell differentiation
DBS0350223stlA-/ stlB-stlAdecreased gene expression | increased gene expression | aberrant gene expression | decreased stalk width
DBS0350223stlA-/ stlB-stlBdecreased gene expression | increased gene expression | aberrant gene expression | decreased stalk width
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlAdecreased prestalk cell differentiation
DBS0350224stlA-/ stlB-/ [ecmA]: lacZstlBdecreased prestalk cell differentiation
HM1154stlB-stlBabolished DIF-1 biosynthesis | abolished prestalk B cell differentiation | aberrant gene expression | aberrant fruiting body morphogenesis | decreased prestalk O cell differentiation | abolished lower cup formation | abolished outer basal disc formation | decreased prestalk cell differentiation
DBS0351220stlB-stlBabolished autophagosome organization | abolished autophagic cell death
DBS0349941sunB-sunBincreased number of tip-organizers | aberrant cytokinesis
DBS0304547svkA-svkAdelayed cell separation during cytokinesis | aberrant cytokinesis | aberrant fruiting body morphogenesis
AK1200tagA-tagAdecreased spore cell differentiation | aberrant fruiting body morphogenesis
AK859tagA-tagAdecreased spore germination | increased number of mound tips | decreased spore cell differentiation | increased prestalk A cell differentiation | delayed culmination | decreased sporulation
AK1201tagA-/ [ecmA]: GFPtagAabolished cell migration to prestalk region
AK228tagB-tagBabolished sporulation | abolished DIF-1 biosynthesis | development arrests at mound stage | aberrant prestalk A cell differentiation
DBS0350637tagB-/ [pkaC]: pkaCpkaCaberrant response to biotic stimulus | abolished spore cell differentiation
DBS0350637tagB-/ [pkaC]: pkaCtagBaberrant response to biotic stimulus | abolished spore cell differentiation
DBS0350672tagB-/ pkaR-pkaRdecreased sporulation
DBS0350672tagB-/ pkaR-tagBdecreased sporulation
DBS0236974tagB-/ psmA1-psmA1abolished sporulation
DBS0236974tagB-/ psmA1-tagBabolished sporulation
DBS0236975tagC-tagCabolished sporulation | development arrests at mound stage
DBS0350698tagC-/ [pkaC]: pkaCpkaCdevelopment arrests at mound stage | abolished spore cell differentiation
DBS0350698tagC-/ [pkaC]: pkaCtagCdevelopment arrests at mound stage | abolished spore cell differentiation
DBS0304581talA-/ talB-talAdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility | increased bleb assembly
DBS0304581talA-/ talB-talBdevelopment arrests at loose mound stage | abolished cell-substrate adhesion | aberrant cytokinesis | abolished cell motility | increased bleb assembly
HKT104talB-talBdecreased slug migration | aberrant extracellular cAMP signaling pathway | aberrant cellular process | decreased cell motility | development arrests at tipped mound stage | increased protein level | aberrant signal transduction
DBS0302472talB-talBabolished autophagosome organization | abolished autophagic cell death | aberrant autophagic cell death
DBS0304586talB-/ [act15]: talA: GFPtalAaberrant fruiting body morphogenesis
DBS0304586talB-/ [act15]: talA: GFPtalBaberrant fruiting body morphogenesis
DBS0350712talB-/ [act15]: talB(K16A)talBdevelopment arrests at tipped mound stage
DBS0351346tert-tertincreased gene expression | decreased gene expression | aberrant cell adhesion | aberrant chemotaxis to cAMP | aberrant sorocarp development | delayed development | aberrant oscillatory cAMP signaling | decreased cAMP level
AK1505tgrB1-tgrB1development arrests at loose mound stage | delayed sporulation | decreased cell motility | decreased sporulation
DBS0351148tgrB1-/ tgrB1(1-827): HAtgrB1development arrests at mound stage
AK1540tgrB1-/ tgrC1-tgrB1development arrests at loose mound stage | abolished cell-cell self recognition | aberrant oscillatory cAMP signaling
AK1540tgrB1-/ tgrC1-tgrC1development arrests at loose mound stage | abolished cell-cell self recognition | aberrant oscillatory cAMP signaling
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)alg9decreased sporulation
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)tgrB1decreased sporulation
AK1664tgrB1-/ tgrC1-/ alg9(-19ins)tgrC1decreased sporulation
DBS0351133tgrB1-/ tgrC1-/ tgrB1(L846F)tgrB1aberrant standing slug morphology | increased number of mound tips | decreased fruiting body size
DBS0351133tgrB1-/ tgrC1-/ tgrB1(L846F)tgrC1aberrant standing slug morphology | increased number of mound tips | decreased fruiting body size
AK127tgrC1-tgrC1development arrests at loose mound stage | aberrant aggregation | abolished gene expression | increased mound size | decreased gene expression
AK1521tgrC1-tgrC1abolished sporulation | development arrests at loose mound stage | decreased cell motility
AK1657tgrC1-/ (QS38|tgrC1)/ alg9(-19ins)alg9delayed development | decreased fruiting body size | decreased sporulation
AK1657tgrC1-/ (QS38|tgrC1)/ alg9(-19ins)tgrC1delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)alg9delayed development | decreased fruiting body size | decreased sporulation
AK1661tgrC1-/ alg9(-19ins)tgrC1delayed development | decreased fruiting body size | decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMIalg9decreased sporulation
DBS0350743tgrC1-/ alg9(-19ins)-REMItgrC1decreased sporulation
DBS0350625tgrC1-/ stcA-stcAdecreased mound size | delayed development | decreased sporulation
DBS0350625tgrC1-/ stcA-tgrC1decreased mound size | delayed development | decreased sporulation
DBS0350626tgrC1-/ stcB-stcBdecreased mound size | delayed development | decreased sporulation
DBS0350626tgrC1-/ stcB-tgrC1decreased mound size | delayed development | decreased sporulation
DBS0350627tgrC1-/ stcC-stcCaberrant stream morphology | delayed development | decreased fruiting body size | decreased sporulation
DBS0350627tgrC1-/ stcC-tgrC1aberrant stream morphology | delayed development | decreased fruiting body size | decreased sporulation
AK244tipA-tipAincreased number of tip-organizers | increased mound size | development arrests at mound stage | decreased prestalk gene expression
JS64tipA-/ tipB-/ [act15]: lacZtipAincreased mound size | increased number of mound tips | development arrests at mound stage
JS64tipA-/ tipB-/ [act15]: lacZtipBincreased mound size | increased number of mound tips | development arrests at mound stage
JS98tipA-/ tipC-/ [ecmA]: lacZtipAdevelopment arrests at loose mound stage
JS98tipA-/ tipC-/ [ecmA]: lacZtipCdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipAdevelopment arrests at loose mound stage
JS128tipA-/ tipD-/ [ecmA]: lacZtipDdevelopment arrests at loose mound stage
DBS0351500tipB-tipBincreased number of mound tips
JS56tipB-tipBincreased number of tip-organizers | increased mound size | increased number of mound tips | development arrests at mound stage
JS99tipB-/ tipC-/ [ecmA]: lacZtipBincreased number of mound tips | development arrests at tipped mound stage
JS99tipB-/ tipC-/ [ecmA]: lacZtipCincreased number of mound tips | development arrests at tipped mound stage
JS129tipB-/ tipD-/ [ecmA]: lacZtipBincreased number of mound tips | development arrests at tipped mound stage
JS129tipB-/ tipD-/ [ecmA]: lacZtipDincreased number of mound tips | development arrests at tipped mound stage
JS55tipC-tipCincreased number of tip-organizers | increased mound size | development arrests at mound stage | decreased number of autophagosomes | decreased autophagy
DBS0350729tipC-/ [unk]: tipC(2725-3848): GFPtipCdecreased fruiting body size
JS130tipC-/ tipD-/ [ecmA]: lacZtipCdevelopment arrests at loose mound stage
JS130tipC-/ tipD-/ [ecmA]: lacZtipDdevelopment arrests at loose mound stage
JS93tipD-tipDincreased number of tip-organizers | increased mound size | development arrests at mound stage | aberrant vacuole organization | decreased autophagy
DBS0350730tipD-tipDdecreased pinocytosis | increased cell death | decreased spore germination | decreased catalytic activity | increased gene expression | increased number of mound tips | increased protein modification | aberrant phagosome maturation | aberrant slug development | aberrant fruiting body morphogenesis | abolished protein localization to autophagosome
DBS0236016tmcB-/ V12tmcBdecreased macrocyst size | aberrant macrocyst formation
DBS0236018tmcC-/ V12tmcCaberrant macrocyst formation
DBS0351084tnlA/ tnlB-REMItnlAdecreased gene expression | delayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0351084tnlA/ tnlB-REMItnlBdecreased gene expression | delayed aggregation | increased cell-substrate adhesion | decreased cell motility | increased protein kinase activation
DBS0237017torA-torAdelayed aggregation | decreased growth rate | decreased cell motility | decreased chemotaxis rate
DBS0351498tpc2-tpc2increased number of autophagosomes | increased gene expression | decreased gene expression | aberrant vegetative growth | aberrant calcium-mediated signaling | increased protein kinase activity | delayed development | increased lysosomal pH
DBS0350504tpp1-tpp1increased autophagic cell death | decreased catalytic activity | aberrant response to chemical | aberrant cell morphology | precocious development | decreased sporulation
DBS0351558tpt1-tpt1decreased spore germination | decreased gene expression | decreased growth rate | aberrant cytokinesis | decreased number of mounds | decreased macropinocytosis | delayed development | aberrant fruiting body morphogenesis | increased prestalk cell differentiation
DBS0351265trfA-trfAaberrant aggregation | aberrant vegetative growth | decreased chemotaxis to cAMP
DBS0237924triA-triAdecreased cell-cell adhesion | increased stalk width | increased number of mounds | decreased spore germination | aberrant upper cup formation | aberrant cell motility | aberrant stream morphology | decreased spore size | decreased cell fate determination | aberrant late culminant morphology
DBS0237996triA-triAaberrant late culminant morphology
DBS0237997triA-triAaberrant late culminant morphology
DBS0237998triA-/ [act15]: GFPtriAaberrant late culminant morphology
DBS0237999triA-/ [ecmAO]: lacZ: [ecmAO]: gustriAincreased prestalk O cell differentiation
DBS0238001triA-/ [psA]: lacZ: [psA]: gustriAincreased prespore cell differentiation
DBS0237022tsg101-tsg101decreased fruiting body size
DBS0302370tsuA-tsuAincreased oscillatory cAMP signaling | abolished establishment of cell polarity | aberrant chemotaxis to folate | aberrant chemotaxis to cAMP | delayed aggregation | decreased mound size | decreased fruiting body size | aberrant pseudopodium formation
DBS0302383tsuA-/ [unk]: tsuA(1-1774): YFPtsuAabolished protein localization to microtubules | abolished protein localization to microtubule organizing center | decreased mound size | decreased fruiting body size
DBS0302385tsuA-/ [unk]: tsuA(1-260): YFPtsuAabolished protein localization to microtubules | abolished protein localization to microtubule organizing center | decreased mound size | decreased fruiting body size
DBS0302384tsuA-/ [unk]: tsuA(1774-2247): YFPtsuAabolished protein localization to microtubules | abolished protein localization to microtubule organizing center | decreased mound size | decreased fruiting body size
DBS0302382tsuA-/ [unk]: tsuA(K34R): YFPtsuAdecreased mound size | decreased fruiting body size
DBS0237024ubcB-ubcBincreased number of tip-organizers | development arrests at mound stage
DBS0237025ubpA-ubpAdecreased gene expression | decreased chemotaxis rate | abolished aggregation
DBS0237026ubpB-ubpBaberrant sorus morphology | increased prestalk gene expression | decreased prespore gene expression | precocious development
DBS0351464uduB-/ AX3uduBincreased prestalk cell differentiation
DBS0237028ugpB-/ DH1ugpBabolished sporulation | decreased glycogen level | aberrant cell differentiation | decreased fruiting body size | delayed culmination
DBS0266763ugpB-/ DH1ugpBdecreased stalk length
DBS0351536vasP-/ hspc300-hspc300development arrests at slug stage | aberrant sorocarp development
DBS0351536vasP-/ hspc300-vasPdevelopment arrests at slug stage | aberrant sorocarp development
DBS0351537vasP-/ pirA-pirAincreased number of mound tips
DBS0351537vasP-/ pirA-vasPincreased number of mound tips
DBS0236058vmp1-vmp1aberrant aggregation | decreased exocytosis | increased cell death | aberrant autophagy | decreased gene expression | decreased growth rate | aberrant hypotonic response | decreased macropinocytosis | aberrant vacuole organization | aberrant protein localization to autophagosome | aberrant protein localization | aberrant signal transduction
DBS0351250vmp1-/ [act15]: vmp1(G268L): GFPvmp1aberrant aggregation | aberrant protein localization to autophagosome
DG1118vps46-vps46increased sorus size
DBS0237046vwkA-vwkAincreased myosin II assembly | decreased growth rate | aberrant cytokinesis | aberrant contractile vacuole morphology | aberrant hypotonic response | delayed development | increased protein level | aberrant fruiting body morphogenesis | decreased contractile vacuole discharge
DBS0237048warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0237049warA-warAdevelopment arrests at slug stage | increased basal disc size | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0237050warA-/ hbx2-hbx2increased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0237050warA-/ hbx2-warAincreased basal disc size | development arrests at mound stage | decreased prespore cell differentiation | increased prestalk O cell differentiation
DBS0237051wasA-wasAdecreased cell motility | delayed development | aberrant actin filament organization
DBS0237052wasA1-/ [tet]: YFP: wasA2wasAdecreased actin filament polymerization | abolished positive chemotaxis | abolished aggregation | aberrant actin filament organization
DG1053wimA-wimAaberrant fruiting body morphogenesis
DG1064wimA-wimAaberrant fruiting body morphogenesis
AK235yakA-yakAabolished aggregation
AK800yakA-yakAdecreased protein localization to cell cortex | decreased gene expression | aberrant cell cycle | increased cellular thermotolerance | aberrant gene expression | decreased protein kinase activation | abolished aggregation | aberrant response to oxidative stress | aberrant cellular response to stress | decreased cAMP level
DBS0237087yakA-/ AX3yakAdecreased growth rate | abolished aggregation | abolished actin filament polymerization | decreased cGMP biosynthesis
AK804yakA-/ pufA-pufAincreased protein kinase activity | increased protein level | aberrant fruiting body morphogenesis | increased growth rate | precocious development
AK804yakA-/ pufA-yakAincreased protein kinase activity | increased protein level | aberrant fruiting body morphogenesis | increased growth rate | precocious development
DBS0350898yelA-/ AX2yelAprecocious prestalk gene expression | increased basal disc size
DG1014yelA-/ AX4yelAaberrant spore morphology | precocious sporulation | development arrests at mound stage | aberrant mound color | aberrant sporulation
DBS0349797zak2-zak2decreased prespore gene expression | decreased protein kinase activation | aberrant fruiting body morphogenesis | decreased sporulation
DBS0349883zak2-/ [act15]: GFPzak2decreased sporulation
ARK100-110zakA-zakAabolished stream development | decreased protein kinase activity | increased prestalk gene expression | decreased prespore gene expression | aberrant fruiting body morphogenesis | decreased chemotaxis to cAMP | delayed culmination | decreased sporulation
DBS0238142zakA-zakAdevelopment arrests at tipped mound stage
DG1050zipA-zipAdecreased fruiting body size
DBS0350068zizB-zizBaberrant fruiting body morphogenesis | delayed development | decreased chemotaxis to cAMP

Last updated July 28, 2024

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